NCT06097260

Brief Summary

A randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of bexotegrast (PLN-74809) for the treatment of idiopathic pulmonary fibrosis (BEACON-IPF).

Trial Health

68
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
320

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Nov 2023

Shorter than P25 for phase_2

Geographic Reach
25 countries

268 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 18, 2023

Completed
6 days until next milestone

First Posted

Study publicly available on registry

October 24, 2023

Completed
23 days until next milestone

Study Start

First participant enrolled

November 16, 2023

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 4, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 4, 2025

Completed
Last Updated

August 1, 2025

Status Verified

July 1, 2025

Enrollment Period

1.4 years

First QC Date

October 18, 2023

Last Update Submit

July 29, 2025

Conditions

Keywords

IPFidiopathic pulmonary fibrosispulmonary fibrosisbexotegrastBeaconBEACON-IPF

Outcome Measures

Primary Outcomes (1)

  • To characterize the effect of bexotegrast versus placebo on the change in forced vital capacity (FVC) in participants with idiopathic pulmonary fibrosis (IPF)

    Change from baseline in absolute FVC (mL) at Week 52

    52 weeks

Secondary Outcomes (9)

  • To characterize the effect of bexotegrast versus placebo over 52 weeks of treatment on disease progression

    Up to 52 weeks

  • Time to disease progression defined as

    Up to 52 weeks

  • Proportion of participants with disease progression defined as

    Up to 52 weeks

  • To characterize the effect of bexotegrast versus placebo on the change in FVC in participants with and without background therapy at baseline with IPF

    52 weeks

  • Change from baseline in Living with Pulmonary Fibrosis (L-PF) Dyspnoea and Cough Domain score

    52 Weeks

  • +4 more secondary outcomes

Study Arms (3)

Placebo

EXPERIMENTAL

Placebo

Drug: Placebo

Bexotegrast (PLN-74809) 160 mg Dose

EXPERIMENTAL

Bexotegrast (PLN-74809) 160 mg Dose - 52 weeks

Drug: PLN-74809

Bexotegrast (PLN-74809) 320 mg Dose

EXPERIMENTAL

Bexotegrast (PLN-74809) 320 mg Dose - 52 weeks

Drug: PLN-74809

Interventions

PLN-74809

Bexotegrast (PLN-74809) 160 mg DoseBexotegrast (PLN-74809) 320 mg Dose

Placebo

Placebo

Eligibility Criteria

Age40 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • ≥ 40 years of age prior to screening
  • IPF diagnosis ≤ 7 years prior to screening
  • FVCpp ≥ 45%
  • Diffusing capacity for carbon monoxide percent predicted (hemoglobin-adjusted) ≥ 30% and \< 90%
  • Current treatment for IPF with background therapy is allowed, if at a stable dose for ≥ 12 weeks prior to screening
  • If not currently receiving treatment for IPF (either treatment naïve or discontinued prior treatment), participant must not have taken background therapy for at least 8 weeks prior to screening

You may not qualify if:

  • Receiving pharmacologic therapy for pulmonary hypertension
  • Self-reported smoking of any kind (not limited to tobacco)
  • History of malignancy within the past 5 years or ongoing malignancy other than basal cell carcinoma, resected noninvasive cutaneous squamous cell carcinoma, or treated cervical carcinoma in situ
  • Hepatic impairment or end-stage liver disease
  • Renal impairment or end-stage kidney disease requiring dialysis
  • Pregnant or lactating female participant
  • Uncontrolled systemic arterial hypertension
  • Receiving any unapproved or investigational agent intended for treatment of fibrosis in IPF
  • Prior administration of bexotegrast
  • Forced expiratory volume in the first second (FEV1)/FVC ratio \<0.7 at screening
  • Clinical evidence of active infection, including, but not limited to bronchitis, pneumonia, or sinusitis that can affect FVC measurement during screening or at randomization
  • Known acute IPF exacerbation, or suspicion by the Investigator of such, 6 months prior to screening

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (268)

