Effect of Lifestyle on Caries and Apical Periodontitis

NCT06072742 | Completed

• 1 other identifier: LS002
• Study Type: observational
• Target: 149
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to link lifestyle factors (Mediterranean diet adherence, stress, sleep quality, physical activity) to caries and apical periodontitis in 149 university-based individuals. Data included clinical and radiographic assessments and lifestyle questionnaires. Statistical tests and logistic regression were employed to analyze the relationships between these factors and oral health conditions.

Conditions

Apical Periodontitis; Caries; Lifestyle; Inflammation; Endodontics

Keywords

Apical periodontitis; caries; inflammation; Endodontics; lifestyle

Outcome Measures

Primary Outcomes (3)

• Presence of Apical Periodontitis

  The periapical status was investigated by palpation, percussion, thermal cold testing, and panoramic radiographs. Afterward, teeth that exhibited deep carious lesions, deep restorations, no response to pulp testing, or painful response to biting and/or percussion or palpation were suspected of AP. Those teeth underwent further periapical radiograph using the long cone paralleling technique with a film holder. AP cases were diagnosed based on the identification of at least one tooth with periapical radiolucency outpacing twice the width of the periodontal ligament space and having PAI \> 2.

  The time frame for this observational study is defined by the initial assessment conducted at baseline. No follow-up measurements are scheduled, and the study aims to explore associations and characteristics at a single time point

• Periapical index (PAI)

  Periapical health was assessed radiographically using the PAI score that was determined through visual inspection of the periapical area, assigning a numerical value based on the extent and severity of inflammation. Scores ranged from 0 to 5

  The time frame for this observational study is defined by the initial assessment conducted at baseline. No follow-up measurements are scheduled, and the study aims to explore associations and characteristics at a single time point

• Decayed, missing, filled teeth (DMFT) index

  The DMFT index is calculated by summing the scores for decayed (D), missing (M), and filled (F) teeth for an individual or a group of individuals

  The time frame for this observational study is defined by the initial assessment conducted at baseline. No follow-up measurements are scheduled, and the study aims to explore associations and characteristics at a single time point

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All consecutive patients attending the Unit of Endodontics at the University of Siena were screened between September 2020 and August 2021. Patients were eligible based on the inclusion criteria. Individuals were included in the study after they read and signed the written informed consent, in accordance with the Declaration of Helsinki.

You may qualify if:

• age between 18 and 70
• Good general health status;
• Ability and willingness to give written consent;
• Presence of at least 6 teeth.

You may not qualify if:

• Age \<18 years;
• Pregnancy or lactation;
• administration of antibiotics within the last 6 months;
• Inability and unwillingness to give written consent

Sponsors & Collaborators

• University of Siena: lead

Study Sites (1)

Azienda Ospedaliera Universitaria Senese

Siena, 53100, Italy

Location

MeSH Terms

Conditions

Periapical Periodontitis; Inflammation

Condition Hierarchy (Ancestors)

Periapical Diseases; Jaw Diseases; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Periodontitis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Simone Grandini, DDS

  University of Siena

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 2, 2023
• First Posted: October 10, 2023
• Study Start: September 20, 2020
• Primary Completion: August 20, 2021
• Study Completion: August 20, 2021
• Last Updated: December 1, 2023

Record last verified: 2023-11

Locations

IT (1)