NCT06183424

Brief Summary

In this study, the effects of bilateral stimulation of the dorsolateral prefrontal cortex (DLPFC) with active tDCS (transcranial direct stimulation/transcranial direct stimulation) on neurocognitive (memory and executive) functions in patients with Covid-19 infection and subjective cognitive complaints, as well as resting-state fMRI In the case of dfMRI, it is aimed to examine the default mode network (DMN) and parietal memory network (PMN) inter- and intra-network connectivity alterations and the hippocampal region connectivity alterations and contribute to the relevant literature.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
50

participants targeted

Target at P25-P50 for not_applicable covid19

Timeline
Completed

Started Oct 2023

Longer than P75 for not_applicable covid19

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2023

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

December 25, 2023

Completed
2 days until next milestone

First Posted

Study publicly available on registry

December 27, 2023

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2024

Completed
1.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2025

Completed
Last Updated

May 2, 2025

Status Verified

April 1, 2025

Enrollment Period

1 year

First QC Date

December 25, 2023

Last Update Submit

April 30, 2025

Conditions

COVID-19

Keywords

Covid-19tDCSCognitive function

Outcome Measures

Primary Outcomes (5)

  • Montreal cognitive assessment

    Cognition Test

    Before Treatment / 1 month after treathment

  • Cognition Test Material

    clock drawing test, digit range test, verbal fluency test, stroop test, trail making test

    Before Treatment / 1 month after treathment

  • NPI

    Cognition Test (Neuropsychiatric Inventory)

    Before Treatment / 1 month after treathment

  • Öktem Verbal Memory Processes Test

    Cognition Test

    Before Treatment / 1 month after treathment

  • Rey Complex Figure Test

    Cognition Test

    Before Treatment / 1 month after treathment

Study Arms (2)

Interventional

ACTIVE COMPARATOR

Active tDCS stimulation will be applied over the scalp for 20 minutes at an intensity of 2 mA. Stimulation will be given for 5 days. The application will be made to the patient who has had 30 Covid and has cognition complaints in a randomized manner.

Procedure: Transcranial Direct Stimulation

Sham

PLACEBO COMPARATOR

For the pseudo-stimulation to be applied to the sham group, the electrodes will be placed on the scalp in exactly the same way as the experimental group. For all stimulations, the reference electrode will be placed in the right orbital region and given once for 15 seconds, so that the participant will feel a slight tingling, but no real stimulation will be given.

Procedure: Transcranial Direct Stimulation

Interventions

Transcranial Direct StimulationPROCEDURE

2 mA, 20 min, 5 days

InterventionalSham

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Have received a positive value from the COVID-19 RT-PCR test in the last 60 days and turned negative
  • Being between the ages of 18-50
  • days have passed since the disease onset date

You may not qualify if:

  • Having any neurological or psychiatric disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Alanya Alaaddin Keykubat Üniversitesi

Antalya, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

COVID-19

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Electric Stimulation TherapyTherapeuticsConvulsive TherapyPsychiatric Somatic TherapiesBehavioral Disciplines and ActivitiesElectroshockPsychological Techniques

Study Officials

  • Burak Yuluğ, Prof. DR. MD

    Alanya Alaaddin Keykubat Üniversitesi

    STUDY DIRECTOR

Central Study Contacts

Cennet Sena Parlatan, phd Cand

CONTACT

05077799164cennet.parlatan@std.medipol.edu.tr

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Prof. Dr. MD

Study Record Dates

First Submitted

December 25, 2023

First Posted

December 27, 2023

Study Start

October 1, 2023

Primary Completion

October 1, 2024

Study Completion

December 1, 2025

Last Updated

May 2, 2025

Record last verified: 2025-04

Locations

TU(1)