Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes.

NCT06150105 | Completed

• 1 other identifier: 530/18
• Study Type: observational
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

One essential element of athlete training is conditioning camps, where athletes undergo a rigorous and targeted training schedule to prepare for upcoming sporting events. During sports camps, due to the accumulation of a large number of training units, including high-intensity exercises, athletes react with post-exercise overload, acute fatigue, and overreaching which can become a chronic overtraining syndrome. Overtraining syndrome is a very specific and severe condition where overtraining without adequate rest and recovery leads to performance decrements lasting more than 2-3 months, coupled with a mood disturbance. The exact etiology and pathogenesis are unknown and actively being investigated. During training camps the balance between training volumes and recovery is often a delicate one and, the accumulation of exercise-induced stress may exceed the capacity of both neuroendocrine and immune adaptation leading to an alteration of physiological functions, decreasing adaptation to performance, impairment of psychological processing, immunological dysfunction, and biochemical abnormalities. Moreover, there is currently a lack of biomarkers accessible to assist in diagnosing and, what's even more important - help to prevent the overtraining syndrome, except for the continued presence of unexplained underperformance despite athletes' adequate rest and recovery. Thus, this study aims to explain how long and intensive training for endurance affects the hormonal and immune systems of young athletes. The main questions it aims to answer are:

1. 1.How does intense training influence hormonal and immune responses in young, trained athletes?
2. 2.Does training specialization affect the hormonal and immune response to intense training?

Conditions

Overtraining Syndrome

Keywords

epinephrine, norepinephrine, cortisol, athletes, fatigue

Outcome Measures

Primary Outcomes (5)

• Changes in epinephrine serum level.

  marker of HPA axis functioning, stress hormone.

  at rest baseline (before training), after 4 - and after another 5 days of training.

• Changes in norepinephrine serum level.

  marker of HPA axis functioning, stress hormone.

  at rested baseline (before training), after 4 - and after another 5 days of training.

• Changes in cortisol serum level.

  marker of HPA axis functioning, stress hormone

  at rested baseline (before training), after 4 - and after another 5 days of training.

• Changes in hs-CRP serum level.

  marker of inflammatory response.

  at rested baseline (before training), after 4 - and after another 5 days of training.

• Changes in Myoglobin serum level.

  marker of muscle damage

  at rested baseline (before training), after 4 - and after another 5 days of training.

Secondary Outcomes (2)

• Changes in blood morphology.

  sat rested baseline (before training), after 4 - and after another 5 days of training.

• Changes in epinephrine/norepinephrine ratio.

  at rested baseline (before training), after 4 - and after another 5 days of training.

Study Arms (2)

sprint-trained

Sprint-trained athletes: 6 male and 6 female, aged average 15 y.,

Other: Exercise training

endurance-trained

Endurance-trained athletes: 6 male and 6 female, aged average 15 y.,

Other: Exercise training

Interventions

Exercise training OTHER

Intense endurance training

endurance-trained; sprint-trained

Eligibility Criteria

• Age: 15 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Twenty-four young male and female athletes, students at Sports Championship School, future representatives of the Polish National Team, specializing in athletics disciplines such as sprint (hurdles, 100m, 110m), and endurance: race walk, 5000m, and 10000m, volunteered to take part in this study.

You may qualify if:

• age 15-17 years,
• minimum of 3 years of training experience,
• specialization in anaerobic and aerobic disciplines.

You may not qualify if:

• presence of acute or chronic inflammation
• fever, infections, injuries
• se of any anti-inflammatory drugs.

Sponsors & Collaborators

• Poznan University of Physical Education: lead

Study Sites (1)

Poznań University of Physical Education

Poznan, 61-871, Poland

Location

Related Publications (1)

• Ostapiuk-Karolczuk J, Kasperska A, Dziewiecka H, Cieslicka M, Zawadka-Kunikowska M, Zaleska-Posmyk I. Changes in the hormonal and inflammatory profile of young sprint- and endurance-trained athletes following a sports camp: a nonrandomized pretest-posttest study. BMC Sports Sci Med Rehabil. 2024 Jun 20;16(1):136. doi: 10.1186/s13102-024-00924-3.

  PMID: 38898468 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples

MeSH Terms

Conditions

Overtraining Syndrome; Fatigue

Interventions

Exercise

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Joanna Ostapiuk-Karolczuk, Ph.D.

  Poznan University of Physical Education

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 13, 2023
• First Posted: November 29, 2023
• Study Start: February 16, 2018
• Primary Completion: February 24, 2018
• Study Completion: December 10, 2018
• Last Updated: December 6, 2023

Record last verified: 2023-11

Locations

PL (1)