Biomarkers and Risk Factors for Perioperative Neurocognitive Dysfunction in Elderly Patients

NCT06044207 | Unknown

• 1 other identifier: 2023-076-01
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Basic information and biological samples of patients were collected preoperatively and intraoperatively, and patients were divided into case and control groups by cognitive function assessment postoperatively, and risk factors and biomarkers of perioperative cognitive dysfunction were derived by analyzing and statistically processing basic information and biological samples.

Conditions

Perioperative Neurocognitive Dysfunction

Outcome Measures

Primary Outcomes (1)

• Perioperative neurocognitive dysfunction

  Identification of patients who develop perioperative neurocognitive disorders after surgery by postoperative follow-up with cognitive function tests

  1 year postoperative

Study Arms (2)

Patients with perioperative neurocognitive dysfunction

Diagnostic Test: Pittsburgh sleep quality index; Diagnostic Test: Self-rating depression scale; Diagnostic Test: Montreal Cognitive Assessment

Patients without perioperative neurocognitive dysfunction

Diagnostic Test: Pittsburgh sleep quality index; Diagnostic Test: Self-rating depression scale; Diagnostic Test: Montreal Cognitive Assessment

Interventions

Pittsburgh sleep quality index DIAGNOSTIC_TEST

The scale is suitable for evaluating sleep quality in patients with sleep disorders and psychiatric disorders, as well as for assessing sleep quality in the general population.

Patients with perioperative neurocognitive dysfunction; Patients without perioperative neurocognitive dysfunction

Self-rating depression scale DIAGNOSTIC_TEST

The scale is easy to use, can fairly intuitively reflect whether the patient has depression and the degree of depression, has been widely used in outpatient gross screening, mood state assessment.

Patients with perioperative neurocognitive dysfunction; Patients without perioperative neurocognitive dysfunction

Montreal Cognitive Assessment DIAGNOSTIC_TEST

The scale is a tool used for rapid screening of mild cognitive dysfunction to identify patients with preoperative cognitive dysfunction

Patients with perioperative neurocognitive dysfunction; Patients without perioperative neurocognitive dysfunction

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Elderly people older than 65 years old who have been identified for non-neurosurgical procedures at Jinan Central Hospital

You may qualify if:

• Age more than or equal to 65 years old
• ASA classification Ⅰ\~Ⅲ grade

You may not qualify if:

• History of previous Craniocerebral surgery or Craniocerebral trauma
• Inability to successfully complete preoperative psychological function tests
• Those who are severely deaf, speech impaired and otherwise unable to communicate.

Sponsors & Collaborators

• Jinan Central Hospital: lead

Study Sites (1)

Jinan Central Hospital

Jinan, Shandong, 250000, China

RECRUITING

Central Study Contacts

Wenying Chi, Master

CONTACT

18654557772; cwy2907@zxyy.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 12, 2023
• First Posted: September 21, 2023
• Study Start: June 1, 2023
• Primary Completion: June 1, 2025
• Study Completion: January 1, 2026
• Last Updated: September 21, 2023

Record last verified: 2023-05

Locations

CN (1)