A Phase I Study of NTQ1062 in Chinese Patients With Advanced Solid Tumors

NCT06172309 | Completed Phase 1

• 1 other identifier: NTQ1062-21101
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 2

Brief Summary

This is an open-label, single-arm, phase 1 study to evaluate the safety, tolerability, pharmacokinetics, and preliminary pharmacodynamic effect of NTQ1062 in patients with advanced solid tumors. The study comprises a dose-escalation phase and a dose-expansion phase.

1. 1.Dose-escalation:using 3+3 design to evaluate the safety, tolerability, and pharmacokinetic profile of NTQ1062 at 20, 50, 100, 200, 300, 400 mg in patients with advanced solid tumors, and to determine the maximum tolerated dose (MTD).
2. 2.Dose-expansion:the dose-expansion study will evaluate the safety, tolerability, and preliminary pharmacodynamic effect of the MTD for NTQ1062 in patients with advanced solid tumors, and to identify the recommended phase 2 dose (RP2D).

Conditions

Advanced Solid Tumors

Outcome Measures

Primary Outcomes (3)

• Maximum tolerated dose (MTD)

  The MTD is defined as the highest dose reached for which the incidence of dose limiting toxicity (DLT) occurs in less than 1/3 of the subjects.

  First treatment cycle (i.e., the first 28 days post the first dose)

• Recommended phase 2 dose (RP2D)

  The RP2D of NTQ1062 will be determined during the dose-escalation phase of the study. RP2D will be determined using available safety and pharmacokinetics and pharmacodynamics data.

  First treatment cycle (i.e., the first 28 days post the first dose)

• Adverse events

  Safety and tolerability of NTQ1062. Incidence of adverse events.

  through study completion, an average of 1 year

Secondary Outcomes (8)

• Pharmacokinetic parameters:Cmax

  At the end of Cycle 1 (each cycle is 28 days)

• Pharmacokinetic parameters: Tmax

  At the end of Cycle 1 (each cycle is 28 days)

• Pharmacokinetic parameters: AUC

  At the end of Cycle 1 (each cycle is 28 days)

• Pharmacokinetic parameters:T1/2

  At the end of Cycle 1 (each cycle is 28 days)

• Objective response rate (ORR)

  through study completion, an average of 1 year

Study Arms (1)

NTQ1062

EXPERIMENTAL

NTQ1062 Tablets will be administered orally QD in a 28-day cycle (21 days on treatment followed by 7 days off treatment) in sequential cohorts.

Drug: NTQ1062

Interventions

NTQ1062 DRUG

tablet(s) PO

NTQ1062

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged at least 18 years old, male or female patients.
• Patients with histologically and cytologically confirmed, advanced malignant solid tumors who have progressed on standard therapy or for whom no standard therapy exists, or for whom no standard treatment is available.
• (Dose escalation phase)Solid tumors that are at least one evaluable per Response Evaluation Criteria in Solid Tumors(RECIST v1.1);(Dose expansion phase)Solid tumors that are at least one measurable per Response Evaluation Criteria in Solid Tumors(RECIST v1.1).
• ECOG score is 0-1.
• Predicted life expectancy ≥3 months.
• Patients must have adequate organ function:
• Absolute neutrophil count (ANC) ≥ 1.5×109/L, platelet count ≥ 75×109/L, hemoglobin ≥ 85 g/L.
• Liver function: Total bilirubin ≤ 1.5xULN, AST and ALT ≤ 3.0xULN (≤ 5.0xULN for patients with Patients with hepatic metastases or hepatic carcinoma).
• Renal function:Creatinine (Cr) ≤ 1.5xULN or creatinine clearance (Ccr) ≥ 50 ml/min/1.73m2.
• Coagulation function: activated partial thromboplastin time (APTT) and INR ≤1.5×ULN.
• Female patients of child-bearing potential, and all male partners must consent to use a acceptable method of contraception throughout the study period and for 90 days after the last dose of either study drug.
• Patients must be signed written informed consent prior to admission to the study.

You may not qualify if:

• Clinically significant abnormalities of glucose metabolism as defined by any of the following:
• Diagnosis of diabetes mellitus type I.
• Baseline fasting glucose value of ≥8.33 mmol/l (150 mg/dL).
• Glycosylated haemoglobin (HbA1C) ≥8%.
• Patients who are still receive anti-tumor therapy such as chemotherapy, radiotherapy, biological therapy, endocrine therapy, immunotherapy and other anti-tumor drug from 4 weeks prior to the first dose.
• Patients have received previous treatment with a AKT,PI3K or mTOR inhibitor.
• Patients received strong inhibitors and/or inducers of CYP3A4 within 7 days prior to the first dose of study drug.
• Active infection requiring systemic treatment.
• Active hepatitis B virus infection or hepatitis C virus infection.
• History of human immunodeficiency virus infection.
• Patient has symptomatic CNS metastases.
• History of severe cardiovascular diseases.
• Other conditions that the investigator considers inappropriate for participation in this clinical trial

Sponsors & Collaborators

• Nanjing Chia-tai Tianqing Pharmaceutical: lead

Study Sites (2)

Shandong Cancer Hospital

Jinan, Shandong, 250000, China

Location

Shanghai East hospital

Shanghai, Shanghai Municipality, 200120, China

Location

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 23, 2023
• First Posted: December 15, 2023
• Study Start: September 24, 2021
• Primary Completion: April 20, 2024
• Study Completion: May 27, 2024
• Last Updated: July 29, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (2)