Koebner's Phenomenon in Psoriasis and Lichen Planus

NCT06021405 | Withdrawn

• 1 other identifier: 2023-00427
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Psoriasis and lichen planus often occur at mechanically irritated skin sites (e.g. tight clothing). The investigators would like to investigate this phenomenon in more detail in this study. For this purpose, the skin is specifically irritated at a small and cosmetically favorable site by tearing off scotch tape or rubbing with a wooden spatula. In order to be able to examine the inflammatory processes caused by the irritation more closely, a small skin sample and a skin swab are taken from the irritated area. This skin sample and the swab are repeated after three and fourteen days.

Conditions

Kobner Phenomenon; Psoriasis; Lichen Planus

Outcome Measures

Primary Outcomes (1)

• Differences in the transcriptomic profile comparing psoriasis patients with and without induced koebner phenomenon

  Transcriptomic profile at all timepoints (reads per 55µm diameter dot)

  Day 0, Day 3 (optional), Day 14 (optional)

Secondary Outcomes (3)

• Differences in the proteomic profile comparing psoriasis patients with and without induced koebner phenomenon

  Day 0, Day 3 (optional), Day 14 (optional)

• Characterization of involved immune cells in the skin comparing psoriasis patients with and without induced koebner phenomenon

  Day 0, Day 3 (optional), Day 14 (optional)

• Characterization of skin mikrobiome

  Day 0, Day 3, Day 14

Study Arms (1)

Tape stripping

EXPERIMENTAL

Procedure: Tape stripping

Interventions

Tape stripping PROCEDURE

a small area of skin will be tape-stripped with adhesive tape for up to 40 times and/or rubbed with a wooden spatula until the skin shows a slight erythema

Tape stripping

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Dermatologist diagnosed psoriasis (group psoriasis), lichen planus (group lichen planus) or no skin disease (group healthy controls)
• Subject is capable of giving informed consent
• Signed informed consent

You may not qualify if:

• Use of systemic immunosuppressive/immunmodulating agents in the last three months
• Use of topical anti-inflammatory treatment in the last 7 days in the area of sampling.
• Phototherapy in the last 4 weeks
• Active or recurrent serious bacterial, fungal or viral infection at the time of enrollment by patient history, including patients with Human Immunodeficiency Virus (HIV) infection, Hepatitis B and Hepatitis C infection, active or untreated latent tuberculosis.
• Female patients of childbearing potential who are pregnant or breast feeding or planning a pregnancy during the duration of the trial and/or not practicing acceptable birth control for the duration of the trial
• Known or suspected non-compliance, drug or alcohol abuse,
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant,
• Previous enrolment into the current study,
• Enrolment of the investigator, his/her family members, employees and other dependent persons.

Sponsors & Collaborators

• Marie-Charlotte Brüggen: lead

MeSH Terms

Conditions

Psoriasis; Lichen Planus

Condition Hierarchy (Ancestors)

Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases; Lichenoid Eruptions

Study Officials

• Marie-Charlotte Brüggen, MD PhD

  University of Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Prof. Dr. med. PhD

Study Record Dates

• First Submitted: August 11, 2023
• First Posted: September 1, 2023
• Study Start: September 1, 2025
• Primary Completion: September 20, 2025
• Study Completion: September 20, 2025
• Last Updated: March 17, 2026

Record last verified: 2025-03