Association Between ALDH2 Gene Polymorphism and Atrial Fibrillation

NCT05524142 | Unknown

• 1 other identifier: 2022-0404
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a case-control study. In this study, 2ml of vein blood samples were collected from patients with atrial fibrillation undergoing radiofrequency ablation and those in the control group who underwent electrophysiological examination alone and confirmed no arrhythmia. The purpose of this study is to identify the relationship between the aldehyde dehydrogenase 2 (ALDH2) gene polymorphism and susceptibility to atrial fibrillation, and to explore the relationship between the genotype of ALDH2 SNP and the prognosis of patients with atrial fibrillation undergoing radiofrequency ablation.

Conditions

Atrial Fibrillation

Keywords

atrial fibrillation; ALDH2

Outcome Measures

Primary Outcomes (1)

• atrial fibrillation recurrence

  atrial fibrillation recurrence

  3 months

Study Arms (2)

Atrial fibrillation

Patients with atrial fibrillation underwent radiofrequency ablation.

Control

Patients underwent electrophysiological examination alone and were confirmed no arrhythmia.

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients diagnosed with atrial fibrillation in the Second Affiliated Hospital of Zhejiang University School of Medicine.

You may qualify if:

• Signed informed consent;
• Age 18-85 years old, gender is not limited; ③ Case group: patients with clinical diagnosis of atrial fibrillation who underwent radiofrequency ablation; control group: patients with no arrhythmia confirmed by electrophysiological examination; ④ Able to communicate well with investigators and comply with the entire trial requirements.

You may not qualify if:

• Those who cannot understand or refuse to sign the informed consent or follow-up; ②Pregnant women, mentally retarded, mental/cognitive insufficiency and other possible vulnerable groups

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Study Sites (1)

The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310009, China

RECRUITING

Related Publications (1)

• Jin J, Qian N, Gao Y, Liu J, Chen D, Wang B, Luo M, Zhang Y, Ye J, Jiang R, Wang L, Jiang J, Wang Y. Diabetes and ALDH2 Gene Polymorphism on Post-Ablation Atrial Fibrillation Recurrence. JACC Asia. 2025 Nov 12:S2772-3747(25)00638-6. doi: 10.1016/j.jacasi.2025.10.021. Online ahead of print.

  PMID: 41342828 DERIVED

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Yaping o Wang

CONTACT

+8613805725837; yapingwang@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 30, 2022
• First Posted: September 1, 2022
• Study Start: May 20, 2022
• Primary Completion: December 31, 2023
• Study Completion: June 30, 2024
• Last Updated: September 1, 2022

Record last verified: 2022-08

Locations

CN (1)