Pericapsular Nerve Group Block: An Imaging Study for Determination of the Spread of the Injectate Using 3-D CT Scan

NCT06062134 | Completed

• 1 other identifier: 2023-146
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Over the last 20 years, different interventional regional analgesia techniques have been proposed to treat pain after hip surgeries. The most commonly used techniques are the fascia iliaca and femoral nerve blocks, resulting in reduced pain scores, opioid-sparing effects, and opioid-related adverse effects. However, these interventional analgesia techniques result in a motor block and muscle weakness of the quadriceps muscle, impeding early ambulation and rehabilitation. Recently, the pericapsular nerve group (PENG) block has been proposed as an effective choice for analgesia after hip surgeries while sparing the motor function of the lower extremities. The aim of this technique is to inject local anesthetic to target the more distal sensory branches innervating the anterior aspect of the hip joint.

Conditions

Post Operative Pain; Mechanisms of Analgesia

Outcome Measures

Primary Outcomes (1)

• Concentration of the local anesthetic reaching specific anatomical areas of interest around the hip joint

  Computed tomography images will be used as measurement tool

  2 hours

Study Arms (1)

Pericapsular nerve group block group

EXPERIMENTAL

All subjects enrolled in the study received a pericapsular nerve group block using a local anesthetic mixed with a contrast agent. After injection, subjects were transferred to the CT scan to obtain a 3D reconstruction to determine the spread of the injectate.

Procedure: Pericapsular nerve group block; Drug: 18 mL ropivacaine 0.5% + 2 mL radiopaque contrast

Interventions

Pericapsular nerve group block PROCEDURE

Ultrasound-guided injection of local anesthetic mixed with contrast agent underneath the iliopsoas muscle, lateral to the iliopsoas tendon.

Pericapsular nerve group block group

18 mL ropivacaine 0.5% + 2 mL radiopaque contrast DRUG

20 mL of injectate: 18 mL ropivacaine 0.5% + 2 mL radiopaque contrast (Iomeron 300: 61.24% w/v of iomeprol equivalent to 30% iodine or 300 mg iodine/mL)

Pericapsular nerve group block group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• an indication for PENG blocks for postoperative pain management
• American Society of Anesthesiologists (ASA) physical status I or II
• at least 18 years old, and able to understand the purpose and risks of the study

You may not qualify if:

• pregnancy
• body mass index above 35 kg/m2
• hepatic or renal insufficiency
• history of allergic or adverse reactions to local anesthetics or contrast agents.

Sponsors & Collaborators

• Philippe Gauthier: lead

Study Sites (1)

Clinique Ste Anne-St Remi

Brussels, 1070, Belgium

Location

Related Publications (1)

• Balocco AL, Gautier N, Van Boxstael S, Lopez AM, Carella M, Corten K, Sala-Blanch X, Hadzic A, Gautier PE. Pericapsular nerve group block: a 3D CT scan imaging study to determine the spread of injectate. Reg Anesth Pain Med. 2025 Jul 4;50(7):588-591. doi: 10.1136/rapm-2024-105459.

  PMID: 38925712 DERIVED

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Ropivacaine

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Officials

• Philippe Gautier

  Anesthesiologist

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: No masking was required for this study.
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Model Details: All subjects enrolled in the study received the same interventional regional analgesia technique (the pericapsular nerve group block) as part of the standard multimodal analgesia protocol. The local anesthetic was mixed with a radiocontrast agent in order to evaluate the spread of the injectate by using CT scan imaging.

Study Record Dates

• First Submitted: August 5, 2023
• First Posted: October 2, 2023
• Study Start: October 18, 2023
• Primary Completion: December 21, 2023
• Study Completion: December 21, 2023
• Last Updated: May 29, 2024

Record last verified: 2024-05

Locations

BE (1)