Ejaculation Frequency and Semen Parameters

NCT06172504 | Unknown

• 1 other identifier: 2023-HS-134
• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to determine whether the frequency of ejaculation in men had an effect on semen parameters.. The main questions it aims to answer are:

• question 1：Whether the frequency of ejaculation has an effect on semen parameters
• question 2：Whether the penultimate abstinence period has an effect on semen parameters The participants were men who underwent semen examination in the andrology clinic of the Reproductive Center of the First Hospital of Jilin University. A brief medical history was collected from each volunteer, including demographic information, fertility history and as well as information regarding their general health.The focus of the investigation is the time of abstinence for this examination, the penultimate abstinence period, and the number of ejaculation since the last 1 month.

Conditions

Sperm; Fertility

Keywords

Semen Parameters; Ejaculation Frequency; the penultimate abstinence period

Outcome Measures

Primary Outcomes (5)

• Effect of ejaculation frequency on sperm DNA fragmentation rate

  The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm DNA fragment rate. Survey the basic information of the subjects and their frequency of ejaculation in the past month.The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups

  6 months

• Effect of ejaculation frequency on sperm motility rate

  The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm motility rate. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups

  6 months

• Effect of ejaculation frequency on total sperm count

  The subjects abstained for 3-7 days and masturbated to collect semen for measurement of total sperm count. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups

  6 months

• Effect of ejaculation frequency on sperm vitality rate

  The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm vitality rate. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups

  6 months

• Effect of ejaculation frequency on sperm morphology

  The subjects abstained for 3-7 days and masturbated to collect semen for measurement of sperm morphology. Survey the basic information of the subjects and their frequency of ejaculation in the past month. The frequency of ejaculation was divided into four groups:(1) 0-4 times/month; (2) 5-8 times/month; (3) 8-12 times/month; (4) \>12 times/month. The outcome was to compare whether there were differences in semen parameters between the groups

  6 months

Secondary Outcomes (1)

• Effect of the penultimate abstinence period on DNA fragmentation rate

  6 months

Eligibility Criteria

• Age: 22 Years - 45 Years
• Sex: male
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The participants were men who underwent semen examination in the andrology clinic of the Reproductive Center of the First Hospital of Jilin University. Including pre-conception, infertility, and his wife with a history of pregnancy loss.

You may qualify if:

• Normal ejaculation function, normal sexual life, masturbation can ejaculate
• Male age between 22 and 45 years old.
• According to World Health Organization standards, the semen examination time is within 48h to 7 days of abstinence.

You may not qualify if:

• The man was diagnosed with extremely severe oligospermia (sperm concentration \<1 million/ml) and azoospermia.
• Identify the factors affecting semen parameters, long-term exposure to high temperature, long-term exposure to chemicals, heavy metals, radiation and other toxic and harmful substances, orchitis/epididymitis, cryptorchidism, radiotherapy and chemotherapy treatment, and taking drugs to improve sperm within three months

Sponsors & Collaborators

• The First Hospital of Jilin University: lead

Study Sites (1)

the first hospital of Jilin University

Changchun, Jilin, 130000, China

RECRUITING

Related Publications (6)

• Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, Rienzi L, Sunde A, Schmidt L, Cooke ID, Simpson JL, van der Poel S. The International Glossary on Infertility and Fertility Care, 2017. Fertil Steril. 2017 Sep;108(3):393-406. doi: 10.1016/j.fertnstert.2017.06.005. Epub 2017 Jul 29.

  PMID: 28760517 BACKGROUND

• Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clin Biochem. 2018 Dec;62:2-10. doi: 10.1016/j.clinbiochem.2018.03.012. Epub 2018 Mar 16.

  PMID: 29555319 BACKGROUND

• Leisegang K, Dutta S. Do lifestyle practices impede male fertility? Andrologia. 2021 Feb;53(1):e13595. doi: 10.1111/and.13595. Epub 2020 Apr 24.

  PMID: 32330362 BACKGROUND

• Hanson BM, Aston KI, Jenkins TG, Carrell DT, Hotaling JM. The impact of ejaculatory abstinence on semen analysis parameters: a systematic review. J Assist Reprod Genet. 2018 Feb;35(2):213-220. doi: 10.1007/s10815-017-1086-0. Epub 2017 Nov 16.

  PMID: 29143943 BACKGROUND

• Barbagallo F, Cannarella R, Crafa A, Manna C, La Vignera S, Condorelli RA, Calogero AE. The Impact of a Very Short Abstinence Period on Conventional Sperm Parameters and Sperm DNA Fragmentation: A Systematic Review and Meta-Analysis. J Clin Med. 2022 Dec 8;11(24):7303. doi: 10.3390/jcm11247303.

  PMID: 36555920 BACKGROUND

• Stanford JB, White GL, Hatasaka H. Timing intercourse to achieve pregnancy: current evidence. Obstet Gynecol. 2002 Dec;100(6):1333-41. doi: 10.1016/s0029-7844(02)02382-7.

  PMID: 12468181 BACKGROUND

Study Officials

• yang yu

  The First Hospital of Jilin University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

yang yu, doctor

CONTACT

+86 13844000361; yuyang0351@jlu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 21, 2023
• First Posted: December 15, 2023
• Study Start: November 11, 2023
• Primary Completion: November 1, 2024
• Study Completion: November 1, 2024
• Last Updated: December 15, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)