The Relationship Between Pectus Deformities and Spinal Pathologies

NCT06009601 | Completed

• 1 other identifier: 397
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Pectus deformities are common anterior chest wall pathologies. Pectus excavatum is the most common chest deformity with an incidence of 0.1-0.3%. Although the incidence of adolescent idiopathic scoliosis (AIS) is 0.2-3% in the community, some studies show that this rate rises to 17.61-25.58% when it is associated with pectus deformity. While the pectus excavatum rotates the heart to the left with its ribs and cartilages, it pushes the thoracic vertebra to the right side with the internal counterforce created by the heart, which has been shown to push the spine to the right with an asymmetric horizontal force in scoliosis patients with pectus deformity. Based on this, in study, investigators aimed to determine whether there is any relationship between pectus deformities and spinal pathologies, and if there is a relationship, with which pathology it is most common, whether the type of scoliosis seen in pectus deformities with a prominent scoliosis prevalence is a pectus-specific curve, and whether this curve seen in scoliosis is associated with pectus. To determine whether there is a footprint or not.

Conditions

Pectus Deformity of Chest; Spinal Deformity

Keywords

Pectus Excavatum; Pectus Carinatum; Scoliosis; Kyphosis; Lordosis

Outcome Measures

Primary Outcomes (3)

• Pectus Study Form

  In the Pectus Study Form, the clinical and radiological data of the patient will be evaluated. Coronal, sagittal balance and coronal and sagittal cobb angles of the patient will be measured in the scoliosis X-ray.

  Within 1 week of applying to the scoliosis outpatient clinic

• Pulmonary Function Test (PFT)

  Pulmonary function test measurements will be made for people with pectus deformity.Pulmonary function tests, or PFTs, measure how well the lungs work. For some of the test measurements, the client can breathe normally and quietly. Other tests require forced inhalation or exhalation after a deep breath. Sometimes, they will be asked to inhale a different gas or a medicine to see how it changes test results.

  Within 1 week of applying to the scoliosis outpatient clinic

• Body Aesthetic Clinical Evaluation (TRACE)

  Body Aesthetic Clinical Evaluation (TRACE) measurement will be performed.TRACE is a 12-point scale based on four sub-scales, shoulders (0-3), scapulae (0-2), hemi-thorax (0-2) and waist (0-4)

  Within 1 week of applying to the scoliosis outpatient clinic

Secondary Outcomes (7)

• Quality of Life Evaluation Form in Pectus Deformity

  Within 1 week of applying to the scoliosis outpatient clinic

• Social Comparison Scale

  Within 1 week of applying to the scoliosis outpatient clinic

• Sleep Disorder Scale for Children

  Within 1 week of applying to the scoliosis outpatient clinic

• Anxiety Disorders Screening Scale in Children

  Within 1 week of applying to the scoliosis outpatient clinic

• The Pediatric Quality of Life Inventory

  Within 1 week of applying to the scoliosis outpatient clinic

Study Arms (1)

Patients aged 3-18 years who were diagnosed with pectus deformity

Pectus study forms consisting of clinical and radiological measurements of patients aged 3-18 years who applied to the outpatient clinic with chest deformity will be filled in in detail.

Diagnostic Test: Pectus Study Form; Diagnostic Test: Adams Test; Diagnostic Test: Scoliosis Graphy; Diagnostic Test: Pulmonary function test

Interventions

Pectus Study Form DIAGNOSTIC_TEST

Pectus study forms consisting of clinical and radiological measurements of patients aged 3-18 years who applied to the outpatient clinic with chest deformity will be filled in in detail. In addition, this study form includes 'Quality of Life Evaluation Form in Pectus Deformity', 'Social Comparison Scale', 'Sleep Disorder Scale for Children', 'Anxiety Disorders Screening Scale in Children', 'Pediatric Quality of Life Questionnaire' designed for patients and their relatives. PedsQL)', 'SRS-22 Patient Questionnaire', 'Beck Anxiety Scale' and 'Informed Consent Form' designed for patients and their relatives.

Patients aged 3-18 years who were diagnosed with pectus deformity

Adams Test DIAGNOSTIC_TEST

Adams test (forward bending test) (+) was measured by Bunnell scoliometer (scoliosis assessment tool) and ATR (angle of trunk rotation angle) values were 7 degrees in patients who meet the inclusion criteria will be included in the study by filling out an informed consent form

Also known as: Forward Bending Test

Patients aged 3-18 years who were diagnosed with pectus deformity

Scoliosis Graphy DIAGNOSTIC_TEST

ATR (angle of trunk rotation) values above 7 degrees on bunnell scoliometer were determined. Afterwards, patients who meet the inclusion criteria will be included in the study by filling out an informed consent form and a scoliosis graphy will be requested. Coronal, sagittal balance; coronal and sagittal cobb angles will be measured from posterior-anterior (PA) (posterior-anterior) and lateral (lateral) scoliosis radiographs.

Also known as: Orthoroentgenogram

Patients aged 3-18 years who were diagnosed with pectus deformity

Pulmonary function test DIAGNOSTIC_TEST

Pulmonary function tests (PFTs) are noninvasive tests that show how well the lungs are working. The tests measure lung volume, capacity, rates of flow, and gas exchange. This information can help your healthcare provider diagnose and decide the treatment of certain lung disorders. There are 2 types of disorders that cause problems with air moving in and out of the lungs: Obstructive. This is when air has trouble flowing out of the lungs due to airway resistance. This causes a decreased flow of air. Restrictive. This is when the lung tissue and/or chest muscles can't expand enough. This creates problems with air flow, mostly due to lower lung volumes.

