Surgical Treatment and Molecular Marker Exploration of Locally Recurrent Colorectal Cancer

NCT06114420 | Unknown

• 1 other identifier: CancerIHCAMS-NCC4237
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This study intends to explore the clinicopathological characteristics and survival prognosis of locally recurrent colorectal cancer patients with different treatment modes by retrospectively analyzing the medical records of locally recurrent colorectal cancer patients who received hospitalization in our center. Transcriptome sequencing and public databases were used to screen for molecular markers related to locally recurrent colorectal cancer and to explore molecular markers' regulatory role in the progression of locally recurrent colorectal cancer.

Conditions

Locally Recurrent Colorectal Cancer

Outcome Measures

Primary Outcomes (2)

• Overall survival

  3-years

• Cancer-specific survival

  3-years

Secondary Outcomes (1)

• Find a differentially expressed gene

  3-years

Study Arms (2)

patients with local recurrence

Procedure: salvage surgery

patients without local recurrence

Interventions

salvage surgery PROCEDURE

Some patients who cannot undergo surgery

Also known as: adjuvant treatment

patients with local recurrence

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with locally recurrent colorectal cancer who underwent surgery during hospitalization and whose primary surgical pathology was stage II/III.

You may qualify if:

• Patients with LRCRC who received hospitalization in our center and patients with stage II-III colorectal cancer whose primary surgery was radical surgery
• The pathological type of primary tumor is adenocarcinoma
• Postoperative local recurrence of colorectal cancer diagnosed by imaging or pathological examination
• Have complete medical records and continuous follow-up records

You may not qualify if:

• Familial hereditary colorectal malignant tumors
• Past history of other malignant tumors
• Recurrence and diffuse peritoneal recurrence occurring within 1 month after surgery

Sponsors & Collaborators

• Cancer Institute and Hospital, Chinese Academy of Medical Sciences: lead

Study Sites (1)

Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

Beijing, Beijing Municipality, 100021, China

RECRUITING

Related Publications (15)

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  PMID: 28657814 BACKGROUND

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  PMID: 12113543 BACKGROUND

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  PMID: 17139459 BACKGROUND

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  PMID: 22219065 BACKGROUND

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  PMID: 27812826 BACKGROUND

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  PMID: 5824273 BACKGROUND

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  PMID: 6689962 BACKGROUND

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  PMID: 22987097 BACKGROUND

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  PMID: 16971718 RESULT

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  PMID: 17008704 RESULT

Study Officials

• Zhaoxu Zheng, M.D.

  Cancer Institute and Hospital, Chinese Academy of Medical Sciences

  STUDY CHAIR

Central Study Contacts

Fei Huang, M.D.

CONTACT

86-010-87787670; frankhuangxm@outlook.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D.

Study Record Dates

• First Submitted: October 28, 2023
• First Posted: November 2, 2023
• Study Start: January 30, 2023
• Primary Completion: January 31, 2025
• Study Completion: December 31, 2025
• Last Updated: November 2, 2023

Record last verified: 2023-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)