NCT06009939|Completed
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Sponsor study identifier
observational
48
1 country
1
Study Start
March 1, 2023
Actual (reported)Primary Completion
September 14, 2023
Actual (reported)Study Completion
September 14, 2023
Actual (reported)The goal of this observational study is to learn more about the microcirculation in the skin by examining sex and age-related day-to-day variability in healthy subjects. The main questions the trial aims to answer are:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 14, 2023
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 1, 2023
Actual (reported)August 9, 2023
Actual (reported)August 24, 2023
Actual (reported)September 14, 2023
Actual (reported)September 14, 2023
Actual (reported)Speed-resolved perfusion
\[% RBC ×mm/s\]
Measured during 45 minutes and at one more occasion for 45 minutes within one week.
Red blood cell tissue fraction
\[% RBC\]
Measured during 45 minutes and at one more occasion for 45 minutes within one week.
Oxygen saturation
\[% oxygen\]
Measured during 45 minutes and at one more occasion for 45 minutes within one week.
Vessel diameter
\[μm\]
Measured during 45 minutes and at one more occasion for 45 minutes within one week.
Foot: 10 minutes of baseline measurement, 5 minutes of occlusion and 5 minutes of Post-occlusive reactive hyperemia (PORH) measurement. Arm: 10 minutes of baseline measurement, 5 minutes of occlusion and 5 minutes of Post-occlusive reactive hyperemia (PORH) measurement.
Foot: 10 minutes of baseline measurement, 5 minutes of occlusion and 5 minutes of Post-occlusive reactive hyperemia (PORH) measurement. Arm: 10 minutes of baseline measurement, 5 minutes of occlusion and 5 minutes of Post-occlusive reactive hyperemia (PORH) measurement.
Foot: 10 minutes of baseline measurement, 5 minutes of occlusion and 5 minutes of Post-occlusive reactive hyperemia (PORH) measurement. Arm: 10 minutes of baseline measurement, 5 minutes of occlusion and 5 minutes of Post-occlusive reactive hyperemia (PORH) measurement.
Foot: 10 minutes of baseline measurement, 5 minutes of occlusion and 5 minutes of Post-occlusive reactive hyperemia (PORH) measurement. Arm: 10 minutes of baseline measurement, 5 minutes of occlusion and 5 minutes of Post-occlusive reactive hyperemia (PORH) measurement.
A blood pressure cuff occludes the circulation in the upper arm as well as around the ankle.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
12 healthy men and 12 healthy women aged 20-30 years old. 12 healthy men and 12 healthy women aged 50-60 years old. In total 48 participants will be included.
Linköping University
Linköping, Östergötland County, 58185, Sweden
Hultman M, Larsson M, Stromberg T, Henricson J, Iredahl F, Fredriksson I. Flowmotion imaging analysis of spatiotemporal variations in skin microcirculatory perfusion. Microvasc Res. 2023 Mar;146:104456. doi: 10.1016/j.mvr.2022.104456. Epub 2022 Nov 18. No abstract available.
Fredriksson I, Larsson M, Stromberg T, Iredahl F. Vasomotion analysis of speed resolved perfusion, oxygen saturation, red blood cell tissue fraction, and vessel diameter: Novel microvascular perspectives. Skin Res Technol. 2022 Jan;28(1):142-152. doi: 10.1111/srt.13106. Epub 2021 Nov 10.
Fredrik Iredahl
Linköping University, Department of Health, Medicine and Caring Sciences
48 participants (actual enrollment reported by the registry).
First Submitted
August 9, 2023
First Posted
August 24, 2023
Study Start
March 1, 2023
Actual (reported)Contact the study team to confirm eligibility.
Hultman M, Larsson M, Stromberg T, Fredriksson I. Real-time video-rate perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning. J Biomed Opt. 2020 Nov;25(11):116007. doi: 10.1117/1.JBO.25.11.116007.
Hultman M, Larsson M, Stromberg T, Fredriksson I. Speed-resolved perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning. J Biomed Opt. 2023 Mar;28(3):036007. doi: 10.1117/1.JBO.28.3.036007. Epub 2023 Mar 20.
Primary Completion
September 14, 2023
Actual (reported)Study Completion
September 14, 2023
Actual (reported)Last Updated
September 18, 2023
Record last verified: 2023-09
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Source: ClinicalTrials.gov.
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