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

Location

Arizona Pulmonary Specialists

Phoenix, Arizona, 85012, United States

Location

Dignity Health-St. Josephs Hospital and Medical Center

Phoenix, Arizona, 85013, United States

Location

Banner University Medical Center

Tucson, Arizona, 85724, United States

Location

Cedars Sinai Medical Center

Los Angeles, California, 90048, United States

Location

Newport Native MD, Inc

Newport Beach, California, 92663, United States

Location

Palmtree Clinical Research

Palm Springs, California, 92262, United States

Location

VA Palo Alto Health Care System

Palo Alto, California, 94304, United States

Location

Paradigm Clinical Research Institute Inc - ClinEdge

Redding, California, 96001, United States

Location

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95807, United States

Location

UCSF Medical Center - Pulmonary Practice

San Francisco, California, 94143, United States

Location

Jeffrey S. Sager, MD Medical Corporation

Santa Barbara, California, 93105, United States

Location

Stanford Health Care

Stanford, California, 94305, United States

Location

University of Colorado

Aurora, Colorado, 80048, United States

Location

National Jewish Health Main Campus

Denver, Colorado, 80206, United States

Location

Critical Care, Pulmonary and Sleep Associates

Lakewood, Colorado, 80228, United States

Location

Nuvance Health Medical Practices, Pulmonary & Sleep Specialists

Danbury, Connecticut, 06810, United States

Location

Yale New Haven Hospital - York Street Campus

New Haven, Connecticut, 06510, United States

Location

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States

Location

Malcom Randall VA Medical Center

Gainesville, Florida, 32608, United States

Location

Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States

Location

Clinical Research Specialists, LLC

Kissimmee, Florida, 34746, United States

Location

Clinical Site Partners - Leesburg

Leesburg, Florida, 34738, United States

Location

Central Florida Pulmonary Group PA

Orlando, Florida, 32803, United States

Location

GCP Clinical Research

Tampa, Florida, 33609, United States

Location

Emory Clinic

Atlanta, Georgia, 30322, United States

Location

Augusta University

Augusta, Georgia, 30912, United States

Location

Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States

Location

Loyola University Medical Center

Maywood, Illinois, 60153, United States

Location

IU Health Advanced Heart and Lung Care

Indianapolis, Indiana, 46202, United States

Location

University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Location

Lexington VA Medical Center

Lexington, Kentucky, 40508, United States

Location

Norton Pulmonary Specialists

Louisville, Kentucky, 40202, United States

Location

Tulane Medical Center

New Orleans, Louisiana, 70112, United States

Location

University of Maryland Medical Center

Baltimore, Maryland, 21201, United States

Location

The Johns Hopkins Hospital JHH

Baltimore, Maryland, 21224, United States

Location

Massachusetts General Hospital - Pulmonary Associates

Boston, Massachusetts, 02114, United States

Location

Brigham and Womans Hospital

Boston, Massachusetts, 02115, United States

Location

Beth Israel Deaconess Medical Cente

Boston, Massachusetts, 02215, United States

Location

Infinity Medical Research

North Dartmouth, Massachusetts, 02747, United States

Location

University of Michigan Health System

Ann Arbor, Michigan, 48109, United States

Location

Henry Ford Health System

Detroit, Michigan, 48202, United States

Location

University of Minnesota Medical Center, Fairview

Minneapolis, Minnesota, 55455, United States

Location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location

The Lung Research Center

Chesterfield, Missouri, 63017, United States

Location

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States

Location

Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States

Location

New York Presbyterian Hospital-Columbia University Medical Center

New York, New York, 10032, United States

Location

Weill Cornell Medicine

New York, New York, 10032, United States

Location

Montefiore Medical Center Moses Division Hospital

The Bronx, New York, 10467, United States

Location

Duke University Medical Center

Durham, North Carolina, 27710, United States

Location

PulmonIx, LLC

Greensboro, North Carolina, 27403, United States

Location

Southeastern Research Center

Winston-Salem, North Carolina, 27103, United States

Location

University of Cincinnati

Cincinnati, Ohio, 45267, United States

Location

The Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

Location

OU Health Physicians

Oklahoma City, Oklahoma, 73104, United States

Location

Bend Memorial Clinic/Summit Medical Group - Eastside

Bend, Oregon, 97701, United States

Location

Legacy Good Samaritan Hospital

Portland, Oregon, 97232, United States

Location

Clinical Research Associates Of Central PA , LLC

DuBois, Pennsylvania, 15801, United States

Location

Penn State Health Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033, United States

