Multiplexing Prism Fitting for Field Expansion of Monocular Vision

NCT06027216 | Completed Results

• 2 other identifiers: 2023P001878R01EY031777
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators are developing an assistive device, known as multiplexing prism that expands the field of view for individuals with acquired monocular vision (loss of an eye). The investigators are testing a simplified design and fitting protocol to provide field expansion for individuals with acquired monocular vision.

Conditions

One Eye Blindness; Blind Left Eye; Blind Right Eye

Keywords

Field expansion; Collision detection; Walking; Response time

Outcome Measures

Primary Outcomes (1)

• Gain in Visual Field With the Multiplexing Prism

  Field expansion is calculated based on the difference of the maximum field of view on the nasal side of the seeing/functioning eye (same side as the blind eye) with and without multiplexing prism.

  Visit 2 of Study (approximately 2-3 weeks after 1st Visit)

Secondary Outcomes (1)

• Maximum Extent of Nasal Visual Field With the Multiplexing Prism

  Visit 2 of Study (approximately 2-3 weeks after 1st Visit)

Study Arms (1)

Field Expansion

EXPERIMENTAL

Field of view on the nasal side (same side as the blind eye) with and without multiplexing prism

Device: Multiplexing Prism

Interventions

Multiplexing Prism DEVICE

Multiplexing prism is designed for spatial vision multiplexing. It allows partial light transmission through the prism allow the observer to simultaneously see the physical world through the prism and see the "shifted view" from the non-seeing side. It is developed to expand the field of view of individuals with just one eye.

Field Expansion

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• No medical health issues such as seizures, motor movements problem
• Loss of vision in one eye (less than 20/200) for \>1 year)
• Visual acuity of the seeing eye: Better than 20/32 visual acuity with correction
• No visual field defect in the seeing eye (nasal field of at least \>45degree)
• No medical health issues such as seizures, motor movements problem

You may not qualify if:

• Patients with any physical or mental disabilities, including cognitive dysfunction, balance problems, or other deficits that could impair their ability to respond to the stimuli presented in this study will be excluded
• Any person with motor movements problem (e.g., unable to use extremities)

Sponsors & Collaborators

• Massachusetts Eye and Ear Infirmary: lead
• National Eye Institute (NEI): collaborator

Study Sites (1)

Schepens Eye Research Institute

Boston, Massachusetts, 02114, United States

Location

Related Publications (3)

• Jung JH, Peli E. Field Expansion for Acquired Monocular Vision Using a Multiplexing Prism. Optom Vis Sci. 2018 Sep;95(9):814-828. doi: 10.1097/OPX.0000000000001277.

  PMID: 30169357 BACKGROUND

• Jung JH, Peli E. No Useful Field Expansion with Full-field Prisms. Optom Vis Sci. 2018 Sep;95(9):805-813. doi: 10.1097/OPX.0000000000001271.

  PMID: 30169356 BACKGROUND

• Peli E, Jung JH. Multiplexing Prisms for Field Expansion. Optom Vis Sci. 2017 Aug;94(8):817-829. doi: 10.1097/OPX.0000000000001102.

  PMID: 28727615 BACKGROUND

MeSH Terms

Conditions

Blindness

Condition Hierarchy (Ancestors)

Vision Disorders; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Eli Peli
• Organization: Schepens Eye Research Institute, Mass Eye and Ear

eli_peli@meei.harvard.edu

617-912-2597

Study Officials

• Eli Peli, OD

  Schepens Eye Research Institute

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DEVICE FEASIBILITY
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Scientist

Model Details: Individuals with Acquired Monocular Vision/ Blindness in One Eye

Study Record Dates

• First Submitted: August 29, 2023
• First Posted: September 7, 2023
• Study Start: December 27, 2023
• Primary Completion: October 22, 2024
• Study Completion: December 31, 2024
• Last Updated: May 8, 2025
• Results First Posted: May 8, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)