Retrospective Analysis of Pain After Nerve Block in Surgical Patients

NCT06042322 | Active Not Recruiting

• 1 other identifier: 2023P000514
• Study Type: observational
• Target: 166
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a retrospective study looking at patients who received a nerve block for surgery and assessing pain after the nerve block resolves, with or without an educational intervention, over two periods of time.

Conditions

Acute Pain; Knee Osteoarthritis; Regional Anesthesia Morbidity

Outcome Measures

Primary Outcomes (1)

• Difference in maximum pain score, 0-10; (0 = no pain, 10 = worst pain)

  Difference in maximum pain score, numerical pain rating scale 0-10, 6-24 hours after nerve block between the two cohorts

  6-24 hours

Secondary Outcomes (5)

• Average pain score 0-10; (0 = no pain, 10 = worst pain)

  6-24 hours

• Difference in incidence of rebound pain

  6-24 hours

• Comparison of evening opioids given

  6-24 hours

• Difference in total opioids given

  6-24 hours

• Difference in length of stay

  0-2 years

Study Arms (2)

TKA with nerve block no intervention

Patients who received a single shot adductor canal nerve block prior to total knee arthroplasty surgery January 2017-June 2018

TKA with nerve block with intervention

Patients who received a single shot adductor canal nerve block prior to total knee arthroplasty surgery during March 2019-March 2020, and received an educational intervention

Other: Educational intervention

Interventions

Educational intervention OTHER

Multidisciplinary educational intervention was performed by orthopedic, anesthesia, and nursing team. This included a discussion of the patient's pain plan and a patient visit.

TKA with nerve block with intervention

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Using the Mass General Brigham Enterprise Data Warehouse, electronic health record data will be retrieved: adult patients, 18 years of age or older, who received a primary total knee arthroplasty, an adductor canal nerve block, pericapsular injection, and admitted to stay overnight (\>16 hours post nerve block).

You may qualify if:

• primary total knee arthroplasty
• received an adductor canal nerve block
• received pericapsular injection by surgeon intraoperatively
• admitted for overnight stay and \> 16 hours post-nerve block

You may not qualify if:

• age \< 18
• prior total knee arthroplasty on ipsilateral knee

Sponsors & Collaborators

• Brigham and Women's Hospital: lead

MeSH Terms

Conditions

Acute Pain; Osteoarthritis, Knee

Interventions

Early Intervention, Educational

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Child Health Services; Community Health Services; Health Services; Health Care Facilities Workforce and Services; Preventive Health Services

Study Officials

• Yun-Yun K Chen, MD

  Brigham and Women's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 29, 2023
• First Posted: September 18, 2023
• Study Start: January 1, 2017
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: April 28, 2026

Record last verified: 2026-04