Can Urinary Partial Oxygen Pressure be an Indicator of Acute Kidney Injury in Patients With Sepsis?

NCT06124105 | Not Yet Recruiting

• 1 other identifier: MB2
• Study Type: interventional
• Target: 68
• Locations: 0 countries
• Sites: N/A

Brief Summary

The ability of bladder urinary partial pressure, measured as a reflection of renal medullary oxygen tension, which is an indicator of the development of acute kidney injury (AKI), to predict the development of AKI at an early stage.

Conditions

Acute Kidney Injury; Sepsis

Keywords

acute kidney injrury, sepsis, urine parcial oxygen pressure

Outcome Measures

Primary Outcomes (1)

• acute kidney injury

  urine partial oxygen pressure in arterial blood gases

  first 5 days

Secondary Outcomes (1)

• mortality

  28. days

Study Arms (1)

urine PO2

OTHER

Diagnostic Test: arterial blood gases

Interventions

arterial blood gases DIAGNOSTIC_TEST

measurement of partial oxygen pressure in urine by arterial blood gas device

urine PO2

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients admitted to intensive care unit with sepsis

You may not qualify if:

• Causing an infection other than sepsis at the time of admission
• Acute renal failure at the time of admission
• Having a creatinine value above 1.5 mg/dL at the time of admission
• Previously known chronic renal failure or being on a routine dialysis programme (receiving renal replacement therapy)
• Having one kidney
• Having another known kidney disease

Sponsors & Collaborators

• Inonu University: lead

Related Publications (3)

• Osawa EA, Cutuli SL, Bitker L, Canet E, Cioccari L, Iguchi N, Lankadeva YR, Eastwood GM, Evans RG, May CN, Bellomo R. Effect of Furosemide on Urinary Oxygenation in Patients with Septic Shock. Blood Purif. 2019;48(4):336-345. doi: 10.1159/000501512. Epub 2019 Jul 23.

  PMID: 31336370 BACKGROUND

• Silverton NA, Lofgren LR, Hall IE, Stoddard GJ, Melendez NP, Van Tienderen M, Shumway S, Stringer BJ, Kang WS, Lybbert C, Kuck K. Noninvasive Urine Oxygen Monitoring and the Risk of Acute Kidney Injury in Cardiac Surgery. Anesthesiology. 2021 Sep 1;135(3):406-418. doi: 10.1097/ALN.0000000000003663.

  PMID: 34329393 BACKGROUND

• Evans RG, Cochrane AD, Hood SG, Iguchi N, Marino B, Bellomo R, McCall PR, Okazaki N, Smith JA, Zhu MZ, Ngo JP, Noe KM, Martin A, Thrift AG, Lankadeva YR, May CN. Dynamic responses of renal oxygenation at the onset of cardiopulmonary bypass in sheep and man. Perfusion. 2022 Sep;37(6):624-632. doi: 10.1177/02676591211013640. Epub 2021 May 12.

  PMID: 33977810 BACKGROUND

MeSH Terms

Conditions

Acute Kidney Injury; Sepsis

Interventions

Blood Gas Analysis

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Blood Chemical Analysis; Clinical Chemistry Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Investigative Techniques

Central Study Contacts

murat bıçakcıoğlu

CONTACT

05327901791; drmuratft@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: study group: patients who develop aki in sepsis

Study Record Dates

• First Submitted: November 6, 2023
• First Posted: November 9, 2023
• Study Start: March 6, 2024
• Primary Completion: October 15, 2024
• Study Completion: December 15, 2024
• Last Updated: March 7, 2024

Record last verified: 2024-03