NCT06062836|UnknownDMC
The Platform for Interdisciplinary Cardiovascular-metabolic-neurovascular Diseases (PICMAN)
PICMAN
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PICMAN
Sponsor study identifier
observational
120
1 country
1
Study Start
April 1, 2022
Actual (reported)Primary Completion
December 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
April 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Background Changes in metabolism and mitochondrial function appear to precede cardiac dysfunction, with much evidence supporting metabolic dysregulation as one of the earliest precursors of cardiovascular disease. We hypothesise that quantifiable metabolic inflexibility may be representative of an individual in his/her silent, but high-risk progression towards insulin resistance, diabetes and cardiovascular disease. The platform for interdisciplinary cardiovascular-metabolic-neurovascular diseases (PICMAN) across National University Health System (NUHS) is a pilot, prospective, multi-ethnic cohort study in Singapore. Through extensive phenotyping in a preventive cardiology cohort, the central aim is to define the metabolic flexibility range in a cohort of individuals at elevated risk of atherosclerotic cardiovascular disease, to correlate metabolic flexibility to measures of cardiometabolic health, including diastolic dysfunction, coronary and cerebral atherosclerosis, body fat distribution and severity of non-alcoholic fatty liver disease.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 1, 2022
Actual (reported)April 10, 2023
Actual (reported)October 2, 2023
Actual (reported)December 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
April 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Metabolic flexibility
Metabolic flexibility will be calculated (deltaRQ)
Up to 5 years
Participants between the ages of 21 and 70 at screening without a prior history of MACE, coronary artery disease diagnosis, established diabetes, with a calculated 10-year ASCVD risk \> 5% based on QRISK3 calculator are eligible for PICMAN. Recruitment of individuals takes place at NUHS, where community-dwelling individuals without cardiac disease will be referred via outreach to primary care and community partners in Singapore.
National University Health System
Singapore, Singapore
Molecular phenotyping via 1. Analysis of peripheral blood mononuclear cells (PBMC) for immunometabolic profile analysis 2. Analysis of genomics and microbiome analysis using exosome isolates, stool and urine samples 3. "Omits" profiling covering their genomics, epigenomics, transcriptomics, and proteomics via differentiation of patient-derived iPSCs into cardiac cell-types
Mayank Dalakoti
National University Health System
Roger Foo
National University Health System
First Submitted
April 10, 2023
First Posted
October 2, 2023
Study Start
April 1, 2022
Actual (reported)Primary Completion
December 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Spices for Cultivating a Healthy Gut Microbiome and Cardiometabolic Profile
Contact the study team to confirm eligibility.
Study Completion
April 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
October 2, 2023
Record last verified: 2023-04
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Source: ClinicalTrials.gov.
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