The Relationship of Serum Uric Acid With Severity of Knee Osteoarthritis

NCT06149078 | Unknown

• 1 other identifier: Soh-Med-23-11-10MS
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Osteoarthritis (OA) is the most prevalent form of arthritis. Its pathogenesis remains poorly understood. Though historically regarded as a disease of mechanical degeneration, it is now appreciated that inflammation plays an important role in OA pathogenesis (Krasnokutsky et al., 2017). The hallmark of OA is the degradation and loss of articular cartilage, although most tissues of the joint become affected, such as bone, synovium, ligaments, menisci (knee), labrum (hip), periarticular fat, and muscle (Englund, 2023).It is believed that there is a pathological link between hyperuricemia and OA Therefore, we conducted a cross-sectional study to evaluate an association between elevated SUA and radiographic OA of the knee) Bipan Shrestha, 2019 (.

Conditions

Knee Osteoarthritis

Outcome Measures

Primary Outcomes (1)

• percentage of serum uric acid

  detect the relationship of serum uric acid with severity of knee osteoarthritis

  6 months

Study Arms (2)

cases group

hyperurecemic

Diagnostic Test: serum uric acid

control group

normal

Diagnostic Test: serum uric acid

Interventions

serum uric acid DIAGNOSTIC_TEST

to detect the relaton ship of serum uric acid with sevwrity of knee osteoarthritis

cases group; control group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

\- Adult patient (Age\>18 years) with a complaint of knee pain.

You may qualify if:

• Adult patient (Age\>18 years) with a complaint of knee pain.

You may not qualify if:

• Any patient with a history of trauma to the knee. 2 Any patient with knee complaints as a part of autoimmune connective tissue disease.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university Hospital

Sohag, Egypt

Location

Related Publications (3)

• Englund M. Osteoarthritis, part of life or a curable disease? A bird's-eye view. J Intern Med. 2023 Jun;293(6):681-693. doi: 10.1111/joim.13634. Epub 2023 Apr 2.

  PMID: 37004213 BACKGROUND

• Krasnokutsky S, Oshinsky C, Attur M, Ma S, Zhou H, Zheng F, Chen M, Patel J, Samuels J, Pike VC, Regatte R, Bencardino J, Rybak L, Abramson S, Pillinger MH. Serum Urate Levels Predict Joint Space Narrowing in Non-Gout Patients With Medial Knee Osteoarthritis. Arthritis Rheumatol. 2017 Jun;69(6):1213-1220. doi: 10.1002/art.40069. Epub 2017 Apr 28.

  PMID: 28217895 BACKGROUND

• Park D, Park YM, Ko SH, Hyun KS, Choi YH, Min DU, Han K, Koh HS. Association of general and central obesity, and their changes with risk of knee osteoarthritis: a nationwide population-based cohort study. Sci Rep. 2023 Mar 7;13(1):3796. doi: 10.1038/s41598-023-30727-4.

  PMID: 36882508 BACKGROUND

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Central Study Contacts

Aya M Saber, resident

CONTACT

01278825940; ayamohamed@med.sohag.edu.eg

Abdullah M Ahmed, assistant professor

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident at Physical Medicine , Rheumatology and rehabilitation department

Study Record Dates

• First Submitted: November 20, 2023
• First Posted: November 28, 2023
• Study Start: December 10, 2023
• Primary Completion: May 10, 2024
• Study Completion: May 10, 2024
• Last Updated: November 28, 2023

Record last verified: 2023-11

Locations

EG (1)