The Relationship Between Intraoperative ETCO2 Levels and Postoperative Pain and Nausea-Vomiting

NCT06114277 | Completed

• 1 other identifier: AnkaraEtlikYusufOzguner005
• Study Type: observational
• Target: 109
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of our study is to investigate the relationship between intraoperative ETCO2 levels and postoperative nausea-vomiting and pain scores in patients undergoing robotic laparoscopic radical prostatectomy. The investigators will monitor patients' 24-hour postoperative pain, nausea-vomiting and the consumption of additional analgesic and antiemetic medications.

Conditions

Pain, Postoperative; Nausea, Postoperative; Vomiting, Postoperative

Keywords

End-tidal carbon dioxide; Laparoscopic Robotic Prostatectomy

Outcome Measures

Primary Outcomes (1)

• Postoperative nausea and vomiting (PONV) Score

  Postoperative nausea and vomiting recording in patients. * 0=no PONV: patient reports no nausea and has had no emesis episodes; * 1=mild PONV: patient reports nausea but declines antiemetic treatment; * 2=moderate PONV: patient reports nausea and accepts antiemetic treatment; and * 3=severe PONV: nausea with any emesis episode (retching or vomiting). Higher scores indicate severe postoperative nausea and vomitting.

  0-2-4-8-12-24 hours postoperatively

Secondary Outcomes (1)

• Pain on the Numeric Rating Scale (NRS)

  0-2-4-8-12-24 hours postoperatively

Study Arms (2)

Patients with low ETCO2 levels

Intraoperative ETCO2 values between 26 and 35 in laparoscopic robotic prostatectomy patients were included in this group.

Other: ETCO2 levels

Patients with high ETCO2 levels

Intraoperative ETCO2 values between 36 and 45 in laparoscopic robotic prostatectomy patients were included in this group.

Other: Patients with high ETCO2 levels

Interventions

ETCO2 levels OTHER

Intraoperative ETCO2 values between 26 and 35 in laparoscopic robotic prostatectomy patients were included in group 1.

Also known as: Patients with low ETCO2 levels

Patients with low ETCO2 levels

Patients with high ETCO2 levels OTHER

Intraoperative ETCO2 values between 36 and 45 in laparoscopic robotic prostatectomy patients were included in group 2.

Patients with high ETCO2 levels

Eligibility Criteria

• Age: 18 Years - 80 Years
• Gender Eligibility Details: Robotic prostate surgery is a procedure performed on male patients.
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The aim of our study is to investigate the relationship between intraoperative ETCO2 levels and postoperative nausea, vomiting, and pain scores in patients undergoing robotic laparoscopic radical prostatectomy. We will monitor patients' 24-hour postoperative pain, nausea, vomiting, and the consumption of additional analgesic and antiemetic medications.

You may qualify if:

• Individuals between the ages of 18 and 80.
• Patients with American Society of Anesthesiologists (ASA) scores I, II, or III.
• Patients who have undergone robotic laparoscopic prostatectomy in the operating room.

You may not qualify if:

• Patients under 18 years old or over 80 years old.
• Patients with American Society of Anesthesiologists (ASA) scores IV and above.
• Patients who refuse to participate in the study.
• Patients undergoing emergency surgery.

Sponsors & Collaborators

• Ankara Etlik City Hospital: lead

Study Sites (1)

Ankara Etlik City Hospital

Ankara, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, 06170, Turkey (Türkiye)

Location

Related Publications (3)

• Aceto P, Beretta L, Cariello C, Claroni C, Esposito C, Forastiere EM, Guarracino F, Perucca R, Romagnoli S, Sollazzi L, Cela V, Ercoli A, Scambia G, Vizza E, Ludovico GM, Sacco E, Vespasiani G, Scudeller L, Corcione A; Societa Italiana di Anestesia Analgesia Rianimazione e Terapia Intensiva (SIAARTI), Societa Italiana di Ginecologia e Ostetricia (SIGO), and Societa Italiana di Urologia (SIU). Joint consensus on anesthesia in urologic and gynecologic robotic surgery: specific issues in management from a task force of the SIAARTI, SIGO, and SIU. Minerva Anestesiol. 2019 Aug;85(8):871-885. doi: 10.23736/S0375-9393.19.13360-3. Epub 2019 Mar 29.

  PMID: 30938121 RESULT

• Besir A, Tugcugil E. Comparison of different end-tidal carbon dioxide levels in preventing postoperative nausea and vomiting in gynaecological patients undergoing laparoscopic surgery. J Obstet Gynaecol. 2021 Jul;41(5):755-762. doi: 10.1080/01443615.2020.1789961. Epub 2020 Oct 12.

  PMID: 33045886 RESULT

• Son JS, Oh JY, Ko S. Effects of hypercapnia on postoperative nausea and vomiting after laparoscopic surgery: a double-blind randomized controlled study. Surg Endosc. 2017 Nov;31(11):4576-4582. doi: 10.1007/s00464-017-5519-8. Epub 2017 Apr 7.

  PMID: 28389799 RESULT

MeSH Terms

Conditions

Pain, Postoperative; Postoperative Nausea and Vomiting

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Vomiting

Study Officials

• Yusuf Ozguner

  Ankara Etlik City Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 29, 2023
• First Posted: November 2, 2023
• Study Start: June 10, 2024
• Primary Completion: August 2, 2024
• Study Completion: August 15, 2024
• Last Updated: May 4, 2025

Record last verified: 2025-05

Locations

TU (1)