Investigation of the Relationship Between Pain Sensitization and Diagnostic Parameters in Carpal Tunnel Syndrome

NCT06043141 | Completed

• 1 other identifier: 23-517
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this observational, cross-sectional study is to investigate the relationship between pain sensitization and ultrasonographic and nerve conduction studies in patients diagnosed with carpal tunnel syndrome (CTS). The main questions it aims to answer are:

• Can threshold values be determined ultrasonographically and electrodiagnostically in patients who develop pain sensitization?
• Are pressure pain threshold values and central sensitization inventory scores correlated with ultrasonographic and nerve conduction studies of the median nerve?

Conditions

Central Sensitisation; Carpal Tunnel Syndrome

Outcome Measures

Primary Outcomes (1)

• Pressure pian threshold

  Pain pressure threshold (PPT) is used to measure deep muscular tissue sensitivity. Algometer is used in the measurement and low values are interpreted in favor of increased sensitivity.

  3 months

Secondary Outcomes (8)

• Central sensitization inventory (CSI)

  3 months

• hand grip strength

  3 months

• Visual analog scale

  3 months

• Upper extremity nerve conduction studies

  3 months

• median nerve ultrasound

  3 months

Study Arms (2)

Patients with carpal tunnel syndrome

Patients with carpal tunnel syndrome

Diagnostic Test: Nerve ultrasound; Diagnostic Test: Nerve conduction studies; Diagnostic Test: Pressure pain threshold

Control group

Healthy control

Diagnostic Test: Nerve ultrasound; Diagnostic Test: Pressure pain threshold

Interventions

Nerve ultrasound DIAGNOSTIC_TEST

Ultrasonographic evaluation of the median nerve at the carpal tunnel and adjacent levels

Control group; Patients with carpal tunnel syndrome

Nerve conduction studies DIAGNOSTIC_TEST

Upper extremity nerve conduction studies including median-ulnar sensory and motor responses

Patients with carpal tunnel syndrome

Pressure pain threshold DIAGNOSTIC_TEST

Pain pressure threshold (PPT) is used to measure deep muscular tissue pain sensitivity.

Also known as: PPT

Control group; Patients with carpal tunnel syndrome

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with CTS

You may qualify if:

• Being diagnosed with carpal tunnel syndrome based on clinical and electrodiagnostic findings
• Agreeing to participate in the study

You may not qualify if:

• Concomitant history of diabetes, systemic inflammatory disease, active infection and malignancy
• Having a disease with neuropathic pain such as polyneuropathy, radiculopathy,multiple sclerosis
• Not agreeing to participate in the study
• History of surgery due to CTS

Sponsors & Collaborators

• Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey: lead

Study Sites (1)

Sultan Abdülhamid Han Training and Research Hospital

Istanbul, Uskudar, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Carpal Tunnel Syndrome

Interventions

Nerve Conduction Studies

Condition Hierarchy (Ancestors)

Median Neuropathy; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Nerve Compression Syndromes; Cumulative Trauma Disorders; Sprains and Strains; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis

Study Officials

• Emre Ata, Asst.Prof

  Saglik Bilimleri Universitesi

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist

Study Record Dates

• First Submitted: September 12, 2023
• First Posted: September 21, 2023
• Study Start: October 1, 2023
• Primary Completion: March 5, 2025
• Study Completion: May 30, 2025
• Last Updated: September 12, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)