NCT06194799

Brief Summary

This 52-week, open-label extension study is to evaluate the long-term safety and tolerability of ACP-204 in subjects with ADP.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
752

participants targeted

Target at P75+ for phase_3

Timeline
36mo left

Started Apr 2024

Longer than P75 for phase_3

Geographic Reach
12 countries

69 active sites

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress41%
Apr 2024May 2029

First Submitted

Initial submission to the registry

December 22, 2023

Completed
17 days until next milestone

First Posted

Study publicly available on registry

January 8, 2024

Completed
4 months until next milestone

Study Start

First participant enrolled

April 23, 2024

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2029

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2029

Last Updated

May 4, 2026

Status Verified

December 1, 2025

Enrollment Period

4.9 years

First QC Date

December 22, 2023

Last Update Submit

May 1, 2026

Conditions

Keywords

Alzheimer's Disease PsychosisHallucinationsDelusions

Outcome Measures

Primary Outcomes (1)

  • Treatment-emergent adverse events

    Number of Subjects With Adverse Events (AEs), Discontinuations Due to AEs and Serious AEs (SAEs) over 52 weeks of treatment. The Safety population consists of all subjects who received at least one dose of study drug in this study.

    52 Weeks

Secondary Outcomes (1)

  • Clinical Global Impression-Improvement in the ADP context (CGI-I-ADP) score

    52 Weeks

Study Arms (1)

ACP-204

EXPERIMENTAL

ACP-204 30mg or 60mg

Drug: ACP-204

Interventions

ACP-204 30 mg given once daily, as capsule OR ACP-204 60 mg given once daily, as capsule

ACP-204

Eligibility Criteria

Age55 Years - 95 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Subject has successfully completed ACP-204-006 study
  • Male or female (age 55 to 95 years old): female must be of non-childbearing potential, male must take appropriate contraceptive method if partner has childbearing potential
  • Subject has a designated study partner/caregiver
  • Subjects are able to complete all study visits with a study partner/caregiver
  • Signed inform consent form with a caregiver or legal representative

You may not qualify if:

  • Requires treatment with a medication prohibited by the protocol
  • Is in hospice and receiving end-of-life palliative care, or has become bedridden
  • Unstable clinically significant medical condition other than AD
  • Any medical condition that in the opinion of the investigator may affect safety or ability to complete the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (69)

ATP Clinical Research

Costa Mesa, California, 92626, United States

Location

Neuro-Pain Medical Center

Fresno, California, 93710, United States

Location

New Life Medical Research Center

Hialeah, Florida, 33012, United States

Location

Reliable Clinical Research LLC

Hialeah, Florida, 33012, United States

Location

Homestead Associates in Research Inc.

Miami, Florida, 33032, United States

Location

Premier Clinical Research Institute Inc

Miami, Florida, 33122, United States

Location

Advanced Clinical Research

Miami, Florida, 33135, United States

Location

Verus Clinical Research

Miami, Florida, 33135, United States

Location

Quantum Clinical Trials

Miami, Florida, 33140, United States

Location

Future Care Solution, LLC

Miami, Florida, 33165, United States

Location

MediClear Medical & Research Center, Inc.

