Study Stopped
PI not workining at KUH anymore.
Ultrasound-guided Treatment in Acute Heart Failure
ECHO-AHF
Echocardiography and Lung Ultrasound Combined Into a Rapid Cardiothoracic Ultrasound Protocol (CaTUS) for Guiding Decongestive Treartment on a Day-to-day Basis in Patients Hospitalized for Acute Heart Failure With Pulmonary Congestion
1 other identifier
interventional
N/A
0 countries
N/A
Brief Summary
A randomized non-blinded study comparing ultrasound-guided therapy with conventional therapy in acute heart failure patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Mar 2019
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 13, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
November 30, 2020
CompletedFirst Submitted
Initial submission to the registry
December 13, 2023
CompletedFirst Posted
Study publicly available on registry
December 26, 2023
CompletedMarch 7, 2024
March 1, 2024
1.3 years
December 13, 2023
March 5, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Number of patients with re-hospitalization or death
post-discharge combined endpoint of re-hospitalization for acute heart failure or death due to any cause
6-months, also 3-months will be analyzed
Number of patients with re-hospitalization
Post-discharge re-hospitalization due to acute heart failure
6-months, also 3-months will be analyzed
Secondary Outcomes (1)
Number of patients with decongestion
during hospitalization
Study Arms (2)
Treatment arm
ACTIVE COMPARATORCongestive therapy will be guided by findings on daily cardiac- and lung ultrasound
Control Arm
SHAM COMPARATORThis arm will have the same ultrasound exams done daily as the treatment arm, but information will not be available for the treating physician for guiding therapy
Interventions
Combined echocardiography and lung ultrasound for guiding therapy
Eligibility Criteria
You may qualify if:
- Multiple bilateral B-lines as a sign of interstitial syndrome on lung ultrasound
- Elevated natriuretic peptide level
- Signs of elevated LVEDP on echocardiography
- Dyspnea at rest or ortophnea
You may not qualify if:
- eGFR \<25ml/min/1.73m2 or on dialysis
- Altered mental orientation
- Intubated
- Mitral stenosis or previous mitral valve procedure
- Chronic pulmonary parenchymal disease Pregnancy/breastfeeding
- Prisoners
- Patient under involuntary treatment
- Decision on study participation not made within 6 hours after receiving information regarding the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Masking Details
- Only the treating physician on the ward will know which arm the patient belongs to
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Clinical Professor
Study Record Dates
First Submitted
December 13, 2023
First Posted
December 26, 2023
Study Start
March 13, 2019
Primary Completion
June 30, 2020
Study Completion
November 30, 2020
Last Updated
March 7, 2024
Record last verified: 2024-03
Data Sharing
- IPD Sharing
- Will not share