Location

Perelman Center for Advanced Medicine

Philadelphia, Pennsylvania, 19104, United States

Location

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States

Location

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

Location

Velocity Clinical Research

Greenville, South Carolina, 29615, United States

Location

Lowcountry Lung and Critical Care PA

North Charleston, South Carolina, 29406, United States

Location

Clinical Trials Center of Middle Tennessee

Franklin, Tennessee, 37067, United States

Location

Statcare Pulmonary Consultants - Knoxville

Knoxville, Tennessee, 37909, United States

Location

University of Tennessee Medical Center

Knoxville, Tennessee, 37920, United States

Location

Vanderbilt University Medical Center

Nashville, Tennessee, 37204, United States

Location

Baylor Scott and White Health - Advanced Lung Disease Specialists

Dallas, Texas, 75246, United States

Location

El Paso Pulmonary Association

El Paso, Texas, 79902, United States

Location

Baylor College of Medicine

Houston, Texas, 77030, United States

Location

Research Centers of America

McKinney, Texas, 75071, United States

Location

Renovatio Clinical Research

The Woodlands, Texas, 77380, United States

Location

Topline Clinical Research

Waxahachie, Texas, 75165, United States

Location

University of Utah

Salt Lake City, Utah, 84108, United States

Location

University of Vermont Medical Center

Burlington, Vermont, 05401, United States

Location

INOVA Fairfax Medical Campus

Falls Church, Virginia, 22042, United States

Location

Western Washington Medical Group

Everett, Washington, 98208, United States

Location

Centro de Investigaciones Medicas Mar del Plata

Mar del Plata, Buenos Aires, 7600, Argentina

Location

Instituto Ave Pulmo

Mar del Plata, Buenos Aires, B7600DCK, Argentina

Location

Clinica Privada Independencia

Munro, Buenos Aires, B1605FRE, Argentina

Location

Centro Respiratorio Quilmes

Quilmes, Buenos Aires, B1878FNR, Argentina

Location

CEMER - Centro Medico de Enfermedades Respiratorias

Vicente López, Buenos Aires, 1602, Argentina

Location

Centro de Investigacion Clinica-CEDIC

Buenos Aires, Ciudad Autonoma Buenos Aires, 1060, Argentina

Location

Centro Médico Dra de Salvo

Buenos Aires, Ciudad Autónoma de BuenosAires, C1426ABP, Argentina

Location

Instituto Medico Fundacion Grupo Colaborativo Rosario Investigacion y Prevencion Medica

Rosario, Santa Fe Province, 2000, Argentina

Location

Instituto Médico de la Fundación Estudios Clínicos

Rosario, Santa Fe Province, S2000DEJ, Argentina

Location

Sanatorio Parque de Rosario

Rosario, Santa Fe Province, S2000DSV, Argentina

Location

Centro Integral de Medicina Respiratoria (CIMER)

