Effects of Peppermint Oil in Cardiometabolic Outcomes
Effects of Oral Peppermint Supplementation on Cardiometabolic Parameters
1 other identifier
interventional
36
1 country
1
Brief Summary
Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount. Dietary interventions to improve cardiometabolic health are highly sought after as they possess less risk than pharmacological drugs. Previous non-randomized interventions have shown that oral peppermint may be beneficial in improving cardiometabolic outcomes. However, to date, no research has explored this using a placebo randomized intervention. Therefore, the primary purpose of the proposed investigation is to test the ability of oral peppermint oil supplementation to improve cardiometabolic parameters in healthy individuals.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Nov 2021
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 28, 2021
CompletedFirst Posted
Study publicly available on registry
October 8, 2021
CompletedStudy Start
First participant enrolled
November 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 15, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
November 5, 2022
CompletedMarch 31, 2023
March 1, 2023
10 months
September 28, 2021
March 28, 2023
Conditions
Outcome Measures
Primary Outcomes (2)
Systolic blood pressure
Systolic blood pressure - measured using a digital blood pressure monitor
Baseline
Systolic blood pressure
Systolic blood pressure - measured using a digital blood pressure monitor
20 days
Secondary Outcomes (34)
Percent bodyfat
Baseline
Percent bodyfat
20 days
Waist to hip ratio
20 days
Waist to hip ratio
Baseline
Resting metabolic rate
Baseline
- +29 more secondary outcomes
Study Arms (2)
Placebo
PLACEBO COMPARATORIdentical in taste and colour to the supplement juice, but with no peppermint content.
Peppermint oil
EXPERIMENTAL50 uL of peppermint oil, which will be diluted with 100 mL of water - taken twice per day.
Interventions
Eligibility Criteria
You may qualify if:
- Healthy
- Between 18 \& 65 years
- Non-smoker
- BMI \< 30
- Able to give informed consent
You may not qualify if:
- Pregnancy
- Diabetes or any other metabolic/ uncontrolled hypertensive conditions
- Food allergies to peppermint
- Habitual consumption of peppermint
- Not regularly taking medication or antioxidant supplements
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Jonathan Sinclair
Preston, Lancashire, PR4 0PE, United Kingdom
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
September 28, 2021
First Posted
October 8, 2021
Study Start
November 1, 2021
Primary Completion
August 15, 2022
Study Completion
November 5, 2022
Last Updated
March 31, 2023
Record last verified: 2023-03