Construction of Gynecological Tumor Organoids

NCT06155370 | Unknown

• 1 other identifier: K4903 G&O organoids
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study focuses on the construction of a biological sample library for organoids and tumor tissues in gynecological tumors.

Conditions

Gynecologic Cancer; Organoid

Outcome Measures

Primary Outcomes (1)

• Construction of BioBank

  BioBank including organoids banks, tissue banks, PDX banks, immune cell banks, and primary banks from other tissue sources

  one year

Secondary Outcomes (2)

• Drug sensitivity detection based on organoids banks

  one year

• Exploring the molecular mechanism based on organoids banks

  one year

Study Arms (6)

cohort of cervical cancer organoids

organoids derived from cervical cancer

Other: construction of organoids from gynecological tumor

cohort of endometrial cancer organoids

organoids derived from endometrial cancer

Other: construction of organoids from gynecological tumor

cohort of ovarian cancer organoids

organoids derived from ovarian cancer

Other: construction of organoids from gynecological tumor

cohort of vulva cancer organoids

organoids derived from vulva cancer

Other: construction of organoids from gynecological tumor

cohort of vaginal cancer organoids

organoids derived from vaginal cancer

Other: construction of organoids from gynecological tumor

cohort of gestational trophoblastic tumor organoids

organoids derived from gestational trophoblastic tumor

Other: construction of organoids from gynecological tumor

Interventions

construction of organoids from gynecological tumor OTHER

organoids construction

cohort of cervical cancer organoids; cohort of endometrial cancer organoids; cohort of gestational trophoblastic tumor organoids; cohort of ovarian cancer organoids; cohort of vaginal cancer organoids; cohort of vulva cancer organoids

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: female
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Those diagnosed with gynecological oncology, including cervical cancer, endometrial cancer, ovarian cancer, vulva cancer, vaginal cancer, and gestational trophoblastic tumor.

You may qualify if:

• Age of 18 or older, an informed consent form is provided;
• The preoperative tumor burden assessment and intraoperative researcher team believe that sampling is feasible;
• Having relevant requirements for sample library storage;
• Surgical treatment at Peking Union Medical College Hospital.

You may not qualify if:

• The research team considers any situations or considerations that may hinder normal pathological assessment.

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Biospecimen

Retention: SAMPLES WITH DNA

Biospecimen obtained from patients diagnosed with gynecological cancer from the cancer site.

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: November 23, 2023
• First Posted: December 4, 2023
• Study Start: December 1, 2023
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: December 4, 2023

Record last verified: 2023-11