Laparoscopy in Failed IVF

NCT06165484 | Unknown

• 1 other identifier: failed IVF
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Current in-vitro fertilization (IVF) consumers are enjoying better success rates than early seekers, but only about a quarter of IVF cycles result in a live birth and many patients remain infertile after multiple IVF attempts. Recurrent IVF failure is distressing to patients and challenging to clinicians. Despite interventions have been proposed to improve IVF outcome after couples of failed cycles, only a few of which are evidence based. Laparoscopy, as the gold standard for the evaluation of the pelvis, was used to be the routine procedure for many reproductive physicians. It provides information on endometriosis, tubal patency, and pelvic adhesions and a chance to fix these lesions concurrently.

Conditions

Infertility, Female

Outcome Measures

Primary Outcomes (1)

• Improving the pregnancy outcome in patients with recurrent IVF failure.

  To assess if the diagnosis and treatment of pelvic or uterine pathologies with laparoscopy and hysteroscopy is of role in improving the pregnancy outcome (live birth rate and ongoing pregnancy rate) in patients with recurrent IVF failure .

  1.5 YEARS

Secondary Outcomes (1)

• Abnormal laparoscopy findings and surgery-related complications

  1.5 YEARS

Study Arms (1)

patient with failed ivf cycle

EXPERIMENTAL

Procedure: laparoscopy and hysteroscopy

Interventions

laparoscopy and hysteroscopy PROCEDURE

laparoscopy and hysteroscopy for patient with failed IVF

patient with failed ivf cycle

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \. The patients ages ranged from 20 to 40 years. 2. menstrual cycles with a duration of 24 to 38 days and no ovulatory dysfunction. 3. normal findings of pelvic ultrasonography and HSG assessment, without visible lesions that could cause implantation failure, for example: endometrial polyps, submucosal myomas, uterine septum and intrauterine adhesions.
• \. hormonal values were within the normal range. 5. Semen analyses were normal according to the World Health Organization (WHO) 2010 criteria.
• \. no previous surgical treatment for endometriosis; no previous oophorectomy or salpingectomy.
• \. Patients included in the study had failed to conceive after at least one cycles of IVF-ET when indicated.

You may not qualify if:

• \- 1. Couples with severe male factor infertility. 2. Premature ovarian failure. 3. Patients with a poor ovarian reserve and poor responders. 4. Contraindication to laparoscopy such as mechanical or large abdominal mass (\> 24 weeks gestation size).
• \. Contraindication to hysteroscopy such as recent or active pelvic inflammatory disease and active uterine bleeding.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Infertility, Female

Interventions

Laparoscopy; Hysteroscopy

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Infertility

Intervention Hierarchy (Ancestors)

Endoscopy; Diagnostic Techniques, Surgical; Diagnostic Techniques and Procedures; Diagnosis; Minimally Invasive Surgical Procedures; Surgical Procedures, Operative; Diagnostic Techniques, Obstetrical and Gynecological; Obstetric Surgical Procedures; Gynecologic Surgical Procedures; Urogenital Surgical Procedures

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: November 20, 2023
• First Posted: December 11, 2023
• Study Start: January 1, 2024
• Primary Completion: June 1, 2025
• Study Completion: November 1, 2025
• Last Updated: December 27, 2023

Record last verified: 2023-12