Prediction of UA/SOD Ratio as a Biomarker of Oxidative Stress in Atrial Fibrillation

NCT06119802 | Unknown

• 1 other identifier: YXLL-KY-2023(044)
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

To clarify the predictive effects of uric acid and superoxide dismutase as biomarkers of oxidative stress on atrial fibrillation, and to provide greater value for the diagnosis and prediction of atrial fibrillation. It provides a new idea for the prevention and treatment of atrial fibrillation.

Conditions

Atrial Fibrillation; Hyperuricemia

Keywords

hyperuricemia; atrial fibrillation

Outcome Measures

Primary Outcomes (1)

• Uric acid/SOD ratio is associated with atrial fibrillation

  Uric acid/SOD ratio is associated with atrial fibrillation

  3 years

Study Arms (2)

Atrial Fibrillation cohort

The diagnosis of AF was based on 12-lead electrocardiography (ECG) or 24-hour Holter monitoring, and classification was based on the published 2020 ESC guidelines for the diagnosis and management of AF. The exclusion criteria were as follows: (1) acute heart failure and acute myocardial infarction; (2) severe liver or kidney dysfunction (with aspartate aminotransferase or alanine aminotransferase levels three times higher than normal and estimated glomerular filtration rate \<30 ml/ (min\*1.73 m2)); (3) malignant tumors; and (4) missing data of laboratory indicators at baseline.

Diagnostic Test: atrial fibrillation

Non-atrial Fibrillation cohort

Patients attending the Department of Cardiology to rule out atrial fibrillation.The exclusion criteria were as follows: (1) acute heart failure and acute myocardial infarction; (2) severe liver or kidney dysfunction (with aspartate aminotransferase or alanine aminotransferase levels three times higher than normal and estimated glomerular filtration rate \<30 ml/ (min\*1.73 m2)); (3) malignant tumors; and (4) missing data of laboratory indicators at baseline.

Interventions

atrial fibrillation DIAGNOSTIC_TEST

ECG of atrial fibrillation last more than 30 seconds.

Atrial Fibrillation cohort

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This retrospective study enrolled all hospitalized patients from January 2018 to December 2020 at the Department of Cardiology in The First Affiliated Hospital of Shandong First Medical University.

You may not qualify if:

• acute heart failure and acute myocardial infarction;
• severe liver or kidney dysfunction (with aspartate aminotransferase or alanine aminotransferase levels three times higher than normal and estimated glomerular filtration rate \<30 ml/ (min\*1.73 m2));
• malignant tumors;
• missing data of laboratory indicators at baseline.

Sponsors & Collaborators

• Yinglong Hou: lead

Study Sites (1)

Shandong provincal Qianfoshan hospital

Jinan, Shandong, 250014, China

RECRUITING

MeSH Terms

Conditions

Atrial Fibrillation; Hyperuricemia

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Hui Tian, PhD

  Qianfoshan Hospital

  STUDY CHAIR

Central Study Contacts

Yinglong Hou, PhD

CONTACT

13791120810; yujiao61@163.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: September 6, 2023
• First Posted: November 7, 2023
• Study Start: January 1, 2022
• Primary Completion: October 31, 2023
• Study Completion: April 30, 2024
• Last Updated: November 7, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)