Effects of Posterior Parietal Cortex and Cerebellum Anodal tDCS on Ankle Tracking Visuomotor Adaptation

NCT06122155 | Completed

• 1 other identifier: 202204075DINB
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Motor adaptation is guided by state estimation, a dynamic prediction of the interaction consequences between body and environment in the sensorimotor system. Previous studies have shown that the posterior parietal cortex (PPC) and cerebellum are potential candidates for state estimators. However, neither direct evidence linking neural substrates of state estimation and motor adaptation nor the differences in state estimation in these two brain areas was presented. A comparison of neuromodulation effects over PPC and cerebellum in motor adaptation tasks could provide direct evidence to solve the knowledge gap. Objective: This study aims to provide direct evidence to link state estimation and motor adaptation, and the neuromodulation effects of PPC and cerebellum in motor adaptation by using anodal transcranial direct current stimulation.

Conditions

Transcranial Direct Current Stimulation

Keywords

Transcranial Direct Current Stimulation

Outcome Measures

Primary Outcomes (2)

• Block root-mean squared error (RMSE)

  RMSE is the error between target trajectory and subject cursor trajectory. Every 5 trials of RMSE were averaged into one block.

  2 hours during the time of assessment of the participant

• RMSE reduction rate

  ΔRMSEi-(i+1) = (RMSEi - RMSEi+1) / RMSEi x 100%

  2 hours during the time of assessment of the participant

Study Arms (3)

Posterior parietal cortex (PPC)

EXPERIMENTAL

In the motor adaptation phase, a 20-minute, 2 mA anodal tDCS was delivered through two 5cm x 7cm electrodes using the DC-STIMULATOR MR (neuroConn, Germany). The electrical current gradually ramps up and down in 20 seconds. In the PPC group, the anodal electrode was placed over the P3 or P4 areas on the skull, covering the PPC area on the opposite side of the testing foot (according to the international 10-20 EEG system), and the reference electrode was placed over the supraorbital region on the same side of the testing foot.

Device: Transcranial direct current stimulation (Anodal)

Cerebellum

EXPERIMENTAL

In the motor adaptation phase, a 20-minute, 2 mA anodal tDCS was delivered through two 5cm x 7cm electrodes using the DC-STIMULATOR MR (neuroConn, Germany). The electrical current gradually ramps up and down in 20 seconds. In the cerebellum group, the anodal electrode was placed 1\~2 cm under and 3\~4 cm lateral to the inion on the same side of the testing foot, with the reference electrode placed on the buccinator on the same side of the testing foot.

Device: Transcranial direct current stimulation (Anodal)

Sham

SHAM COMPARATOR

In the motor adaptation phase, a 20-minute, 0 mA anodal tDCS was delivered through two 5cm x 7cm electrodes using the DC-STIMULATOR MR (neuroConn, Germany) for the sham group. Participants were informed that they might experience itchiness, burning, or mild discomfort during the tDCS period regardless of which group they were assigned to, so they would not use their sensation as a basis for determining whether they received actual stimulation or not.

Device: Transcranial direct current stimulation (Sham)

Interventions

Transcranial direct current stimulation (Anodal) DEVICE

20-minutes, 2 mA anodal tDCS delivering through two 5 cm x 7 cm electrodes

Cerebellum; Posterior parietal cortex (PPC)

Transcranial direct current stimulation (Sham) DEVICE

20-minutes, 0 mA anodal tDCS delivering through two 5 cm x 7 cm electrodes

Sham

Eligibility Criteria

• Age: 20 Years - 29 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• age between 20\~29 years old
• normal ankle range of motion and muscle strength
• intact cognitive function (Mini-mental State Examination (MMSE) \>27)
• corrected vision \> 0.9.

You may not qualify if:

• any neurologic or psychiatric disease history
• musculoskeletal disease that interferes lower extremities movement
• severe cardiopulmonary or systematic disease (e.g. unstable angina, severe arrhythmia, heart failure, hypertrophic cardiomyopathy, aortic stenosis, pulmonary embolism, kidney failure)
• paresthesia
• seizure history
• brain surgery, meningitis, encephalitis history
• drainage tube on the head
• metal or other insertion in the brain
• insertion of electric medical device (e.g. pacemaker, cochlear implant)
• pregnancy
• taking central nervous system medication (e.g. antidepressants, anxiolytic)
• alcoholic addiction or drug abuse
• open wound, allergy, rash, or other illness that would affect the placement of tDCS
• headache, disgusting, vomit, or any other severe side effect to the tDCS

Sponsors & Collaborators

• National Taiwan University Hospital: lead
• National Science and Technology Council: collaborator

Study Sites (1)

National Taiwan University

Taipei, 100, Taiwan

Location

MeSH Terms

Interventions

Transcranial Direct Current Stimulation

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 29, 2023
• First Posted: November 8, 2023
• Study Start: November 26, 2022
• Primary Completion: June 19, 2023
• Study Completion: June 19, 2023
• Last Updated: November 14, 2023

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)