Helix Research Network
HRN
1 other identifier
observational
2,000,000
1 country
14
Brief Summary
The Helix Research Network ("HRN") is a network of academic, public, and/or private healthcare organizations that are committed to advancing medical research and improving human health through large-scale genomics research and acceleration of the integration of genomic and other omics data into clinical care.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2021
Longer than P75 for all trials
14 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 13, 2021
CompletedFirst Submitted
Initial submission to the registry
August 18, 2023
CompletedFirst Posted
Study publicly available on registry
September 28, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 13, 2031
ExpectedStudy Completion
Last participant's last visit for all outcomes
September 13, 2036
March 23, 2026
March 1, 2026
10 years
August 18, 2023
March 19, 2026
Conditions
Outcome Measures
Primary Outcomes (6)
Establish a Research Network
Establish a research network to support the advancement of biomedical research, improve human health through genomics research, and accelerate integration of genomic and other omics data into clinical care.
Through study completion, average 10 years
Aggregate data
Aggregate molecular, genomic data, phenotypic and other health-related data in centralized and/or federated databases to be accessed by investigators for approved research purposes.
Through study completion, average 10 years
Re-Contact participants
Recontact participants for additional data collection, research participation opportunities, and return of results
Through study completion, average 10 years
Genetic biomarker identification
Identification and characterization of clinical, histological, molecular, and genetic biomarkers that are linked to disease, disease outcomes, or that might be used to improvise disease classification.
Through study completion, average 10 years
Exploration of genetic determinants of disease
Exploration of the molecular and genetic underpinnings and determinants of disease, including disease risk, disease progression, treatment response, health economic outcomes, social or behavioral determinants of health, targets for therapeutic intervention, risk stratification, and other clinical indicators of interest.
Through study completion, average 10 years
Collection and analysis of Patient Reported Outcomes
Collection and analysis of Patient Reported Outcomes (e.g. quality of life, physical function, symptom burden) associated with diseases that have a genetic or molecular etiology. Validation of disease-specific instruments to assess the impact of genetic screening.
Through study completion, average 10 years
Interventions
Exome sequencing will be completed on each sample submitted.
Eligibility Criteria
The study will recruit the general population from the surrounding areas of the HRN Member Sites. This may include patients within a health system of the Site or community members in the surrounding area of Sites.
You may qualify if:
- years and older
- Willing and able to comply with all aspects of the protocol
You may not qualify if:
- History of allogenic bone marrow transplant
- History of allogenic stem cell transplant
- Anything that would place the individual at increased risk or preclude an individual's: 1) full compliance with study requirements; or 2) completion of the study based on the assessment from local consenting and enrolling Investigators.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Helix, Inclead
- Medical University of South Carolinacollaborator
- HealthPartners Institutecollaborator
- Memorial Hermann Health Systemcollaborator
- WellSpan Healthcollaborator
- St. Luke's Hospital and Health Network, Pennsylvaniacollaborator
- Sanford Healthcollaborator
- Renown Healthcollaborator
- WakeMed Health and Hospitalscollaborator
- University of Nebraskacollaborator
- Ohio State Universitycollaborator
- Cone Healthcollaborator
- Parkview Healthcollaborator
- Rochester Regional Healthcollaborator
- University Health Network, Torontocollaborator
Study Sites (14)
Parkview Health (DNA Insights)
Fort Wayne, Indiana, 46845, United States
HealthPartners (myGenetics)
Bloomington, Minnesota, 55425, United States
Nebraska Medicine - University of Nebraska Medical Center (Genetic Insights Project)
Omaha, Nebraska, 68198, United States
Renown Health (Healthy Nevada Project)
Reno, Nevada, 89502, United States
Rochester Regional Health (GenoWell)
Rochester, New York, 14621, United States
Cone Health (Gene Connect)
Burlington, North Carolina, 27401, United States
WakeMed (PreciselyYou)
Raleigh, North Carolina, 27610, United States
TriHealth (DNA Discovery)
Cincinnati, Ohio, 45202, United States
The Ohio State University (Genomic Health)
Columbus, Ohio, 43210, United States
St. Luke's University Health Network (DNAanswers)
Bethlehem, Pennsylvania, 18015, United States
WellSpan Health (The Gene Health Project)
York, Pennsylvania, 17403, United States
Medical University of South Carolina (In Our DNA SC)
Charleston, South Carolina, 29425, United States
Sanford Health (Imagine You)
Sioux Falls, South Dakota, 57105, United States
Memorial Hermann Health System (genoME)
Houston, Texas, 77030, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
William Lee, PhD
Helix, Inc
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- ECOLOGIC OR COMMUNITY
- Time Perspective
- OTHER
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 18, 2023
First Posted
September 28, 2023
Study Start
September 13, 2021
Primary Completion (Estimated)
September 13, 2031
Study Completion (Estimated)
September 13, 2036
Last Updated
March 23, 2026
Record last verified: 2026-03
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- ICF, CSR
- Time Frame
- Data will be available for the duration of the study.
- Access Criteria
- An application to the Helix Research Network or a Member Site for Member Site level data.
As a population health research network, the primary purpose of HRN is to help researchers and clinicians better understand how genetic information may be used to improve the health of individuals and communities. It is possible that participants may receive actionable health information as a result of analysis of their DNA information. This means that the participant's genetic results may be used by their healthcare providers to inform medical decisions. It is also possible that novel discoveries may be generated from the research that could positively impact a participant's healthcare in the future.