Maximal Rate of Force Development of Ankle Muscles and Functional Ability in Patients With Knee Osteoarthritis

NCT06063889 | Completed

• 1 other identifier: 012/90002023
• Study Type: observational
• Target: 126
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a detailed assessment of the maximal rate of force development of ankle muscles and its association with functional ability in patients with knee osteoarthritis (OA).

Conditions

Knee Osteoarthritis; Knee Arthritis

Outcome Measures

Primary Outcomes (5)

• Knee Osteoarthritis Outcome Score (KOOS)

  The KOOS is a questionnaire that assesses five aspects of knee injury and osteoarthritis: pain, symptoms, ADL function, sport and recreation function, and quality of life. Scores are transformed to a 0-100 scale, with zero representing extreme knee problems and 100 representing no knee problems. Higher scores indicate better function and less pain.

  Baseline

• Forward Step Down Test (FSDT)

  This functional ability test requires participants to perform as many repetitions as possible in 30 seconds of a specific movement. The number of valid repetitions performed in this duration is recorded.

  Baseline

• Single Leg Hop Test (SLHT)

  n this test, participants hop forward as far as possible on one leg, and the distance hopped is recorded.

  Baseline

• Isokinetic Testing Procedures

  This procedure involves conducting tests of three (60°/s) or five (120°/s) maximal nonconsecutive efforts with specific rest intervals. Each subject is instructed to exert maximal effort throughout the whole range of motion.

  Baseline

• Rate of Force Development (RFD)

  The RFD is a measure of the speed at which the force of a muscle contraction develops. It is typically measured during isometric contractions and provides information about the muscle's explosive strength capacity.

  Baseline

Study Arms (2)

Knee OA Patients

This group consists of patients who have been diagnosed with knee osteoarthritis. They will be subjected to a series of tests to assess the maximal rate of force development of ankle muscles and their functional abilities.

Diagnostic Test: Maximal Rate of Force Development Test for Ankle Muscles

Healthy Control

This group will include healthy individuals without knee osteoarthritis. They will undergo the same series of tests to serve as a control group, enabling the comparison of results with the Knee OA Patients group.

Diagnostic Test: Maximal Rate of Force Development Test for Ankle Muscles

Interventions

Maximal Rate of Force Development Test for Ankle Muscles DIAGNOSTIC_TEST

This test is designed to measure the maximal rate of force development in the ankle muscles, specifically the plantar flexors. It aims to assess the relationship between the strength of these muscles and the functional ability in patients with knee osteoarthritis. The results from this test will help to understand how lower limb muscle strength influences the symptoms and progression of knee osteoarthritis.

Healthy Control; Knee OA Patients

Eligibility Criteria

• Age: 30 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients suffering from knee osteoarthritis.

You may qualify if:

• Group 1 (Knee OA group)
• Patients diagnosed with knee osteoarthritis according to Performance of the 2018 classification criteria for early stage knee OA was tested using data from the Osteoarthritis Initiative (OAI (Leung et al.,2020).
• Grade 2-3 KOA cases according to Kelgren-Lawrance classification
• Having knee pain for at least 6 months.
• The visual analog scale (VAS) score being at least 3 or more.
• Group 2 (Healthy control group) 1. Individuals with no signs or symptoms of Knee OA or other neurological or musculoskeletal conditions.

You may not qualify if:

• Patellar subluxation
• Surgery in any joint of the lower limb
• Meniscal injury
• Ligament instability
• Patients who received intra-articular injection in the knee in the last 6 months
• Patients with problems in the hip and ankle
• Patients who participated in in another physical therapy program in the last 3 months were not included in the study.

Sponsors & Collaborators

• Ahram Canadian University: lead

Study Sites (1)

Outpatient clinic of faculty of physical therapy, Ahram Canadian University

Al Ḩayy Ath Thāmin, Giza Governorate, 3221405, Egypt

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Abeer Abdelrahman, Ph.D

  Cairo University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Electromyography lab

Study Record Dates

• First Submitted: September 26, 2023
• First Posted: October 3, 2023
• Study Start: July 20, 2023
• Primary Completion: February 2, 2024
• Study Completion: February 2, 2024
• Last Updated: August 6, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)