Uterine Peristalsis in IVF

NCT06036459 | Not Yet Recruiting

• 1 other identifier: Uterine Peristalsis in IVF
• Study Type: observational
• Target: 117
• Locations: 0 countries
• Sites: N/A

Brief Summary

An observational prospective cohort study to evaluate the effect of uterine peristalsis at the time of embryo transfer on IVF clinical outcomes performed in Women's Health hospital, Assiut University, Egypt. Women performing fresh or frozen embryo transfer who do not have any uterine abnormalities will be included in the study

Conditions

Infertility, Female

Outcome Measures

Primary Outcomes (1)

• Clinical pregnancy

  The presence of intrauterine gestational sac and fetal pole with positive cardiac pulsation by transvaginal ultrasound

  2 weeks after a positive pregnancy test

Secondary Outcomes (5)

• Biochemical pregnancy

  2 weeks after embryo transfer

• Miscarriage

  From 6 weeks of gestation until 28 weeks of gestation

• Ectopic pregnancy

  the site of the gestational sac will be assessed 2 weeks after embryo transfer

• Ongoing pregnancy

  After 12 weeks of gestation until delivery

• Live birth

  From 28 weeks of gestation until delivery

Interventions

uterine peristalsis OTHER

Transabdominal us followed by Transvaginal ultrasonography scans (Sono Ace R5 ) of uterine peristalsis will performed on the day of embryo transfer while the patient lying relaxed in lithotomy position. The probe will be introduced into the vagina as gently as possible to avoid stimulating the cervix. After scanning the mid-sagittal plane of the uterus, the probe will be fixed as steady as possible while a 3 min video of uterine peristalsis will be recorded simultaneously. The records will be analyzed at 4X regular speed using a Video player application by two independent experienced observers. The uterine peristaltic wave frequency will be the mean of the results from each observer.

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women undergoing IVF

You may qualify if:

• Women undergoing embryo transfer during IVF cycles.
• Age: between 20 and 40 years.
• Have at least 1 good quality embryo at the time of transfer
• Fresh or frozen-thawed cycles.
• Any stimulation protocol in fresh cycles, or any endometrial preparation protocol for frozen-thawed cycles

You may not qualify if:

• Women refusing to participate in clinical research.
• Any uncorrected uterine abnormality, such as septum, myoma, adenomyosis, or polyp
• Hydrosalpinx without prior disconnection or excision

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Infertility, Female

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Infertility

Study Officials

• Mahmoud Abdelaziz, M.Sc

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Karim Abdallah, MD

CONTACT

+201270595485; karimsayed88@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator

Study Record Dates

• First Submitted: August 13, 2023
• First Posted: September 14, 2023
• Study Start: October 1, 2023
• Primary Completion: October 1, 2025
• Study Completion: June 1, 2026
• Last Updated: September 21, 2023

Record last verified: 2023-09