Tracing MRSA in Households With Patients Infected With CA-MRSA by WGS

NCT04312776 | Completed

• 1 other identifier: SRRSH-Household01
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

From the 1980s to the late 1990s, highly toxic methicillin-resistant Staphylococcus aureus (MRSA) strains (called community-associated \[CA\] MRSA) appeared in the community. Although the prevalence of HA-MRSA (health-related MRSA) infection remained stable between 1998 and 2008, the CA-MRSA (community-related MRSA) infection rate increased. By far, the most common manifestations of CA-MRSA related diseases are skin and soft tissue infections. Skin and soft tissue infections (SSTIs) account for at least 90% of CA-MRSA infections. CA-MRSA strains also cause bone and joint infections, such as osteomyelitis and respiratory infections, such as pneumonia, sepsis, and urinary tract infections. Given that Staphylococcus aureus can live in the home as a settler or environmental pollutant, the environment can be used as a medium for obtaining and transmitting MRSA. In addition, transmission of MRSA between pets and humans has been proposed, but the directionality is unclear. In this study, we report an in-depth epidemiological and genomics study of a community-associated methicillin-resistant Staphylococcus aureus infection in SSRSH, Zhejiang Province, China.

Conditions

MRSA

Keywords

MRSA; Whole-genome sequencing

Outcome Measures

Primary Outcomes (1)

• Clonal Distribution of CA-MRSA in China The distribution of sequence types in CA-MRSA isolates from China

  During the study period (One years)

Study Arms (2)

Patients infected with CA-MRSA

It is an observational study, no interventions to any of the two study arms.

Other: none intervention

Healthy people without any infection

It is an observational study, no interventions to any of the two study arms.

Other: none intervention

Interventions

none intervention OTHER

Healthy people without any infection; Patients infected with CA-MRSA

Eligibility Criteria

• Age: 21 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

No special requirements

You may qualify if:

• Patients (Adult) with infections caused by S. aureus from the sites as follows: blood stream, skin or soft tissue, cerebrospinal fluid, bone and joint, genitourinary tract, infection of indwelling intravascular device, surgical wound, respiratory tract (organism grown from sputum and infiltrate on chest X-ray), peritoneal fluid or other otherwise sterile body fluids.

You may not qualify if:

• Patients with risk factors for nosocomial or medically related infections, and patients who have been decolonized (using mupirocin, chlorhexidine or bleach) in the past month.

Sponsors & Collaborators

• Sir Run Run Shaw Hospital: lead

Study Sites (1)

Sir Run Run Shaw Hospital

Hanzhou, Zhejiang, 310016, China

Location

Study Officials

• Yun-song Yu, MD

  Sir Run Run Shaw Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: March 16, 2020
• First Posted: March 18, 2020
• Study Start: November 15, 2019
• Primary Completion: March 17, 2020
• Study Completion: March 17, 2020
• Last Updated: March 18, 2020

Record last verified: 2020-03

Locations

CN (1)