Retrospective Study of the Protective Effect of Gastrodin on Myocardium in Patients Undergoing Cardiac Surgery

NCT06012994 | Completed

• 1 other identifier: mzk202303
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

Retrospective collection of Wuhan Union hospital from December 1,2018 to June 30,2021 to meet the entry and discharge standards. The patient 's medical record data were divided into study group and control group according to the use of gastrodin during operation. The perioperative data and prognostic outcomes in the patient 's medical records were collected and analyzed. The degree of myocardial injury and postoperative clinical outcomes were compared between the two groups.

Conditions

Cardiac Surgical Procedures

Outcome Measures

Primary Outcomes (1)

• The degree of myocardial injury

  The myocardial tissue trimmed by the surgeon according to the surgical requirements was collected during the operation for electron microscopy observation and detection of related molecular content.

  The myocardial tissue was collected during the operation. About 2 hours on average

Study Arms (2)

GAS

Control

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study included patients who were preoperatively diagnosed as requiring elective thoracic cardiac surgery under general anesthesia.

You may qualify if:

• Patients aged≥18 years, regardless of gender;
• Patients undergoing elective cardiac surgery under general anesthesia;
• ASA grade 1 \~ 3.

You may not qualify if:

• Suffering from more serious genetic diseases (such as immunodeficiency, thalassemia, etc.);
• Moderate to severe malnutrition, moderate to severe anemia;
• Persistent infection;
• Severe preoperative underlying diseases (such as severe liver and kidney dysfunction)

Sponsors & Collaborators

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology: lead

Study Sites (1)

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430022, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 20, 2023
• First Posted: August 28, 2023
• Study Start: December 1, 2018
• Primary Completion: June 30, 2021
• Study Completion: July 31, 2023
• Last Updated: August 28, 2023

Record last verified: 2023-08

Locations

CN (1)