Association Between Euploid Embryo Grade and Maternal Age

NCT06454058 | Terminated

• 1 other identifier: INC-IIS-2024-004
• Study Type: observational
• Target: 502
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Advanced maternal age (AMA) is associated with a reduction in live birth rate (LBR) after ART cycles. The main reason for this reduction is the lower number of oocytes aspirated, the number of developing embryos and the low number of euploid embryos available for transfer. The impact of age on success rates after the transfer of an euploid embryo has been a matter of discussion, with a recent meta-analysis showing a reduction in LBR after the transfer of an euploid blastocyst to women of AMA (1). There could be many reasons for this reduced LBR but they can be categorized into two broad categories - the uterus (including the mother's health) and the embryo (including the oocyte and the sperm). It is possible that factors associated with reduced embryo quality would manifest in a lower embryo grade.

Conditions

Fertility

Keywords

Advanced Maternal Age; Embryo Grade

Outcome Measures

Primary Outcomes (1)

• Embryo Grade

  Embryo grade for PGT-A confirmed euploid embryos

  6 months

Eligibility Criteria

• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who have completed IVF egg retrieval with PGT-A testing at a fertility clinic in The Prelude Network (US clinics, excluding NYU).

You may qualify if:

• Patients who have completed IVF egg retrieval with PGT-A testing at a fertility clinic in The Prelude Network (US clinics, excluding NYU)
• PGT biopsy was conducted in 2023,
• PGT biopsy was performed on blastocyst stage embryo,
• PGT-A result is euploid.

You may not qualify if:

• PGT-A result is mosaic,
• Embryos in which PGT-M was done and were found to be carriers of the mutation,
• Embryos in which PGT-SR was done and were found to be carriers of the structural rearrangement.

Sponsors & Collaborators

• Inception Fertility Research Institute, LLC: lead

Study Sites (1)

Inception Fertility Research Institute, LLC

Houston, Texas, 77081, United States

Location

Related Publications (1)

• Vitagliano A, Paffoni A, Vigano P. Does maternal age affect assisted reproduction technology success rates after euploid embryo transfer? A systematic review and meta-analysis. Fertil Steril. 2023 Aug;120(2):251-265. doi: 10.1016/j.fertnstert.2023.02.036. Epub 2023 Mar 5.

  PMID: 36878347 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 6, 2024
• First Posted: June 12, 2024
• Study Start: June 7, 2024
• Primary Completion: March 26, 2025
• Study Completion: March 26, 2025
• Last Updated: July 20, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)