Cold Snare Polypectomy Versus Hot Snare Polypectomy for Resection of Small Pedunculated Polyps

NCT06097650 | Completed

• 1 other identifier: 2023-140A-YJ01
• Study Type: interventional
• Target: 196
• Locations: 1 country
• Sites: 1

Brief Summary

Endoscopic resection of pedunculated polyps mainly focuses on how to prevent bleeding, and also needs to pay attention to the convenience of resection and the integrity of resection, which means that different endoscopic resection strategies should be adopted for pedunculated polyps with different stalk sizes. Small pedunculated polyps with heads smaller than 20mm and stalks less than or equal to 5mm are defined as having a relatively small risk of bleeding. Preliminary studies in recent years suggest that the use of cold snare polypectomy for small pedunculated polyps may also be a safe resection strategy. However, for small pedunculated polyps, ASGE and ESGE guidelines currently recommend hot snare polypectomy in the middle and lower pedicles (evidence level medium). Therefore, the provision of high-quality clinical evidence related to cold resection techniques in the resection strategy of small pedunculated polyps may provide a basis for revision of guidelines.

Conditions

Pedunculated Colorectal Polyps; Haemorrhage

Outcome Measures

Primary Outcomes (1)

• delayed hemorrhage

  Any symptoms of gastrointestinal bleeding (e. g. hematochezia) occurred within 30 days after polypectomy and were classified as mild or severe according on the severity of the bleeding

  2 days, 2 weeks and 4 weeks

Secondary Outcomes (1)

• Prevalence of immediate bleeding

  1 Minutes

Other Outcomes (1)

• Immediate perforation rate

  Immediate

Study Arms (2)

cold snare polypectomy

EXPERIMENTAL

cold snare polypectomy for resection of small pedunculated colorectal polyps

Other: cold snare polypectomy

hot snare polypectomy

ACTIVE COMPARATOR

hot snare polypectomy for resection of small pedunculated colorectal polyps

Other: hot snare polypectomy

Interventions

cold snare polypectomy OTHER

Histological analyses suggest that cold snare polypectomy causes less damage to blood vessels in the submucosal layers, which results in a reduced incidence of hemorrhage

cold snare polypectomy

hot snare polypectomy OTHER

According to current clinical guidelines, hot snare polypectomy is the recommended standard technique for the resection of pedunculated colorectal polyps.

hot snare polypectomy

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \. Patients undergoing endoscopic resection of small pedicled polyps in the First Affiliated Hospital of Ningbo University, The Third People's Hospital Health Care Group of Cixi, Ninghai Second Hospital and Renmin Hospital of Yuyao City from October 2023 to August 2026; 2. Patients who voluntarily agreed to participate in this study and signed informed consent.

You may not qualify if:

• \. Persons under 18 years of age 2. Persons unwilling or unable to provide informed consent 3. Treatment or radiotherapy for malignant diseases, severe chronic heart or lung diseases, coronary or cerebrovascular events requiring hospitalization within the last 3 months 4.polyps with endoscopic features suspicious for carcinoma 5. Abdominal symptoms such as severe abdominal pain, abdominal distension, and nausea 6.Patients with inadequate intestinal preparation 7. Patients with lifelong anticoagulant therapy or severe bleeding diseases, patients who have recently taken anticoagulant drugs or antiplatelet drugs (within 1 week) 8.Pregnant or lactating

Sponsors & Collaborators

• Ningbo No. 1 Hospital: lead
• Ninghai Second Hospital: collaborator
• The People's Hospital of Yuyao City: collaborator
• The Third People's Hospital Health Care Group of Cixi: collaborator

Study Sites (1)

the First Affiliated Hospital of Ningbo University

Ningbo, Zhejiang, 315000, China

Location

MeSH Terms

Conditions

Hemorrhage

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 18, 2023
• First Posted: October 24, 2023
• Study Start: October 18, 2023
• Primary Completion: June 15, 2025
• Study Completion: June 15, 2025
• Last Updated: July 24, 2025

Record last verified: 2025-07

Locations

CN (1)