San Miguel de Tucumán, Tucumán Province, T4000CBC, Argentina

Location

Consultorios Médicos Organización de Buen Ayre SRL

Buenos Aires, C1425FVH, Argentina

Location

Hospital Britanico de Buenos Aires

Ciudad Autonoma Buenos Aires, 1280, Argentina

Location

Instituto de Medicina Respiratoria

Córdoba, X5003DCE, Argentina

Location

Fundacion Scherbovsky

Mendoza, M5500AXR, Argentina

Location

INSARES

Mendoza, M5500CCG, Argentina

Location

Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia

Location

Lung Research Qld

Chermside, Queensland, 4032, Australia

Location

Respiratory Clinical Trials

Kent Town, South Australia, 5067, Australia

Location

The Queen Elizabeth Hospital

Woodville South, South Australia, 5011, Australia

Location

Box Hill Hospital

Box Hill, Victoria, 3128, Australia

Location

Monash Medical Centre

Clayton, Victoria, 3168, Australia

Location

Austin Health

Heidelberg, Victoria, 3084, Australia

Location

The Alfred Hospital

Melbourne, Victoria, 3004, Australia

Location

Fiona Stanley Hospital

Murdoch, Western Australia, 6050, Australia

Location

TrialsWest

Spearwood, Western Australia, 6163, Australia

Location

Institute for Respiratory Health - Midland

Midland, 6056, Australia

Location

AZ Delta

Roeselare, West-Vlaanderen, 8800, Belgium

Location

UZ Leuvan

Leuven, 3000, Belgium

Location

Hospital Cardio Pulmonar

Salvador, Estado de Bahia, 40170310, Brazil

Location

Santa Casa de Misericordia de Belo Horizonte

Belo Horizonte, Minas Gerais, 30150-221, Brazil

Location

Instituto Mederi de Pesquisa e Saude

Passo Fundo, Rio Grande do Sul, 99010-120, Brazil

Location

Irmandade da Santa Casa de Misericórdia de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil

