A Study of the Oral EGFR Inhibitor PLB1004 in Non-Small Cell Lung Cancer

NCT06046495 | Recruiting Phase 1 FDA Drug

• 1 other identifier: PLB1004-I-US01
• Study Type: interventional
• Target: 81
• Locations: 1 country
• Sites: 7

Brief Summary

This is a Phase I, multicenter, open-label, dose escalation and dose expansion study to assess the safety and pharmacokinetic profile of PLB1004, a mono-anilino-pyrimidine compound, given alone in NSCLC patients with EGFR exon 20 insertion mutations，uncommon mutations, classical mutations (Ex19del and L858R), and drug-resistant mutation (T790M). Patients will be enrolled and dosed according to the most current protocol. This study is made of two Parts. Part 1 includes a dose escalation into 7 cohorts and patient allocation to these cohorts will be via slot allocation. Each cohort has a minimum of 3 and a maximum of 6 patients for a total of 21 - 42 patients. The patient population of the dose escalation phase will include patients with advanced NSCLC harboring EGFR classical mutations or Ex20ins mutations, or uncommon mutations. Part 2 includes an expansion phase and the expansion phase will explore one or more dose levels of PLB1004 in NSCLC patients with EGFR Ex20ins mutations, classical mutations, or uncommon mutations.

Conditions

Non-Small Cell Lung Cancer

Outcome Measures

Primary Outcomes (1)

• Safety profile of PLB1004 per CTCAE v5.0

  Up to 2 years

Secondary Outcomes (10)

• To define the DLTs and MTD

  Up to 3 years

• Area Under the Curve (AUC) of PLB1004

  Approximately 28 days.

• Maximum plasma concentration (Cmax) of PLB1004

  Approximately 28 days.

• Time to maximum plasma concentration (Tmax) of PLB1004

  Approximately 28 days.

• Overall Response Rate (ORR)

  Up to 3 years

Study Arms (1)

PLB1004

EXPERIMENTAL

PLB1004 given as a mono-therapy in dose escalation and dose expansion phase.

Drug: PLB1004

Interventions

PLB1004 DRUG

PLB1004 will be orally self-administered by the patient as a mono-therapy.

PLB1004

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Ability to understand and willingness to sign a written informed consent document;
• Male or female adult patients 18 years of age or older;
• Patients should have recovered from toxicities related to prior anti-tumor therapy;
• Patients should have recovered from the effects of major surgery;
• Have a documented EGFR mutation by a local test in tissue or plasma;
• At least 12 weeks life expectancy;
• Must have at least one measurable lesion per RECIST v 1.1;
• Sexually active males and females of childbearing potential must agree to take effective contraceptive measures.

You may not qualify if:

• Received radiotherapy within 14 days before enrollment;
• Have significant or uncontrolled systemic disease;
• Have significant or uncontrolled cardiovascular disease;
• Have had other diagnosed malignant diseases that required treatment within the past 3 years besides NSCLC;
• Currently have or had a history of interstitial lung disease, drug-induced interstitial lung disease, or radiation pneumonia that requires steroid therapy;
• Have known hypersensitivity to the similar drugs and excipients of PLB1004;
• Pregnant or lactating women;
• Have used other experimental drugs within 2 weeks prior to the first dose of PLB1004;
• Have any condition or illness that could affect the compliance with the protocol.

Sponsors & Collaborators

• Avistone Biotechnology Co., Ltd.: lead

Study Sites (7)

University of California-Davis

Sacramento, California, 95817-1514, United States

RECRUITING

Research Site

Louisville, Kentucky, 40202, United States

RECRUITING

Nebraska Cancer Specialists

Omaha, Nebraska, 68130, United States

RECRUITING

Research Site

New York, New York, 100021, United States

RECRUITING

Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States

RECRUITING

Swedish Health Sciences

Seattle, Washington, 98122, United States

RECRUITING

Research Site

Seattle, Washington, 98195, United States

RECRUITING

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Central Study Contacts

Avistone Clinical Study Information Center Center

CONTACT

+86-10-84148921; information.center@avistonebio.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 6, 2023
• First Posted: September 21, 2023
• Study Start: July 8, 2024
• Primary Completion (Estimated): February 9, 2028
• Study Completion (Estimated): February 9, 2028
• Last Updated: April 23, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (7)