Comparison of Aqueous Humor Adipokines in Glaucoma Patients and Healthy Controls
Comparative Analysis of Aqueous Humor Adipokines in Patients With Glaucoma and Healthy Controls
1 other identifier
observational
2
1 country
1
Brief Summary
The purpose of this study is to observe whether there are differences in adipokines in the aqueous humor between patients with primary open-angle glaucoma (POAG) and healthy controls
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Oct 2023
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 8, 2023
CompletedFirst Submitted
Initial submission to the registry
December 19, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2023
CompletedFirst Posted
Study publicly available on registry
January 5, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2024
CompletedJanuary 5, 2024
December 1, 2023
3 months
December 19, 2023
December 19, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Concentration of adipokines in aqueous humor
Aqueous humor samples were assessed for adipokines and inflammatory cytokines by Luminex bead-based multiplex array
Cross-sectional baseline
Study Arms (2)
POAG Group
POAG patients who underwent filtering surgery, cataract surgery or MIGS.
Control Group
Healthy patients who underwent cataract surgery.
Interventions
Eligibility Criteria
POAG group and Control group are recruited from people who underwnt anti-glaucoma surgery and cataract surgery.
You may qualify if:
- Patients aged 18 years or older, diagnosed with primary open-angle glaucoma (POAG) and healthy controls (who underwent cataract surgery).
You may not qualify if:
- Other Ocular Diseases: Patients with concurrent ocular diseases such as macular degeneration, retinal detachment, etc., are excluded.
- Ocular Surgery History: individuals who have undergone intraocular or laser surgery within the past 6 months, except for uncomplicated cataract surgery.
- History of Ocular Trauma or Inflammation
- Systemic Diseases or Mental Disorders: Patients with systemic diseases(e.g., diabetes, rheumatoid arthritis) and those with mental disorders are excluded.
- Pregnancy or Lactation: Females who are pregnant or lactating are excluded.
- Presence of any retinal or optic nerve disease other than glaucoma.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Peking Universitylead
- Beijing Tongren Hospitalcollaborator
Study Sites (1)
Peking University Third Hosipital
Beijing, Beijing Municipality, 100191, China
Biospecimen
aqueous humor
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Chun Zhang, Ph.D.
Peking University Third Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 19, 2023
First Posted
January 5, 2024
Study Start
October 8, 2023
Primary Completion
December 31, 2023
Study Completion
April 1, 2024
Last Updated
January 5, 2024
Record last verified: 2023-12
Data Sharing
- IPD Sharing
- Will not share