Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): Focusing on Brain Health and Sleep Quality

NCT06170073 | Completed

• 1 other identifier: 2023.496
• Study Type: observational
• Target: 238
• Locations: 1 country
• Sites: 1

Brief Summary

Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and therefore potentially model, the effects of sleep quality on cognition and brain health are of great pragmatic values.

Conditions

Sleep Disturbance; Aging; Cognitive Decline; Brain Disease

Keywords

Ageing; Sleep disturbances; Cognition; Brain health; Longevity

Outcome Measures

Primary Outcomes (3)

• Sleep quality will be measured by the Pittsburgh Sleep Quality Index (PSQI)

  Pittsburgh Sleep Quality Index (PSQI) is a validated 19-item self-reported questionnaire

  Baseline

• Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA)

  The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention.

  Baseline

• Complex attention will be measured by the Attention Network Test (ANT)

  The ANT paradigm, as a computerized test, was used and performed by E-Prime 3.0.

  Baseline

Secondary Outcomes (3)

• Memory and learning will be measured by the Word list learning test (WLLT)

  Baseline

• Executive functions will be measured by the category verbal fluency test (CVFT)

  Baseline

• The levels of Aβ40 and Aβ42 will be measured by saliva analysis

  Baseline

Study Arms (2)

Poor sleepers

With a total score of Pittsburgh Sleep Quality Index (PSQI) \> 5.

Good sleepers

With a total score of Pittsburgh Sleep Quality Index (PSQI) ≤ 5.

Eligibility Criteria

• Age: 55 Years - 95 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy normal ageing adults and adults with sleep disturbances.

You may qualify if:

• Chinese old adults are the ones who are over 60 years of chronological age.
• Sleep disturbance: individual's subjective sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI) with a total score \>5.

You may not qualify if:

• History of bipolar disorders or psychosis.
• History of major neurological deficits, including stroke, transient ischemic attack or brain tumor.
• Unable to participant magnetic resonance imaging (MRI) scanning.

Sponsors & Collaborators

• Chinese University of Hong Kong: lead
• The University of Hong Kong: collaborator

Study Sites (1)

The Chinese University of Hong Kong

Hong Kong, Tai Po District, 100000, Hong Kong

Location

Biospecimen

Retention: SAMPLES WITH DNA

Participant's saliva will be collected for further analysis.

MeSH Terms

Conditions

Parasomnias; Cognitive Dysfunction; Brain Diseases

Condition Hierarchy (Ancestors)

Sleep Wake Disorders; Nervous System Diseases; Mental Disorders; Cognition Disorders; Neurocognitive Disorders; Central Nervous System Diseases

Study Officials

• Hanna LU, PhD

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 6, 2023
• First Posted: December 14, 2023
• Study Start: October 1, 2023
• Primary Completion: December 31, 2024
• Study Completion: January 10, 2025
• Last Updated: January 14, 2025

Record last verified: 2025-01

Locations

HK (1)