Electrocardiographic Changes Among Epileptic and Non Epileptic Seizures in Children at Sohag University Hospital

NCT06045676 | Unknown

• 1 other identifier: Soh-Med-23-09-06MS
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

Epilepsy is a chronic disease triggered by increased impulsiveness of nerve cells in the brain and may require a lifelong treatment. Epilepsy is confirmed by two or more unprovoked seizures in more than 24 hours. Febrile Convulsion is another type of seizure occurring due to fever over 38 °C without a history of convulsion, CNS infection, electrolyte imbalance, metabolic disorder, intoxication, and trauma. Unlike epileptic seizures, there are non-epileptic seizures such as Breath Holding Spells that affect children's behaviors and often look like epileptic seizures. QT parameters elongation show the danger of dysrhythmia and unexpected sicknesses such as cardiomyopathy, mitral valve prolapse, ischemic coronary illness, and kidney disorders. Many investigators have reported changes in QT parameters in various diseases such as diabetes mellitus, celiac disease, thalassemia , epilepsy ,Breath holding spells and febrile seizure.

Conditions

Seizures

Outcome Measures

Primary Outcomes (1)

• QT interval

  Distance from the beginning of the Q wave to the end of the T wave at least in eight leads from the standard ECG

  12 months

Study Arms (5)

Drug Resistant Epilepsy

Seizures Not Respond to two lines of Anti epileptic Medications

Device: ECG

Drug Responsive Epilepsy

Seizures Respond to one or two lines of Anti epileptic Medications

Device: ECG

Febrile Seizures

type of seizure occurring due to fever over 38 °C without a history of convulsion

Device: ECG

Breath Holding Spells

children's behaviors look like epileptic seizures due to crying up to a minute followed by losing consciousness

Device: ECG

Control

Healthy Children free from any convulsion

Device: ECG

Interventions

ECG DEVICE

ECG with special comment on QT interval. QT interval was measured as the distance from the beginning of the Q wave to the end of the T wave at least in eight leads from the standard ECG.

Breath Holding Spells; Control; Drug Resistant Epilepsy; Drug Responsive Epilepsy; Febrile Seizures

Eligibility Criteria

• Age: 1 Year - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

children with drug resistant epilepsy , responsive epilepsy , febrile seizures and breath holding spells with age of 1 year to 12 years

You may qualify if:

• children with drug resistant epilepsy.
• febrile seizures.
• age of 1 year to 12 years.

You may not qualify if:

• age below 1 year and above 12 years
• children with convulsion secondary cns infection , encephalitis, encephalopathy , toxic and metabolic problem

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university Hospital

Sohag, Sohag, Egypt

Location

MeSH Terms

Conditions

Seizures

Interventions

Electrocardiography

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis

Central Study Contacts

Amany K El Zanaty, resident

CONTACT

01000465897; amanykhalaf@med.sohag.edu.eg

Mohamed M Fawaz, professor

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident

Study Record Dates

• First Submitted: September 13, 2023
• First Posted: September 21, 2023
• Study Start: September 25, 2023
• Primary Completion: September 25, 2024
• Study Completion: September 25, 2024
• Last Updated: September 28, 2023

Record last verified: 2023-09

Locations

EG (1)