Action Observation and Motor Imagery Therapy in Parkinson's Disease

NCT06154356 | Recruiting

• 1 other identifier: 09-2023/03
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

In recent years, motor imagery (MI) and action observation (AO) therapy strategies have been used in rehabilitation programs to increase motor learning in Parkinson's disease (PD). Visuomotor training strategies such as AO and MI therapy rely on the activity of the mirror neuron system to facilitate motor re-learning. Mirror neurons are activated during the performance of goal-directed actions, also when observing the same action and visualizing the action in the mind. The aim of this clinical trial is to test whether the application of AO and MI treatment in PD in addition to conventional rehabilitation programs has an additional effect on Balance, Functional Status and Quality of Life.

Conditions

Parkinson's Disease

Outcome Measures

Primary Outcomes (4)

• The difference in the scores of the Berg Balance Scale between pre- and post-rehabilitation assessments

  Univariate statistical analyses will be performed to calculate differences in the scores of the Berg Balance Scale between pre- and post-rehabilitation assessments. Berg Balance Scale consists of 14 items. Total score ranges from 0 to 56. Higher scores indicate better balance.

  6 weeks

• The difference in the scores of the The Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale pre- and post-rehabilitation assessments

  Univariate statistical analyses will be performed to calculate differences in the scores of the The Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale between pre- and post-rehabilitation assessments. The Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) consists of four sections: Part 1: non-motor experiences of daily living, Part 2: motor experiences of daily living, Part 3: motor examination, Part 4: motor complications. It consists of a total of 50 questions. In this study, sections II (motor experiences of daily living) and III (motor examination) will be used. Each item is is scored between 0 and 4. Higher values indicate that the patient's condition is worse.

  6 weeks

• The difference in the scores of the Timed Up and Go Test between pre- and post-rehabilitation assessments

  Univariate statistical analyses will be performed to calculate differences in the scores of the Timed Up and Go Test between pre- and post-rehabilitation assessments

  6 weeks

• The difference in the scores of the Five Times Sit to Stand Test between pre- and post-rehabilitation assessments

  Univariate statistical analyses will be performed to calculate differences in the scores of the Five Times Sit to Stand Test between pre- and post-rehabilitation assessments

  6 weeks

Secondary Outcomes (2)

• The difference in the scores of the Parkinson's Disease Questionnaire between pre- and post-rehabilitation assessments

  6 weeks

• The difference in the scores of the Freezing of Gait Questionnaire between pre- and post-rehabilitation assessments

  6 weeks

Study Arms (2)

Action observation and motor imagery therapy for rehabilitation

EXPERIMENTAL

Action observation and motor imagery therapy for rehabilitation in Parkinson's Disease in addition to conventional rehabilitation programs.

Other: Action observation and motor imagery therapy for rehabilitation

Sham action observation and motor imagery therapy for rehabilitation

SHAM COMPARATOR

Sham comparator for action observation and motor imagery therapy for rehabilitation in Parkinson's Disease in addition to conventional rehabilitation programs.

Other: Sham action observation and motor imagery therapy for rehabilitation

Interventions

Action observation and motor imagery therapy for rehabilitation OTHER

Action observation; Patients will watch some exercises accompanied by music from a previously prepared video for 10 minutes. Exercises include 8-10 repetitions of abduction-adduction, horizontal abduction-adduction, flexion-extension and supination-pronation movements for the upper extremity, and stepping, forward-backward stepping, side stepping and ankle dorsiflexion movements for the lower extremity. Motor imagery training; Patients will be asked to visualize the actions they watched in their minds for 10 minutes. Then the patients will watch the video again and will be asked to perform the exercises while watching.

Action observation and motor imagery therapy for rehabilitation

Sham action observation and motor imagery therapy for rehabilitation OTHER

Sham action observation; Patients will watch a video consisting of static nature photographs for 10 minutes with the same music. Sham motor imaginary; Patients will think about the video they watched for 10 minutes. Then, they will watch another video in which the exercises are performed only once, and they will be asked to do the exercises. They will be given enough time to do 8-10 repetitions.

Sham action observation and motor imagery therapy for rehabilitation

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with a diagnosis of Parkinson's Disease
• Hoehn and Yahr Stage 1-3

You may not qualify if:

• Patients with cognitive dysfunction (those who cannot follow simple verbal instructions)
• Patients with severe hearing problems
• Patients with severe vision problems
• Patients with additional musculoskeletal system pathology that will affect physical performance (such as amputation, severe joint mobility limitation, peripheral nerve damage)
• Patients with uncontrolled hypertension and diabetes mellitus
• Patients with a history of symptomatic lung disease (such as asthma, chronic obstructive pulmonary disease, emphysema)
• Patients with a history of symptomatic cardiac disease (such as coronary artery disease, arrhythmia, heart failure)

Sponsors & Collaborators

• Karaman Training and Research Hospital: collaborator
• Karamanoğlu Mehmetbey University: lead

Study Sites (1)

Karaman Training and Research Hospital

Karaman, Karaman, 70200, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Parkinson Disease

Interventions

Rehabilitation

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Yurdagul Bahran Mustu, MD.

  Karaman Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yurdagul Bahran Mustu, MD.

CONTACT

+90 506 209 76 72; yurdagulbahran@gmail.com

Aynur Basaran, MD, Prof.

CONTACT

aynurbasaran@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D., Principal investigator

Model Details: Prospective randomized controlled study

Study Record Dates

• First Submitted: November 23, 2023
• First Posted: December 4, 2023
• Study Start: December 14, 2023
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: December 11, 2025

Record last verified: 2025-12

Locations

TU (1)