Miami, Florida, 33165, United States

Location

ABBA Medical Research LLC

Miami, Florida, 33176, United States

Location

New Med Research

Miami Gardens, Florida, 33056, United States

Location

Floridian Neuroscience Institute

Miami Lakes, Florida, 33016, United States

Location

Abington Neurological Associates

Abington, Pennsylvania, 19001, United States

Location

Horizon Clinical Research Group

Cypress, Texas, 77429, United States

Location

Uni Texas Health Science Center

Houston, Texas, 77054, United States

Location

Clinical Trial Network LLC

Houston, Texas, 77074, United States

Location

Kaleidoscope Clinical Research

Houston, Texas, 77089, United States

Location

Hospital Moinhos de Vento

Porto Alegre, Rio Grande do Sul, 90035-001, Brazil

Location

Hospital Universitario de Brasilia

Brasília, 70840-901, Brazil

Location

TrialTech Tecnologia com Pesquisas em Medicamentos

Curitiba, 80240-280, Brazil

Location

Inst de Neurologia de Curitiba Hospital Ecoville

Curitiba, 81210-310, Brazil

Location

Instituto Mederi de Pesquisa e Saude

Passo Fundo, 99010-120, Brazil

Location

Ruschel Medicina e Pesquisa Clínica

Rio de Janeiro, 22270-060, Brazil

Location

Facili - Centro Integrado de Psiquiatria

São Bernardo do Campo, 09726-150, Brazil

Location

BR Trials-Ensaios Clinicos e Consultoria

São Paulo, 01236-030, Brazil

Location

ET Dr. Ivo Natsov-AIPSMC in Psychiatry

Cherven Bryag, 5980, Bulgaria

Location

Medical Center Lifemed

Kardzhali, 6600, Bulgaria

Location

DCC Higia

Pazardzhik, 4402, Bulgaria

Location

Medical center Medconsult Pleven OOD

Pleven, 5800, Bulgaria

Location

Mental Health Centre-Prof. N Shipkovenski EOOD

Sofia, 1000, Bulgaria

Location

DCC St. Vrach and St. St. Kuzma and Damian OOD

Sofia, 1408, Bulgaria

Location

UMHAT Alexandrovska EAD

Sofia, 1431, Bulgaria

Location

Psicomed Estudios Medicos

Antofagasta, 1270244, Chile

Location

Biomedica Research Group

Santiago, 7500710, Chile

Location

Especialidades Medicas L y S

Santiago, 7560356, Chile

Location

CIC de la Universidad Catolica CICUC

Santiago, 8330024, Chile

Location

Fakultni nemocnice u sv. Anny v Brne

Brno, 656 91, Czechia

Location

BRAIN-SOULTHERAPY s.r.o

Kladno, 27201, Czechia

Location

AD71 s.r.o

Prague, 109 00, Czechia

Location

Clinical s.r.o

Prague, 110 00, Czechia

Location

Vestra Clinics s.r.o.

Rychnov nad Kněžnou, 516 01, Czechia

Location

Hôpital Lariboisière

Paris, 75010, France

Location

Hôpital La Grave

Toulouse, 31059, France

Location

ASST Spedali Civili di Brescia

Brescia, 25123, Italy

Location

Azienda Ospedaliera Universitaria OO. RR. S

Salerno, 84131, Italy

Location

Hospital Universitario Dr. Jose Eleuterio Gonzalez

Monterrey, Neuvo Leon, 64460, Mexico

Location

Iecsi S.C.

Monterrey, Nuevo León, 64310, Mexico

Location

Neurociencias Estudios Clinicos

Culiacán, Sinaloa, 80020, Mexico

Location

Centro para el Des de la Med y de Asist Med Esp SC

Culiacán, Sinaloa, 80230, Mexico

Location

Hospital Universitario de Saltillo

Coahuila, 25000, Mexico

Location

BIND Investigaciones S.C.

San Luis Potosí City, 78213, Mexico

Location

Clinical Center Dr Dragisa Misovic Dedinje

Belgrade, 11000, Serbia

Location

Institute of Mental Health

Belgrade, 11000, Serbia

Location

Special Hospital for Psychiatric Diseases

Gornja Toponica, 18202, Serbia

Location

Janjic University Clinical Center Kragujevas

Kragujevac, 34000, Serbia

Location

Jovanovic University Clinical Centre of Kragujevac

Kragujevac, 34000, Serbia

Location

Petrovic University Clinical Center Kragujevac

Kragujevac, 34000, Serbia

Location

University Clinical Center Nis

Niš, 18000, Serbia

Location

The Catholic University of Korea

Seoul, Republic of Korea, 03312, South Korea

Location

Inha University Hospital

Incheon, 22332, South Korea

Location

Samsung Medical Center

Seoul, 06351, South Korea

Location

Seoul National University Boramae Medical Center

Seoul, 07061, South Korea

Location

Hospital Universitario Virgen Macarena

Seville, 41009, Spain

Location

Hospital Provincial de Zamora

Zamora, 49021, Spain

Location

Kaohsiung Municipal Ta-Tung Hospital

Kaohsiung City, 80145, Taiwan

Location

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 80756, Taiwan

Location

E-DA Hospital

Kaohsiung City, 82445, Taiwan

Location

MeSH Terms

Conditions

HallucinationsDelusions

Condition Hierarchy (Ancestors)

Perceptual DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsBehavioral SymptomsBehavior

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 22, 2023

First Posted

January 8, 2024

Study Start

April 23, 2024

Primary Completion (Estimated)

April 1, 2029

Study Completion (Estimated)

May 1, 2029

Last Updated

May 4, 2026

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will not share

Locations