Location

Hospital Ernesto Dornelles

Porto Alegre, Rio Grande do Sul, 90160-093, Brazil

Location

Hospital Nossa Senhora da Conceicao

Porto Alegre, Rio Grande do Sul, 91010-006, Brazil

Location

Hospital de Clinicas de Porto Alegre HCPA - PPDS

Porto Alegre, 90410-001, Brazil

Location

Hospital São Lucas da PUCRS

Porto Alegre, 90610-000, Brazil

Location

Kelowna Respirology and Allergy Research

Kelowna, British Columbia, V1Y 3H5, Canada

Location

Pacific Lung Research Center

Vancouver, British Columbia, V6Z 1Y6, Canada

Location

Dynamic Drug Advancement

Ajax, Ontario, L1S 2J5, Canada

Location

CIC Joliette

Saint-Charles-Borromée, Quebec, J6E 2B4, Canada

Location

Centre d'investigation Clinique Mauricie

Trois-Rivières, Quebec, G8T 7A1, Canada

Location

CENRESIN

Quillota, 2260734, Chile

Location

Av. Providencia 1208 oficina 209

Santiago, 7500571, Chile

Location

CIMER - Centro de Investigaciones Medicas Respiratorias

Santiago, 7500657, Chile

Location

CEC SpA

Santiago, 7750495, Chile

Location

Biocinetic

Santiago, 8330336, Chile

Location

Centro de Investigacion del Maule

Talca, 3481349, Chile

Location

The Second Hospital of Anhui Medical University

Hefei, Anhui, 230061, China

Location

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510163, China

Location

Nanfang Hospital of Southern Medical University

Guangzhou, Guangdong, 510515, China

Location

The 3rd Hospital of Hebei Medical University

Shijiazhuang, Hebei, 50051, China

Location

Henan Provincial Chest Hospital

Zhengzhou, Henan, 450000, China

Location

Henan Provincial People's Hospital

Zhengzhou, Henan, 450003, China

Location

Yichang Central People's Hospital

Yichang, Hubei, 443000, China

Location

The second Xiangya Hospital of Central South University

Changsha, Hunan, 410008, China

Location

Wuxi People's Hospital

Wuxi, Jiangsu, 214023, China

Location

The Affiliated Hospital of Xuzhou Medical College

Xuzhou, Jiangsu, 221006, China

Location

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330209, China

Location

Shengjing Hospital of China Medical University

Shenyang, Liaoning, 110004, China

Location

Qilu Hospital of Shandong University

Jinan, Shandong, 250012, China

Location

West China Hospital, Sichuan University

Chengdu, Sichuan, 610041, China

Location

Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital

Chengdu, Sichuan, 610072, China

Location

Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, 300052, China

Location

Hangzhou First People's Hospital

Hangzhou, Zhejiang, 310006, China

Location

Fakultni Nemocnice Olomouc

Olomouc, Olomoucký kraj, 779 00, Czechia

Location

Fakultni nemocnice Brno

Brno, South Moravian, 625 00, Czechia

Location

Fakultni Thomayerova Nemocnice

Prague, 140 00, Czechia

Location

Odense Universitetshospital

Odense, Region Syddanmark, 5000, Denmark

Location

Aarhus Universitetshospital

Aarhus, 8200, Denmark

Location

Aarhus Universitetshospital

Aarhus, Denmark

Location

Gentofte Hospital

Hellerup, 2900, Denmark

Location

Odense Universitetshospital

Odense, Denmark

Location

Hôpital Pontchaillou

Rennes, Ille-et-Vilaine, 35000, France

Location

Institut Coeur Poumon - CHU de Lille

Lille, Nord, 59037, France

Location

Hôpital Avicenne

Bobigny, Seine Saint Denis, 93000, France

Location

CHU de Bordeaux- Hopital du Haut Lévêque

Bordeaux, France

Location

CHU Lyon - Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel

Lyon, France

Location

Hôpital Nord - CHU Marseille

Marseille, France

Location

CHU Arnaud de Villeneuve

Montpellier, France

Location

CHU Nice - Hôpital Pasteur

Nice, France

Location

Hopital Pasteur CHU Nice

Nice, France

Location

Hospital Bretonneau

Paris, France

Location

Hôpital Bichat - Claude Bernard

Paris, France

Location

Hopital Haut-Leveque Pharmacie

Pessac, France

Location

CHU Reims - Hôpital Maison Blanche

Reims, France

Location

Hopital Larrey

Toulouse, France

Location

LMU Klinikum der Universität München - Campus Großhadern

München, Bavaria, 81377, Germany

Location

Medizinische Hochschule Hannover

Hanover, Lower Saxony, 30625, Germany

Location

Kliniken der Stadt Koln

Cologne, North Rhine-Westphalia, 51109, Germany

