Study of Predictors of Failure of Sulprostone Treatment in Postpartum Hemorrhage

NCT06164236 | Completed

• 1 other identifier: 8013
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators wish to identify potential factors predicting failure of second-line drug treatment (sulproston (Nalador®)): risk factors and factors linked to a failure to take initial care for PPH. A better understanding of the aggravating factors of HPP and more particularly the factors inherent to the initial care would make it possible to think of ways to improve practices.

Conditions

Postpartum Hemorrhage

Keywords

Postpartum haemorrhage; Maternal morbidity; Oxytocin; Sulprostone; Uterine Hemorrhage; Obstetric Labor Complications

Outcome Measures

Primary Outcomes (1)

• This a rétrospective study trayning to identify a potential predictors of failure of second-line drug treatment in the case of severe postpartum hemorrhage

  1 year

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult person (≥18 years old) who gave birth at HUS or at Poissy Saint-Germain-en Laye university hospital between 01/01/2019 and 12/31/2020 and having presented a postpartum hemorrhage treated with Sulprostone

You may qualify if:

• Major subject (≥18 years old)
• Subject having given birth at HUS or CHU Poissy Saint-Germain-en Laye between 01/01/2019 and 31/12/2020
• Subject having presented a postpartum haemorrhage treated with Sulprostone
• Subject not having expressed his opposition, after information, to the reuse of his data for the purposes of this research

You may not qualify if:

• Subject having expressed opposition to participating in the study
• Subject under guardianship or guardianship
• Subject under safeguard of justice

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

École de sages-femmes de Strasbourg

Strasbourg, Starsbourg, 67091, France

Location

Related Publications (1)

• Voillequin S, Meyer MN, Faraci F, Rozenberg MP, Rousseau A. Maternal and clinical characteristics associated with sulprostone failure in postpartum haemorrhage after vaginal delivery: A retrospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2026 Feb;317:114862. doi: 10.1016/j.ejogrb.2025.114862. Epub 2025 Nov 28.

  PMID: 41319511 DERIVED

MeSH Terms

Conditions

Postpartum Hemorrhage; Uterine Hemorrhage; Obstetric Labor Complications

Condition Hierarchy (Ancestors)

Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Puerperal Disorders; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Genital Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 2, 2020
• First Posted: December 11, 2023
• Study Start: October 19, 2020
• Primary Completion: April 19, 2024
• Study Completion: April 19, 2024
• Last Updated: December 27, 2024

Record last verified: 2024-12

Locations

FR (1)