Role of Positron Emission Tomography in Detecting Primary Tumor in Cases of Metastases of Unknown Origin

NCT06086652 | Unknown

• 1 other identifier: Soh-Med-23-09-2PD
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

In most cases of malignancies, the site of origin of the cancer is clear at presentation or identified soon after. However, Metastatic cancer of unknown primary site (MUO) accounts for 3-5% of all malignant neoplasms, and it is defined as metastatic cancer from an unknown primary site, for which no original site can be detected even after performing all possible tests. Most common metastatic sites include the liver, lymph nodes, lungs, and bones. 18F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) allows whole-body tumor detection and has proven to be useful in patients with metastasis of unknown primary tumor.

Conditions

Metastasis of Unknown Origin

Outcome Measures

Primary Outcomes (1)

• primary tumor for metastasis of unknown origin

  primary tumor for metastasis of unknown origin

  one month

Interventions

PET/CT DIAGNOSTIC_TEST

detection of possible primary tumor

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Age \> 18 years Patients with metastatic tumor. Primary site was not detected with other radiological examinations Both male and female.

You may qualify if:

• Age \> 18 years Patients with metastatic tumor. Primary site was not detected with other radiological examinations Both male and female.

You may not qualify if:

• Patients with known primary tumor Pregnancy. Age \< 18 years.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university Hospital

Sohag, Egypt

RECRUITING

Related Publications (2)

• van der Strate I, Kazemzadeh F, Nagtegaal ID, Robbrecht D, van de Wouw A, Padilla CS, Duijts S, Esteller M, Greco FA, Pavlidis N, Qaseem A, Snaebjornsson P, van Zanten SV, Loef C. International consensus on the initial diagnostic workup of cancer of unknown primary. Crit Rev Oncol Hematol. 2023 Jan;181:103868. doi: 10.1016/j.critrevonc.2022.103868. Epub 2022 Nov 23.

  PMID: 36435296 BACKGROUND

• Kwee TC, Kwee RM. Combined FDG-PET/CT for the detection of unknown primary tumors: systematic review and meta-analysis. Eur Radiol. 2009 Mar;19(3):731-44. doi: 10.1007/s00330-008-1194-4. Epub 2008 Oct 17.

  PMID: 18925401 BACKGROUND

MeSH Terms

Interventions

Positron Emission Tomography Computed Tomography

Intervention Hierarchy (Ancestors)

Positron-Emission Tomography; Tomography, Emission-Computed; Image Interpretation, Computer-Assisted; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Tomography, X-Ray Computed; Multimodal Imaging; Radiographic Image Enhancement; Image Enhancement; Photography; Radiography; Tomography, X-Ray; Radionuclide Imaging; Tomography; Diagnostic Techniques, Radioisotope

Central Study Contacts

Doaa I Mohamed, lecturer

CONTACT

01007779485; doaaibrahim@med.soh.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer of nuclear medicine, faculty of medicine, Sohag university

Study Record Dates

• First Submitted: October 11, 2023
• First Posted: October 17, 2023
• Study Start: September 15, 2023
• Primary Completion: December 1, 2023
• Study Completion: December 1, 2023
• Last Updated: October 17, 2023

Record last verified: 2023-10

Locations

EG (1)