Location

Ruhrlandklinik

Essen, North Rhine-Westphalia, 45239, Germany

Location

Universitätsklinikum Schleswig-Holstein, Campus Kiel

Kiel, Schleswig-Holstein, 24105, Germany

Location

Evangelische Lungenklinik Berlin

Berlin, 13125, Germany

Location

Fachkrankenhaus Coswig GmbH

Coswig, 01640, Germany

Location

IKF Pneumologie GmbH &amp; Co. KG

Frankfurt, Germany

Location

Universitaetsklinikum des Saarlandes

Homburg, Germany

Location

Universitaetsklinikum Leipzig AoeR

Leipzig, Germany

Location

University General Hospital of Patras

Pátrai, Achaïa, 265 04, Greece

Location

Sotiria Thoracic Diseases Hospital of Athens

Athens, Attica, 115 27, Greece

Location

University General Hospital of Alexandroupolis

Alexandroupoli, Evros, 681 00, Greece

Location

University General Hospital of Heraklion

Heraklion, 71110, Greece

Location

Unity Hospital ICU and Trauma

Surat, Gujarat, 395010, India

Location

ESIC Medical College and Hospital

Faridabad, Haryana, 121001, India

Location

K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre

Belagavi, Karnataka, 590010, India

Location

BHS Lakeview Hospital

Belagavi, Karnataka, 590016, India

Location

Bhatia Hospital

Mumbai, Maharashtra, 400007, India

Location

Siddhi Hospital

Nashik, Maharashtra, 422007, India

Location

J.L.N., Medical College and Attached Hospitals

Ajmer, Rajasthan, 305001, India

Location

Asthma Bhavan

Jaipur, Rajasthan, 302023, India

Location

Midland Healthcare & Research Center

Lucknow, Uttar Pradesh, 226006, India

Location

Calcutta Medical Research Institute

Kolkata, West Bengal, 700027, India

Location

B. P. Poddar Hospital and Medical Research Limited

Kolkata, West Bengal, 700053, India

Location

Kaplan Medical Center

Rehovot, Central District, 76100, Israel

Location

Shaare Zedek Medical Center

Jerusalem, Jerusalem, 91031, Israel

Location

Barzilai Medical Center

Ashkelon, Southern District, 7830604, Israel

Location

Tel Aviv Sourasky Medical Center

Ashkelon, Tel Aviv, 78278, Israel

Location

Sheba Medical Center

Ramat Gan, Tel Aviv, 52394, Israel

Location

Soroka University Medical Center

Beersheba, 84001, Israel

Location

Lady Davis Carmel Medical Center

Haifa, 34362, Israel

Location

Rambam Medical Center

Haifa, 34980, Israel

Location

Meir Medical Center

Kfar Saba, 4428164, Israel

Location

Rabin Medical Center

Petah Tikva, 49100, Israel

Location

Ospedale San Giuseppe Multimedica SpA

Milan, Milano, 20123, Italy

Location

Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo

Alessandria, 15121, Italy

Location

ASST Papa Giovanni XXIII - Azienda Ospedaliera Papa Giovanni XXIII

Bergamo, 24127, Italy

Location

Azienda Ospedaliera Universitaria Careggi

Florence, 50134, Italy

Location

Azienda Ospedaliero-Universitaria Ospedali Riuniti di Foggia

Foggia, 71122, Italy

Location

NHO Kyushu Medical Center

Fukuoka, Fukuoka, 810-0066, Japan

Location

Fukuoka University Hospital

Fukuoka, Fukuoka, 814-0180, Japan

Location

Aso Co.,Ltd Iizuka Hospital

Iizuka-shi, Fukuoka, 820-8505, Japan

Location

Hospital of the University of Occupational and Environmental Health

Kitakyushu-shi, Fukuoka, 807-8556, Japan

Location

Fukushima Medical University Hospital

Fukushima, Fukushima, 960-1295, Japan

Location

Hiroshima Prefectural Hospital

Hiroshima, Hiroshima, 732-0827, Japan

Location

Sapporo Medical University Hospital

Sapporo, Hokkaido, 060-0001, Japan

Location

Kobe City Hospital Organization

Kobe, Hyōgo, 650-0047, Japan

Location

Center General Hospital

Kobe, Hyōgo, 6500047, Japan

Location

NHO Ibarakihigashi National Hospital

Naka-gun, Ibaraki, 319-1113, Japan

Location

Tokushima University Hospital

Kawasaki-shi, Kanagawa, 216-8511, Japan

Location

Kanagawa Cardiovascular and Respiratory Center

Yokohama, Kanagawa, 236-0051, Japan

Location

Kumamoto University Hospital

Kumamoto, Kumamoto, 860-8556, Japan

Location

Okayama University Hospital

Okayama, Okayama-ken, 700-8558, Japan

Location

NHO Kinki-Chuo Chest Medical Center

Osaka, Osaka, 591-8555, Japan

Location

Saitama Prefectural Cardiovascular and Respiratory Center

Kumagaya-shi, Saitama, 360-0197, Japan

Location

Saitama Red Cross Hospital