Also known as: Spirometry Function Test

Patients aged 3-18 years who were diagnosed with pectus deformity

Eligibility Criteria

• Age: 3 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Pectus study forms consisting of clinical and radiological measurements of patients aged 3-18 years who applied to the outpatient clinic with chest deformity will be filled in in detail. Adams test (forward bending test) (+) was measured by Bunnell scoliometer (scoliosis assessment tool) and ATR (angle of trunk rotation angle) values were 5 degrees in those with BMI (Body Mass Index) above 85%. If it is below 85% and above 7 degrees, patients who meet the inclusion criteria will be included in the study by filling out an informed consent form and a scoliosis film will be requested. Scoliosis X-ray (orthorontgenogram) will be requested. Coronal, sagittal balance, coronal and sagittal cobb angles will be measured. Their relationship with chest deformities will be evaluated. All measurements will be made and recorded by two independent researchers.

You may qualify if:

• Being diagnosed with pectus deformity
• Be between 3-18 years old

You may not qualify if:

• Adult type scoliosis
• Congenital scoliosis
• Neuromuscular scoliosis
• Syndromic scoliosis
• Infantile idiopathic scoliosis
• Having surgery to the chest wall or spine
• People with connective tissue disease will not be included in the study.

Sponsors & Collaborators

• Gaziosmanpasa Research and Education Hospital: lead

Study Sites (1)

Deniz

Gaziosmanpaşa, Istanbul, 34255, Turkey (Türkiye)

Location

Related Publications (8)

• Zhong W, Ye J, Feng J, Geng L, Lu G, Liu J, Zhang C. Effects of Pectus Excavatum on the Spine of Pectus Excavatum Patients with Scoliosis. J Healthc Eng. 2017;2017:5048625. doi: 10.1155/2017/5048625. Epub 2017 Jul 3.

  PMID: 29065615 RESULT

• Tomaszewski R, Wiktor L, Machala L. Evaluation of thoracic vertebrae rotation in patients with pectus excavatum. Acta Orthop Traumatol Turc. 2017 Jul;51(4):284-289. doi: 10.1016/j.aott.2017.03.005. Epub 2017 Jun 16.

  PMID: 28624480 RESULT

• Tauchi R, Kawakami N, Tsuji T, Ohara T, Suzuki Y, Saito T, Nohara A. Evaluation of thoracic factors after scoliosis surgery in patients with both scoliosis and pectus excavatum. Eur Spine J. 2018 Feb;27(2):381-387. doi: 10.1007/s00586-016-4753-4. Epub 2016 Aug 27.

  PMID: 27568387 RESULT

• Alaca N, Yuksel M. Comparison of physical functions and psychosocial conditions between adolescents with pectus excavatum, pectus carinatum and healthy controls. Pediatr Surg Int. 2021 Jun;37(6):765-775. doi: 10.1007/s00383-021-04857-7. Epub 2021 Jan 16.

  PMID: 33454849 RESULT

• Iscan M, Kilic B, Turna A, Kaynak MK. The effect of minimally invasive pectus excavatum repair on thoracic scoliosis. Eur J Cardiothorac Surg. 2020 Oct 30:ezaa328. doi: 10.1093/ejcts/ezaa328. Online ahead of print.

  PMID: 33123728 RESULT

• Tauchi R, Suzuki Y, Tsuji T, Ohara T, Saito T, Nohara A, Morishita K, Yamauchi I, Kawakami N. Clinical Characteristics and Thoracic factors in patients with Idiopathic and Syndromic Scoliosis Associated with Pectus Excavatum. Spine Surg Relat Res. 2018 Jan 27;2(1):37-41. doi: 10.22603/ssrr.2017-0027. eCollection 2018.

  PMID: 31440644 RESULT

• van Es LJM, van Royen BJ, Oomen MWN. Clinical significance of concomitant pectus deformity and adolescent idiopathic scoliosis: systematic review with best evidence synthesis. N Am Spine Soc J. 2022 Jun 25;11:100140. doi: 10.1016/j.xnsj.2022.100140. eCollection 2022 Sep.

  PMID: 35814492 RESULT

• Alaca N, Cagri Aslan D, Alaca I, Yuksel M. The psychometric properties of the Turkish version of the pectus carinatum body image quality of life questionnaire. Pediatr Surg Int. 2022 Jun;38(6):833-842. doi: 10.1007/s00383-022-05119-w. Epub 2022 Apr 7.

  PMID: 35389073 RESULT

MeSH Terms

Conditions

Funnel Chest; Pectus Carinatum; Scoliosis; Kyphosis; Lordosis

Interventions

Respiratory Function Tests

Condition Hierarchy (Ancestors)

Bone Diseases, Developmental; Bone Diseases; Musculoskeletal Diseases; Musculoskeletal Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cartilage Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Spinal Curvatures; Spinal Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Respiratory System; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Meryem Guneser Gulec, MD

  Gaziosmanpasa Training and Research Hospital Physical Rehabilitation Department

  STUDY CHAIR

• Ebru Yilmaz Yalcinkaya, Prof

  Gaziosmanpasa Training and Research Hospital Physical Rehabilitation Department

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 11, 2023
• First Posted: August 24, 2023
• Study Start: March 9, 2023
• Primary Completion: April 9, 2023
• Study Completion: April 28, 2023
• Last Updated: August 24, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)