Influence of Cardiorespiratory Fitness and Body Composition on Resting and Post-exercise Indices of Vascular Health in Young Adults

NCT06163456 | Completed

• 1 other identifier: 1810041426
• Study Type: interventional
• Target: 43
• Locations: 1 country
• Sites: 1

Brief Summary

This research is being done to determine whether acute exercise causes differences in numbers of novel blood factors associated with vascular health in college-aged adults across different physical activity habits. As only \~50% of cardiovascular (CV) events can be explained by traditional CV risk factors such as high blood pressure and high cholesterol, it is anticipated that this research will provide a more comprehensive look into novel risk factors that may better explain CV risk and that may be modifiable through regular physical activity.

Conditions

Endothelial Dysfunction; Arterial Stiffness

Outcome Measures

Primary Outcomes (2)

• endothelial function

  flow-mediated dilation

  Baseline and 60 min post-exercise

• arterial stiffness

  augmentation index

  Baseline and 60 min post-exercise

Study Arms (3)

low fitness

EXPERIMENTAL

Other: Acute submaximal exercise

moderate fitness

ACTIVE COMPARATOR

Other: Acute submaximal exercise

high fitness

ACTIVE COMPARATOR

Other: Acute submaximal exercise

Interventions

Acute submaximal exercise OTHER

30 min of treadmill running at 70% of the participants maximal oxygen consumption

high fitness; low fitness; moderate fitness

Eligibility Criteria

• Age: 18 Years - 29 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years of age; healthy male and female; Physically inactive, defined as participation in less than 20 min of continuous endurance exercise on fewer than 2 days/week; Recreationally active, defined as participation in 30 min/day of moderate-intensity cardiovascular activity on greater than 4 days/week; Highly active- defined as performing 30-60 min of moderate- to vigorous-intensity endurance exercise greater than 5 days/week.

You may not qualify if:

• currently pregnant, previously diagnosed coronary heart disease or congenital heart disease, serum total cholesterol \>200 mg/dl, low-density lipoprotein cholesterol \>130 mg/dl, high-density lipoprotein cholesterol \< 35 mg/dl, fasting glucose \>100 mg/dl, systolic blood pressure \> 130 mmHg, diastolic blood pressure \>90 mmHg, and BMI \>30 kg/m2.

Sponsors & Collaborators

• Towson University: lead

Study Sites (1)

Towson University

Towson, Maryland, 21252-0001, United States

Location

Study Officials

• Rian Q Landers-Ramos, PhD

  Towson University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: November 30, 2023
• First Posted: December 8, 2023
• Study Start: December 2, 2019
• Primary Completion: March 15, 2020
• Study Completion: November 29, 2023
• Last Updated: December 8, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)