Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation

NCT06107543 | Completed

• 1 other identifier: DerinceTRH-EAtli-001
• Study Type: observational
• Target: 94
• Locations: 1 country
• Sites: 1

Brief Summary

Direct laryngoscopy and endotracheal intubation procedure stimulate the sympathetic nervous system, causing catecholamine release into the circulation and consequently hemodynamic changes.There are many studies showing that lidocaine is used intravenously to suppress the sympathetic response to laryngoscopy and endotracheal intubation. Nebulized lidocaine is often used to provide upper airway local anesthesia in fiberoptic guided awake intubation. In this study, the researchers aimed to compare the results of using intravenous lidocaine and nebulized lidocaine to suppress the hemodynamic response caused by laryngoscopy and endotracheal intubation retrospectively. Researchers' hypothesis; Nebulized lidocaine administration is more effective than intravenous lidocaine administration in suppressing the hemodynamic response due to laryngoscopy and endotracheal intubation in patients under general anesthesia.

Conditions

Lidocaine

Keywords

Lidocaine; Intubation; General anaesthesia

Outcome Measures

Primary Outcomes (9)

• Heart Rate

  Patients were monitored with a three-lead ECG in the operating room and their heart rates were recorded as beats per minute. (.../min)

  Just before induction of anesthesia

• Heart Rate

  Patients were monitored with a three-lead ECG in the operating room and their heart rates were recorded as beats per minute. (.../min)

  Immediately after induction of anesthesia

• Heart Rate

  Patients were monitored with a three-lead ECG in the operating room and their heart rates were recorded as beats per minute. (.../min)

  5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation

• Blood Pressure

  The patients were monitored in the operating room by wearing a noninvasive blood pressure cuff and measurements were taken at 5-minute intervals. Systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded in mmHg.

  Just before induction of anesthesia

• Blood Pressure

  The patients were monitored in the operating room by wearing a noninvasive blood pressure cuff and measurements were taken at 5-minute intervals. Systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded in mmHg.

  Immediately after induction of anesthesia

• Blood Pressure

  The patients were monitored in the operating room by wearing a noninvasive blood pressure cuff and measurements were taken at 5-minute intervals. Systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded in mmHg.

  5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation

• Oxygen Saturation

  The patients were monitored with a pulse oximetry device in the operating room and their oxygen saturation % (spO2) was recorded.

  Just before induction of anesthesia

• Oxygen Saturation

  The patients were monitored with a pulse oximetry device in the operating room and their oxygen saturation % (spO2) was recorded.

  Immediately after induction of anesthesia

• Oxygen Saturation

  The patients were monitored with a pulse oximetry device in the operating room and their oxygen saturation % (spO2) was recorded.

  5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation

Study Arms (2)

Intravenous lidocaine

Patients who received lidocaine intravenously before induction of anesthesia will be considered in this group.

Drug: Iv Lidocaine

Nebulized lidocaine

Patients who received lidocaine by inhalation with a nebulizer before induction of anesthesia will be considered in this group.

Drug: Nebulized Lidocaine

Interventions

Nebulized Lidocaine DRUG

Before induction of anesthesia, 2% lidocaine + physiological saline was added to a nebulizer and inhaled for 3-5 minutes in the presence of 4-6 liters/minute of oxygen.

Nebulized lidocaine

Iv Lidocaine DRUG

Intravenous %2 lidocaine was administered before induction of anesthesia.

Intravenous lidocaine

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

80 patients over the age of 18 and under the age of 80 who underwent surgery under general anesthesia in the operating room will be included in the study.

You may qualify if:

• Patients over the age of 18 and under the age of 80 who underwent surgery under general anesthesia

You may not qualify if:

• Patients under the age of 18 and over the age of 80
• Patients who are not operated under general anesthesia

Sponsors & Collaborators

• Derince Training and Research Hospital: lead

Study Sites (1)

Derince Training and Research Hospital

Kocaeli, 41900, Turkey (Türkiye)

Location

Related Publications (2)

• Baronia AK, Singh PK, Maheshwari A, Jain VK, Mittal P, Pant KC. Inhaled lidocaine for prevention of hemodynamic changes in laryngoscopy and intubation. J Neurosurg Anesthesiol. 1992 Jul;4(3):154-9. doi: 10.1097/00008506-199207000-00002.

  PMID: 15815458 RESULT

• Sklar BZ, Lurie S, Ezri T, Krichelli D, Savir I, Soroker D. Lidocaine inhalation attenuates the circulatory response to laryngoscopy and endotracheal intubation. J Clin Anesth. 1992 Sep-Oct;4(5):382-5. doi: 10.1016/0952-8180(92)90160-3.

  PMID: 1389192 RESULT

MeSH Terms

Interventions

Lidocaine

Intervention Hierarchy (Ancestors)

Acetanilides; Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Anesthesiology and Reanimation

Study Record Dates

• First Submitted: September 4, 2023
• First Posted: October 30, 2023
• Study Start: December 1, 2023
• Primary Completion: June 1, 2024
• Study Completion: June 22, 2024
• Last Updated: June 25, 2024

Record last verified: 2024-06

Locations

TU (1)