Simulated Walking With Multiplexing Prism for Field Expansion in Monocular Vision

NCT06024668 | Terminated

• 2 other identifiers: 2023P001885R01EY031777
• Study Type: interventional
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators are developing an assistive device, known as multiplexing prism that expands the field of view for individuals with acquired monocular vision (loss of an eye). The investigators will test the efficacy of the prism in improving the detection of colliding pedestrians during a simulated walking task.

Conditions

Blind Left Eye; Blind Right Eye; One Eye Blindness

Keywords

Simulated Walking; Collision; Field Expansion; One eye blindness

Outcome Measures

Primary Outcomes (1)

• Mean response time to detect colliding pedestrian

  The investigators will compare the mean response time to detect colliding pedestrians coming from the nasal (same side as the blind eye) and temporal (same side as the seeing eye) visual field with and without multiplexing prism. The comparison will be made between these four: Nasal without prism, Temporal without prism, Nasal with prism, and Temporal with prism.

  Approximately 3 sessions, up to 3 hours for each session, any time within 4 month period

Secondary Outcomes (1)

• Pedestrian Detection Rate

  Approximately 3 sessions, up to 3 hours for each session, any time within 4 month period

Study Arms (1)

Detection of colliding pedestrian

EXPERIMENTAL

Participants will perform a simulated walking task in which surrounding pedestrians will walk towards and make a collision. Participants will respond by pressing buttons to indicate the direction of the colliding pedestrians. Participants will perform the task with and without the multiplexing prism in random orders.

Device: Multiplexing Prism

Interventions

Multiplexing Prism DEVICE

Multiplexing prism is designed for spatial vision multiplexing. It allows partial light transmission through the prism allow the observer to simultaneously see the physical world through the prism and see the "shifted view" from the non-seeing side. It is developed to expand the field of view of individuals with just one eye.

Detection of colliding pedestrian

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• No medical health issues such as seizures, motor movements problem
• Loss of vision in one eye (less than 20/200) for \>1 year
• Visual acuity of the seeing eye: Better than 20/32 visual acuity with correction
• No visual field defect in the seeing eye (nasal field of at least \>45degree)

You may not qualify if:

• Patients with any physical or mental disabilities, including cognitive dysfunction, balance problems, or other deficits that could impair their ability to respond to the stimuli presented in this study will be excluded
• Any person with a history (such as pacemaker use or photosensitive epilepsy)
• Any person with motor movements problem (e.g., unable to use extremities)

Sponsors & Collaborators

• National Eye Institute (NEI): collaborator
• Massachusetts Eye and Ear Infirmary: lead

Study Sites (1)

Schepens Eye Research Institute

Boston, Massachusetts, 02114, United States

Location

Related Publications (3)

• Jung JH, Castle R, Kurukuti NM, Manda S, Peli E. Field Expansion with Multiplexing Prism Glasses Improves Pedestrian Detection for Acquired Monocular Vision. Transl Vis Sci Technol. 2020 Jul 23;9(8):35. doi: 10.1167/tvst.9.8.35. eCollection 2020 Jul.

  PMID: 32855881 RESULT

• Jung JH, Peli E. Field Expansion for Acquired Monocular Vision Using a Multiplexing Prism. Optom Vis Sci. 2018 Sep;95(9):814-828. doi: 10.1097/OPX.0000000000001277.

  PMID: 30169357 RESULT

• Jung JH, Peli E. No Useful Field Expansion with Full-field Prisms. Optom Vis Sci. 2018 Sep;95(9):805-813. doi: 10.1097/OPX.0000000000001271.

  PMID: 30169356 RESULT

MeSH Terms

Conditions

Blindness

Condition Hierarchy (Ancestors)

Vision Disorders; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Eli Peli, OD

  Schepens Eye Research Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Scientist

Model Details: Individuals with Acquired Monocular Vision/ Blindness in One Eye

Study Record Dates

• First Submitted: August 29, 2023
• First Posted: September 6, 2023
• Study Start: August 4, 2024
• Primary Completion: December 31, 2024
• Study Completion: January 1, 2025
• Last Updated: April 14, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)