Testing the Interplay of Gambling, Emotion and Reward
TIGER
1 other identifier
observational
120
1 country
1
Brief Summary
Background The nature and direction of dysfunctional reward processing in gambling disorder remains unclear. We aim to test a novel neurobiological model of gambling addiction, that takes into account inter-individual differences, as well as the multifactorial nature of gaming addiction. Objectives Primary objective: This project will test the hypothesis that there are two opposite brain phenotypes that characterize two distinct subpopulations of gamblers, so-called impulsive vs. emotional, respectively. Secondary objective: This project will also seek to determine whether the brain phenotypes proposed above are capable of predicting gambling behavior outside the laboratory. Study design The primary objective will be tested using a reward task and a facial emotion recognition task performed by participants in an fMRI scanner. The secondary objective will be tested by combining fMRI measures with behavioral measures from everyday life collected via Ecological Momentary Assessment (EMA). Study population This study will focus on individuals with gambling problems, as well healthy subjects with no gambling problems and no psychiatric comorbidities. Outcomes/Endpoints Primary endpoint: We will compare striatum and amygdala reactivity between the three groups of impulsive gamblers, emotional gamblers and healthy subjects. Secondary endpoint: We will assess the correlation between emotional states and gambling behavior in everyday life, based on striatum and amygdala reactivity, using multiple linear regression models.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Mar 2024
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 28, 2023
CompletedFirst Posted
Study publicly available on registry
November 8, 2023
CompletedStudy Start
First participant enrolled
March 27, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 20, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 20, 2028
July 17, 2025
July 1, 2025
3.1 years
September 28, 2023
July 16, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Striatal BOLD response to reward outcomes and amygdala BOLD response to emotional stimuli
Striatal BOLD response: average BOLD signal as measured with fMRI in the striatum in response to monetary reward outcomes in a gambling task. amygdala BOLD response: average BOLD signal as measured with fMRI in the amygdala in response to emotional faces in a facial emotion recognition task.
4 weeks
Secondary Outcomes (1)
Correlation between emotional states and gambling behavior in everyday life
4 weeks
Study Arms (2)
Individuals with gambling problems
This group includes individuals suffering from gambling addiction as defined by the DSM-5, and individuals suffering from "problem gambling", just below the DSM-5 diagnostic threshold.
Healthy control individuals
Matched healthy individuals
Interventions
A brain imaging technique that measures in vivo the activity of brain areas by detecting local changes in blood flow.
studies people's thoughts and behaviour in their daily lives by repeatedly collecting data in an individual's normal environment, at or close to the time they carry out that behaviour
Eligibility Criteria
Two groups: 60 individuals with gambling problems (i.e. Number of DSM-5 critera for gambling disorder ≥3) and 60 matched healthy controls
You may qualify if:
- For all participants (gamblers and healthy subjects)
- Aged between 18 and 65
- Fluent French, read and spoken
- Male and Female
- Informed consent to take part in the research
- For gamblers :
- Number of DSM-5 critera for gambling disorder ≥3
- Score ≥ 5 on the Problem Gambling Severity Index questionnaire (PGSI)
- Have a smartphone
- For healthy subjects :
- no DSM-5 criteria for gambling addiction
- Score ≤ 2 on the Problem Gambling Severity Index questionnaire (PGSI)
You may not qualify if:
- For all participants (gamblers and healthy subjects):
- Contra-indication to MRI
- Protected Adults
- Breast feeding or pregnant women
- Neurological disorder or severe chronic illness (diabetes, heart disease, kidney disease, lung disease or liver disease, inflammatory disease….)
- Pharmacological treatment with psychotropic action (\>1 time / week)
- Regular drug use (\> 1 time/ week for at least 3 months in the last 6 months)
- Positive urine drug test on the day of the MRI sessions
- For gamblers:
- Psychiatric treatment \> 1 month (pharmacological or CBT)
- Other DSM-5 diagnosis : schizophrenia, bipolar disorder, ADHD, autism, current PTSD, eating disorders, current major depressive episode, anxiety disorder, substance use disorder except nicotine, obsessive compulsive disorder.
- For healthy subjects :
- \- Any DSM-5 diagnosis except nicotine addiction
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CH le Vinatier
Bron, 69678, France
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Guillaume SESCOUSSE, PHD
CH Le Vinatier
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 28, 2023
First Posted
November 8, 2023
Study Start
March 27, 2024
Primary Completion (Estimated)
May 20, 2027
Study Completion (Estimated)
May 20, 2028
Last Updated
July 17, 2025
Record last verified: 2025-07
Data Sharing
- IPD Sharing
- Will not share