Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit

NCT06121115 | Completed

• 1 other identifier: 2022-06476
• Study Type: observational
• Target: 473
• Locations: 1 country
• Sites: 1

Brief Summary

This is a single-center study retrospectively evaluating a local clinical routine to administer norepinephrine in midline catheters, with regard to complications and patient outcomes

Conditions

Septic Shock; Norepinephrine Adverse Reaction; Hypotension and Shock

Keywords

vasopressor; norepinephrine; septic shock; midline catheter; thrombosis; extravasation; catheter-related bloodstream infection

Outcome Measures

Primary Outcomes (1)

• Proportion of patients with a major complication of norepinephrine administration in midline

  extravasation of norepinephrine, midline-associated bloodstream infection, thrombosis

  day 30

Secondary Outcomes (3)

• Proportion of patients with a minor complication of norepinephrine administration in midline

  day 30

• Proportion of patients receiving a CVC after midline

  day 30

• Proportion of patients with different intermediary care unit outcomes

  day 30

Interventions

Norepinephrine DRUG

Norepinephrine administered in midline catheter according to clinical routine

Also known as: Vasopressors

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population are critically ill patients in need of vasopressors, primarily with septic shock.

You may qualify if:

• Administration of norepinephrine in a midline catheter in an intermediary care unit
• In Skåne university hospital
• From 2019 to 2023-03-31

You may not qualify if:

• Patients who have actively disabled review of their electronic medical record

Sponsors & Collaborators

• Region Skane: lead

Study Sites (1)

Skåne University Hospital

Malmo, Sweden

Location

Related Publications (1)

• Karlsson H, Afrasiabi A, Ohlsson M, Mansson V, Hartman H, Torisson G. Treating shock with norepinephrine administered in midline catheters in an intermediary care unit: a retrospective cohort study. BMJ Open. 2024 Dec 30;14(12):e091311. doi: 10.1136/bmjopen-2024-091311.

  PMID: 39806688 DERIVED

MeSH Terms

Conditions

Shock, Septic; Hypotension; Shock; Thrombosis

Interventions

Norepinephrine; Vasoconstrictor Agents

Condition Hierarchy (Ancestors)

Sepsis; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Vascular Diseases; Cardiovascular Diseases; Embolism and Thrombosis

Intervention Hierarchy (Ancestors)

Ethanolamines; Amino Alcohols; Alcohols; Organic Chemicals; Amines; Biogenic Monoamines; Biogenic Amines; Catecholamines; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Cardiovascular Agents; Therapeutic Uses; Pharmacologic Actions; Chemical Actions and Uses

Study Officials

• Gustav Torisson, PhD

  Region Skåne

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 3, 2023
• First Posted: November 7, 2023
• Study Start: October 3, 2023
• Primary Completion: March 1, 2024
• Study Completion: March 1, 2024
• Last Updated: March 12, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)