Predictive Value of Right Atrial Strain in Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

NCT06054360 | Unknown

• 1 other identifier: PI2023_843_0048
• Study Type: observational
• Target: 334
• Locations: 1 country
• Sites: 1

Brief Summary

The incidence of postoperative atrial fibrillation (POAF) after cardiac surgery is around 30%. POAF increases the risk of developing permanent atrial fibrillation and raises the risk of cardiac decompensation, stroke, acute myocardial infarction, and death. While the role of the left atrium (LAF) in the pathophysiology of POAF is now well-established, the part of the right atrium (RA) remains poorly understood. Recent studies suggest a correlation between RA function and POAF. RA function can be assessed by transthoracic echocardiography (TTE) with dedicated software for measuring the RA strain (RAS). RA function is thus divided into three phases: reservoir (RASr), conduit, and contraction. Numerous studies have demonstrated that a significant alteration in RAS predicts POAF in various clinical contexts. Therefore, it is essential to investigate whether alterations in RA function assessed by 2D-STE (RAS) are associated with an increased occurrence of FAPO after cardiac surgery. It is essential to investigate whether alterations in RA function assessed by 2D-STE (RAS) are associated with an increased occurrence of FAPO after cardiac surgery.

Conditions

Postoperative Atrial Fibrillation; Strains

Keywords

coronary bypass grafting; postoperative atrial fibrillation; strain; left atrial; right atrial

Outcome Measures

Primary Outcomes (1)

• Correlation of RASr parameter variation with POAF incidence

  Correlation of RASr parameter variation with POAF incidence in patients undergoing postoperative cardiac surgery

  30 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This prospective, single-center study was conducted at the Amiens University Hospital. As an additional procedure to the patient's management, it includes the systematic performance of a TTE the day before the surgery, with the acquisition of specific views to measure RAS. After enrollment, the principal investigator will perform a TTE to measure RASr on particular views. TTE will be performed in a supine position at the patient's bedside by a trained medical operator, following a standardized protocol. After surgery, the patient will be monitored by a 5-lead ECG to diagnose POAF. The maximum duration of POAF monitoring will be seven days in the intensive care unit.

You may qualify if:

• Adult patient (\>18 years old)
• The patient was hospitalized at the Amiens University Hospital for scheduled aortocoronary bypass grafting under cardiopulmonary bypass.
• Echocardiographic image quality enabling the measurement of RAS parameters
• Patient affiliation to a social security scheme
• Patient/proxy information and collection of their non-opposition.

You may not qualify if:

• Patients participating in an interventional study may modify the incidence of POAF.
• History of atrial fibrillation or flutter.
• Valvular and ascending aorta cardiac surgery
• Urgent cardiac surgery.
• Presence of tricuspid insufficiency greater than grade 2.
• Left ventricular ejection fraction lower than 50%.
• Patient receiving circulatory mechanical assistance before surgery.
• Dependency on ventricular and atrial pacing by an internal or external cardiac pacemaker during the echocardiographic examination.

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens Picardie

Amiens, France

RECRUITING

MeSH Terms

Conditions

Sprains and Strains

Condition Hierarchy (Ancestors)

Wounds and Injuries

Central Study Contacts

Camille DAUMIN, MD

CONTACT

03 22 08 77 95; daumin.camille@chu-amiens.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 19, 2023
• First Posted: September 26, 2023
• Study Start: April 17, 2023
• Primary Completion: November 1, 2025
• Study Completion: November 1, 2025
• Last Updated: October 2, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)