Saitama-shi, Saitama, 330-8553, Japan

Location

Shimane University Hospital

Izumo-shi, Shimane, 693-8501, Japan

Location

Hamamatsu University School of Medicine, University Hospital

Hamamatsu, Shizuoka, 431-3192, Japan

Location

Institute of Science Tokyo Hospital

Bunkyō City, Tokyo-To, 113-8519, Japan

Location

Nippon Medical School Hospital

Bunkyō City, Tokyo-To, 113-8603, Japan

Location

NHO Okinawa National Hospital

Hachioji-shi, Tokyo-To, 192-0081, Japan

Location

Juntendo University Hospital

Minatoku, Tokyo-To, 105-0023, Japan

Location

VU Medisch Centrum

Amsterdam, North Holland, 1081 HV, Netherlands

Location

St. Antonius Ziekenhuis

Nieuwegein, Utrecht, Netherlands

Location

Christchurch Hospital

Christchurch, Canterbury, 8013, New Zealand

Location

Greenlane Clinical Centre

Auckland, North Island, 1051, New Zealand

Location

Dunedin Hospital

Dunedin, Otago, 9016, New Zealand

Location

Waikato Hospital

Hamilton, Waikato Region, 3204, New Zealand

Location

Twoja Przychodnia NCM

Nowa Sól, Lubusz Voivodeship, 67-100, Poland

Location

Vitamed Galaj i Cichomski sp.j.

Bydgoszcz, Poland

Location

Uniwersyteckie Centrum Kliniczne

Gdansk, 80-952, Poland

Location

SP ZOZ Szpital Uniwersytecki w Krakowie

Krakow, 30-688, Poland

Location

Hospital de Braga

Braga, 4710-243, Portugal

Location

Centro Hospitalar de Lisboa Central, E.P.E - Hospital de Santa Marta

Lisbon, 1169-024, Portugal

Location

Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E.

Vila Nova de Gaia, 4434-502, Portugal

Location

Inje University Busan Paik Hospital

Pusan, Gyeongsangnam-do, 50834, South Korea

Location

Korea University Anam Hospital

Seoul, Seoul Teugbyeolsi, 02841, South Korea

Location

Hanyang University Medical Center

Seoul, Seoul Teugbyeolsi, 04763, South Korea

Location

Inje University Haeundae Paik Hospital

Busan, 48108, South Korea

Location

Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea

Location

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, 06591, South Korea

Location

Hospital Universitario Puerta de Hierro - Majadahonda

Majadahonda, Madrid, 28222, Spain

Location

Hospital Universitari de Bellvitge

Barcelona, 08907, Spain

Location

Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Spain

Location

Hospital Clinico Universitario Virgen de la Victoria

Málaga, Spain

Location

CHUS - H. Clinico U. de Santiago

Santiago de Compostela, 15706, Spain

Location

Kaohsiung Medical University - Chung-Ho Memorial Hospital

Kaohsiung City, 807, Taiwan

Location

China Medical University Hospital

Taichung, 40447, Taiwan

Location

Taichung Veterans General Hospital

Taichung, Taiwan

Location

National Taiwan University Hospital

Taipei, 10002, Taiwan

Location

Taipei Veterans General Hospital

Taipei, 11217, Taiwan

Location

Far Eastern Memorial Hospital

Taipei, 220, Taiwan

Location

Royal Papworth Hospital

Cambridge, Cambridgeshire, CB2 0AY, United Kingdom

Location

Peterborough City Hospital

Peterborough, Cambridgeshire, PE3 9GZ, United Kingdom

Location

Altnagelvin Area Hospital

Londonderry, Derry, BT47 6SB, United Kingdom

Location

Southampton General Hospital

Southampton, Hampshire, SO16 6YD, United Kingdom

Location

Castle Hill Hospital

Cottingham, North Humberside, HU16 5JQ, United Kingdom

Location

Churchill Hospital

Oxford, Oxfordshire, OX3 7LE, United Kingdom

Location

Pinderfields General Hospital

Wakefield, West Yorkshire, WF1 4DG, United Kingdom

Location

Birmingham Heartlands Hospital

Birmingham, B9 5SS, United Kingdom

Location

Royal Brompton Hospital

London, SW3 6NP, United Kingdom

Location

Related Links

MeSH Terms

Conditions

Idiopathic Pulmonary FibrosisPulmonary Fibrosis

Condition Hierarchy (Ancestors)

Lung Diseases, InterstitialLung DiseasesRespiratory Tract DiseasesFibrosisPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Pliant Therapeutics Medical Monitor

    Pliant Therapeutics, Inc.

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 18, 2023

First Posted

October 24, 2023

Study Start

November 16, 2023

Primary Completion

April 4, 2025

Study Completion

April 4, 2025

Last Updated

August 1, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will not share

Locations