NCT06103565

Brief Summary

The purpose of this pilot feasibility study is to test a pharmacist-facing clinical decision support tool designed to increase adherence to guideline-directed medical therapy and evaluate the tool using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) evaluation framework.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started May 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 23, 2023

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 27, 2023

Completed
1.5 years until next milestone

Study Start

First participant enrolled

May 13, 2025

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 21, 2025

Completed
23 days until next milestone

Study Completion

Last participant's last visit for all outcomes

August 13, 2025

Completed
Last Updated

December 2, 2025

Status Verified

November 1, 2025

Enrollment Period

2 months

First QC Date

October 23, 2023

Last Update Submit

November 24, 2025

Conditions

Keywords

Heart FailureHeart Failure, SystolicQuality of Health CarePharmacistsMedication Adherence

Outcome Measures

Primary Outcomes (1)

  • Reach

    Percentage of alerts in which the pharmacist contacts the patient to discuss the low medication adherence rate

    2-months

Secondary Outcomes (2)

  • Adoption

    2-months

  • Implementation

    After the end of the 2-month intervention period

Study Arms (1)

Active clinical decision support tool for pharmacists

OTHER

In this single arm, pilot feasibility study, pharmacists with be exposed to a clinical decision support tool to facilitate monitoring adherence to GDMT for patients with heart failure with reduced ejection fraction

Other: Clinical Decision Support Tool

Interventions

Clinical decision support tool to enable pharmacists to monitor adherence to guideline-directed medical therapy for patients with heart failure with reduced ejection fraction

Active clinical decision support tool for pharmacists

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Pharmacist at Northwestern Medicine participating in the Medication Adjusted to Target (MAT) Clinic

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Northwestern University Feinberg School of Medicine

Chicago, Illinois, 60611, United States

Location

MeSH Terms

Conditions

Heart FailureHeart Failure, SystolicMedication Adherence

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular DiseasesPatient CompliancePatient Acceptance of Health CareTreatment Adherence and ComplianceHealth BehaviorBehavior

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

October 23, 2023

First Posted

October 27, 2023

Study Start

May 13, 2025

Primary Completion

July 21, 2025

Study Completion

August 13, 2025

Last Updated

December 2, 2025

Record last verified: 2025-11

Data Sharing

IPD Sharing
Will not share

Due to the small number of participants and the inability to fully de-identify the data, IPD will only be share with researchers with an appropriate data use agreement in place.

Locations