Upper Endoscopy in Ulcerative Colitis Patients in Assiut University

NCT06092593 | Unknown

• 1 other identifier: Upper endoscopy UC
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

Aim of study: Primary Outcomes: Patients with ulcerative colitis-associated upper gas- trointestinal inflammation may require specific treat- ment for the gastroduodenal lesions. Hence, recogni- tion and detection of the upper gastrointestinal lesions are important. Here we describe 2 cases of ulcerative colitis and summarize the results of our investigation of the prevalence of upper gastrointestinal involvement detected by esophagogastroduodenoscopy. We also analyzed the macroscopic and microscopic features of the upper gastrointestinal lesions Secondary Outcomes: correct and timely treatment of upprt GIT lesions in UC .

Conditions

Upper Gastrointestinal Disorder

Outcome Measures

Primary Outcomes (1)

• Evaluation of upper gastrointestinal tract lesions in ulcerative colitis patients

  The relationship between ulcerative colitis patients and upper gastrointestinal tract lesions

  Baseline

Interventions

Upper endoscopy DEVICE

Evaluation of upper gastrointestinal tract lesions in ulcerative colitis patients

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A cross sectionaql study will be conducted in Assuit University hospital .Adult patients diagnosed as UC by clinical date , laboratory ,colonscopy and histopathological examination will undergo : full medical history taking : age, gender, time since the ulcerative colitis diagnosis, History of surgery for ulcerative colitis, medications , history of any upper GIT symptoms nausea , vomiting , epigastric pain , heart burn , dysphagia and hematemsis or melena . complete physical examination , with focus on pulse, blood pressure, body temperature and signs of extra intestinal involvement. Esophagogastro-duodenoscopy Histopathological examination of biopsies taken from any lesions

You may qualify if:

• Patients' age is 18 years or above.
• Patient who are diagnosed with UC..
• Patient who are fit to undergo upper endoscopy .

You may not qualify if:

• Pediatric patients.
• patient refuse to participate at this study
• patient with known upper GIT disorder .

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Sun Y, Zhang Z, Zheng CQ, Sang LX. Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review. World J Gastroenterol. 2021 Jun 14;27(22):2963-2978. doi: 10.3748/wjg.v27.i22.2963.

  PMID: 34168401 BACKGROUND

• Kato R, Iwamuro M, Hiraoka S, Takashima S, Inokuchi T, Takahara M, Kondo Y, Tanaka T, Okada H. Evaluation of the Upper Gastrointestinal Tract in Ulcerative Colitis Patients. Acta Med Okayama. 2018 Apr;72(2):105-113. doi: 10.18926/AMO/55850.

  PMID: 29674758 BACKGROUND

• Queliza K, Ihekweazu FD, Schady D, Jensen C, Kellermayer R. Granulomatous Upper Gastrointestinal Inflammation in Pediatric Ulcerative Colitis. J Pediatr Gastroenterol Nutr. 2018 Apr;66(4):620-623. doi: 10.1097/MPG.0000000000001771.

  PMID: 28991840 BACKGROUND

MeSH Terms

Conditions

Gastrointestinal Diseases

Interventions

Gastroscopy

Condition Hierarchy (Ancestors)

Digestive System Diseases

Intervention Hierarchy (Ancestors)

Endoscopy, Gastrointestinal; Endoscopy, Digestive System; Diagnostic Techniques, Digestive System; Diagnostic Techniques and Procedures; Diagnosis; Endoscopy; Diagnostic Techniques, Surgical; Digestive System Surgical Procedures; Surgical Procedures, Operative; Minimally Invasive Surgical Procedures

Central Study Contacts

Gamal A Gaber, Master

CONTACT

01126526545; gmalabnaser96@gmail.com

Muhammad Abass el masry, Professor

CONTACT

+20 121 240 1707; masaeed2@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: September 28, 2023
• First Posted: October 23, 2023
• Study Start: January 1, 2024
• Primary Completion: January 1, 2025
• Study Completion: October 1, 2025
• Last Updated: November 8, 2023

Record last verified: 2023-10