Association Between Apical Periodontitis and Psoriasis Vulgaris

NCT06436339 | Completed

• 1 other identifier: PSY003
• Study Type: observational
• Target: 152
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the present cross-sectional study is to assess the presence of AP and caries in psoriasis vulgaris individuals and to examine whether these medications influence these oral conditions. Therefore, 154 patients diagnosed with psoriasis were included in the study and subjected to oral examination to assess for presence of periapical lesions and caries experience.

Conditions

Apical Periodontitis

Keywords

Psoriasis vulgaris

Outcome Measures

Primary Outcomes (3)

• Apical Periodontitis

  The periapical status was investigated by palpation, percussion, thermal cold testing, and panoramic radiographs. Afterward, teeth that exhibited deep carious lesions, deep restorations, no response to pulp testing, or painful response to biting and/or percussion or palpation were suspected of AP. Those teeth underwent further periapical radiograph using the long cone paralleling technique with a film holder. AP cases were diagnosed based on the identification of at least one tooth with periapical radiolucency outpacing twice the width of the periodontal ligament space and having PAI \> 2.

  The time frame for this observational study is defined by the initial assessment conducted at baseline. No follow-up measurements are scheduled, and the study aims to explore associations and characteristics at a single time point

• Periapical Index Score (PAI)

  Periapical health was assessed radiographically using the PAI score that was determined through visual inspection of the periapical area, assigning a numerical value based on the extent and severity of inflammation. Scores ranged from 0 to 5

  The time frame for this observational study is defined by the initial assessment conducted at baseline. No follow-up measurements are scheduled, and the study aims to explore associations and characteristics at a single time point

• The DMFT index is calculated by summing the scores for decayed (D), missing (M), and filled (F) teeth for an individual or a group of individuals

  The DMFT index is calculated by summing the scores for decayed (D), missing (M), and filled (F) teeth for an individual or a group of individuals

  The time frame for this observational study is defined by the initial assessment conducted at baseline. No follow-up measurements are scheduled, and the study aims to explore associations and characteristics at a single time point

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants were recruited from a specialty outpatient dermatology clinic (Unit of Dermatology, Azienda Ospedaliero-Universitaria Senese, Siena, Italy) from February 2022 to November 2023. Patients were eligible based on the inclusion criteria. Individuals were included in the study after they read and signed the written informed consent, in accordance with the Declaration of Helsinki.

You may qualify if:

• Age between 18 and 70
• Ability and willingness to give written consent;
• Presence of at least 6 teeth.
• Diagnosis of Psoriasis Vulgaris
• Other systemic diseases apart from psoriasis

You may not qualify if:

• diagnosis of periodontitis
• inability or unwillingness to give informed consent;
• periodontal treatment within the previous 6 months;
• ongoing immunosuppressive treatments or antibiotic therapy for other systemic diseases;
• pregnant or on lactation;
• additional comorbidities
• non endodontic lesions in maxilla/mandible;
• AP diagnosed on teeth with inadequate endodontic treatments and coronal restorations

Sponsors & Collaborators

• University of Siena: lead

Study Sites (1)

Azienda Ospedaliera Universitaria Senese

Siena, Tuscany, 53100, Italy

Location

MeSH Terms

Conditions

Periapical Periodontitis

Condition Hierarchy (Ancestors)

Periapical Diseases; Jaw Diseases; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Periodontitis

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Department of Endodontics, Periodontology, Restorative and Paediatric Dentistry

Study Record Dates

• First Submitted: May 23, 2024
• First Posted: May 31, 2024
• Study Start: February 2, 2022
• Primary Completion: November 25, 2023
• Study Completion: November 25, 2023
• Last Updated: June 3, 2024

Record last verified: 2024-05

Locations

IT (1)